4 documents found, page 1 of 1
A Hydrophilic Sulfated Resveratrol Derivative for Topical Application: Sensitiz...
Jesus, Ana; Sebastião, Ana I.; Brites, Gonçalo; Correia-da-Silva, Marta; Cidade, Honorina; Cruz, Maria T.; Sousa, Emília; Almeida, Isabel F.Resveratrol (RSV), a naturally occurring metabolite, is widely used in skincare products, but its hydrophobicity impairs its own incorporation into cosmetic formulations. RSV-GS is a synthetic hydrophilic sulfated glycosylated derivative inspired by marine natural products that present a lower cytotoxicity than RSV while exhibiting similar levels of bioactivity. Herein, we predict the skin sensitization potenti...
Biofouling inhibition with grafted econea biocide: toward a nonreleasing eco-fr...
Regina Ferreira, Olga; Rijo, Patrícia; Gomes, João; Santos, Ricardo; Monteiro, Silvia; Vilas-Boas, Cátia; Correia-da-Silva, Marta; Almada, StephanieThe most effective strategies to control biofouling release toxic and persistent agents into the aquatic environment causing environmental concerns and leading to the implementation of more strict international legislation. This work presents recent progress on an innovative eco-friendly antifouling approach based on the isocyanate-functionalized Econea biocide allowing its chemical fixation in polymeric framew...
Discovery of a New Xanthone against Glioma: Synthesis and Development of (Pro)l...
Alves, Ana; Correia-da-Silva, Marta; Nunes, Claúdia; Campos, João; Sousa, Emília; Silva, Patrícia; Bousbaa, Hassan; Rodrigues, FranciscaFollowing our previous work on the antitumor activity of acetylated flavonosides, a new acetylated xanthonoside, 3,6-bis(2,3,4,6-tetra-O-acetyl-β-glucopyranosyl)xanthone (2), was synthesized and discovered as a potent inhibitor of tumor cell growth. The synthesis involved the glycosylation of 3,6-di-hydroxyxanthone (1) with acetobromo-α-d-glucose. Glycosylation with silver carbonate decreased the amount of gluc...
Sulfated small molecules targeting EBV in Burkitt lymphoma: from in silico scre...
Lima, Raquel T.; Seca, Hugo; Palmeira, Andreia; Fernandes, Miguel X.; Castro, Felipe; Correia-da-Silva, Marta; Nascimento, Maria S. J.; Sousa, EmíliaEpstein–Barr virus (EBV) infects more than 90% of the world population. Following primary infection, Epstein– Barr virus persists in an asymptomatic latent state. Occasionally, it may switch to lytic infection. Latent EBV infection has been associated with several diseases, such as Burkitt lymphoma (BL). To date, there are no available drugs to target latent EBV, and the existing broad-spec trum antiviral drugs...