120 documents found, page 1 of 12
In vitro bone tissue engineering strategies: the relevance of cells and culturi...
Bastos, Ana Raquel Fernandes; Maia, F. Raquel; Oliveira, Joaquim M.; Reis, R. L.; Correlo, V. M.The most recent advances in bone tissue engineering (BTE) approaches step forward in the field of three-dimensional (3D) tissue models, enabling the development of more realistic tools to study bone disorders, such as osteoporosis. BTE field aims to mimic native bone tissue more truthfully, providing an appropriate environment for tissue regeneration and repair through the combination of 3D porous scaffolds, sp...
Enhanced cell uptake of Rhodamine B for photodynamic therapy under hypoxic cond...
Caldas, M.; Artiga, Á.; Marin, R.; Ming, L.; Jaque, D.; da Silva, Lucília Pereira; Reis, R. L.; Correlo, V. M.Photodynamic therapy (PDT) is a promising light-triggered therapy for medical conditions, including solid tumors, and it is already being used in clinical settings. PDT relies on the use of a photosensitizer that generates cytotoxic oxygen species upon photoexcitation. Because of their high molar extinction coefficient, Rhodamine (Rh) dyes are promising candidates as photosensitizers. However, the low solubilit...
Recent advances in nanomaterial-based optical biosensors for food safety applic...
Meira, Diana I.; Barbosa, Ana Isabel Ferreira; Borges, Joel; Reis, R. L.; Correlo, V. M.; Vaz, FilipeGlobal population growth tremendously impacts the global food industry, endangering food safety and quality. Mycotoxins, particularly Ochratoxin-A (OTA), emerge as a food chain production threat, since it is produced by fungus that contaminates different food species and products. Beyond this, OTA exhibits a possible human toxicological risk that can lead to carcinogenic and neurological diseases. A selective, ...
Inconsistency in shoulder arthrometers for measuring glenohumeral joint laxity:...
Gomes, Eluana; Andrade, Renato; Valente, Cristina; Santos, J. Victor; Nunes, Jóni; Carvalho, Óscar Samuel Novais; Correlo, V. M.; Silva, Filipe S.There is no consensus on how to measure shoulder joint laxity and results reported in the literature are not well systematized for the available shoulder arthrometer devices. This systematic review aims to summarize the results of currently available shoulder arthrometers for measuring glenohumeral laxity in individuals with healthy or injured shoulders. Searches were conducted on the PubMed, EMBASE, and Web of...
Preclinical research studies for treating severe muscular injuries: focus on ti...
Alheib, Omar; da Silva, Lucília Pereira; Reis, R. L.; Correlo, V. M.; Kwon, Il KeunSevere skeletal muscle injuries are a lifelong trauma with limited medical solutions. Significant progress has been made in developing in vitro surrogates for treating such trauma. However, more attention is needed when translating these approaches to the clinic. In this review, we survey the potential of tissueengineered surrogates in promoting muscle healing, by critically analyzing data from recent prec...
Collagen membrane from bovine pericardium for treatment of long bone defect
Yamanaka, J. S.; Oliveira, A. C.; Bastos, Ana Raquel Fernandes; Fernandes, Emanuel Mouta; Reis, R. L.; Correlo, V. M.; Shimano, A. C.The treatment of bone regeneration failures has been constantly improved with the study of new biomaterials. Techgraft® is a collagen membrane derived from bovine pericardium, which has been shown to have biocompatibility and effectiveness in tissue repair. However, its use in orthopedics has not yet been evaluated. Therefore, the purpose of this study was to characterize a bovine pericardium collagen membrane ...
Human adipose-derived mesenchymal stem cells laden in gellan gum spongy-like hy...
Alheib, Omar; da Silva, Lucília Pereira; da Silva Morais, Alain; Mesquita, Katia Almeida; Pirraco, Rogério P.; Reis, R. L.; Correlo, V. M.Background: volumetric muscle loss (VML) is a traumatic massive loss of muscular tissue which frequently leads to amputation, limb loss, or lifetime disability. The current medical intervention is limited to autologous tissue transfer, which usually leads to non-functional tissue recovery. Tissue engineering holds a huge promise for functional recovery. Methods: in this work, we evaluated the potential of h...
Pharmacological and non-pharmacological agents versus bovine colostrum suppleme...
Kydonaki, Eirini K.; Freitas, Laura; Reguengo, Henrique; Simón, Carlos Raposo; Bastos, Ana Raquel Fernandes; Fernandes, Emanuel MoutaOsteoporosis is defined by loss of bone mass and deteriorated bone microarchitecture. The present study compared the effects of available pharmacological and non-pharmacological agents for osteoporosis [alendronate (ALE) and concomitant supplementation of vitamin D (VD) and calcium (Ca)] with the effects of bovine colostrum (BC) supplementation in ovariectomized (OVX) and orchidectomized (ORX) rats. Seven-month...
Chitosan micro-membranes with integrated gold nanoparticles as an LSPR-based se...
Meira, Diana Isabela Faria; Proença, Maria Manuela Carvalho; Rebelo, Rita Daniela Nogueira; Barbosa, Ana Isabel Ferreira; Rodrigues, Marco S.Currently, there is an increasing need to develop highly sensitive plasmonic sensors able to provide good biocompatibility, flexibility, and optical stability to detect low levels of analytes in biological media. In this study, gold nanoparticles (Au NPs) were dispersed into chitosan membranes by spin coating. It has been demonstrated that these membranes are particularly stable and can be successfully employed...
Forecast cancer: the importance of biomimetic 3D in vitro models in cancer drug...
Caballero, David; Kundu, B.; Abreu, Catarina M.; Amorim, S.; Fernandes, D. C.; Pires, R. A.; Oliveira, Joaquim M.; Correlo, V. M.; Reis, R. L.Nowadays, the pharmaceutical industry faces a significant challenge related to the high attrition rates of drugs, which is particularly astonishing in oncology [1]. Indeed, several studies have reported that about 95% of anti-cancer drugs tested in phase I fail to reach the market. The reasons for this decline may be very complex, but most likely, they are related to how potential drug candidates are tested, wh...