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Deep Eutectic Solvent Formulations and Alginate-Based Hydrogels as a New Partne...
Pedro, Sónia N.; Mendes, Maria S. M.; Neves, Bruno M.; Almeida, Isabel Filipa; Costa, Paulo; Correia-Sá, Inês; Vilela, Carla; Freire, Mara G.The transdermal administration of nonsteroidal anti-inflammatory drugs (NSAIDs) is a valuable and safer alternative to their oral intake. However, most of these drugs display low water solubility, which makes their incorporation into hydrophilic biopolymeric drug-delivery systems difficult. To overcome this drawback, aqueous solutions of bio-based deep eutectic solvents (DES) were investigated to enhance the so...
Pullulan microneedle patches for the efficient transdermal administration of in...
Fonseca, Daniela F. S.; Costa, Paulo C.; Almeida, Isabel F.; Dias-Pereira, Patrícia; Correia-Sá, Inês; Bastos, Verónica; Oliveira, HelenaThe present study reports the fabrication of dissolvable microneedle (MN) patches using pullulan (PL), a water-soluble polysaccharide with excellent film-forming ability, for the transdermal administration of insulin, envisioning the non-invasive treatment of diabetes. PL MNs patches were successfully prepared by micromoulding and revealed good thermal stability (Tdmax = 294 °C) and mechanical properties (>0.15...
Anti-inflammatory and antioxidant nanostructured cellulose membranes loaded wit...
Morais, Eduarda S.; Silva, Nuno H. C. S.; Sintra, Tânia E.; Santos, Sónia A. O.; Neves, Bruno Miguel; Almeida, Isabel F.; Costa, Paulo C.The utilization of natural compounds, such as phenolic acids and biopolymers, in the healthcare domain is gaining increasing attention. In this study, bacterial nanocellulose (BC) membranes were loaded with ionic liquids (ILs) based on phenolic acids. These ionic compounds, with improved solubility and bioavailability, were prepared by combining the cholinium cation with anions derived from caffeic, ellagic and...
Secondary Rhinoplasty Using the Technique of Turkish Delight: a Case Report and...
Correia-Sá, Inês; Amarante, José; Horta, Ricardo; Neto, Tiago; Silva, Álvaro; Marques, MarisaRhinoplasty is a demanding task, especially when augmentation of the nasal contour is required. Autologous cartilage grafts are challenging. Contour and alignment of the graft are difficult goals. It is presented a case of a successfully nasal dorsum augmentation in a secondary rhinoplasty with the Turkish Delight technique and a brief review of literature. A 33-years-old female, with history of complete unilat...