126 documents found, page 1 of 13
Silane grafted biosourced melanin: A sustainable approach for nanobiosensing ap...
Caldas, Mariana; Neves, Miguel; Franco, Albina R.; Battacharya, Mrinal; Reis, R. L.; Correlo, V. M.Nanotechnology has revolutionized areas of biotechnology owing to its multidiversified applications, improved sensitivity, surface size, and cost. In the past years, some issues have arisen regarding the impact of nanomaterials on the environment and human health. In this regard, there is a growing interest in identifying natural and sustainable nanostructured biomaterials as an alternative to toxic petrochemic...
Natural melanin nanoparticles (MNPs) extracted from Sepia officinalis: A cost-e...
Caldas, Mariana Elisabete Rodrigues; Barbosa, Ana Isabel Ferreira; Bhattacharya, Mrinal; Reis, R. L.; Correlo, V. M.Osteosarcoma conventional chemotherapeutics are known for their side effects, limited options, and induction of drug resistance. This creates the need to develop new therapeutics capable of effectively destroying cancer cells with low toxicity, improving patient survival rate and their life quality. This work reports a novel drug delivery nanoplataform made of Natural Melanin Nanoparticles (MNPs), obtained from...
Human adipose-derived mesenchymal stem cells laden in gellan gum spongy-like hy...
Alheib, Omar; da Silva, Lucília Pereira; da Silva Morais, Alain; Mesquita, Katia Almeida; Pirraco, Rogério P.; Reis, R. L.; Correlo, V. M.Background: volumetric muscle loss (VML) is a traumatic massive loss of muscular tissue which frequently leads to amputation, limb loss, or lifetime disability. The current medical intervention is limited to autologous tissue transfer, which usually leads to non-functional tissue recovery. Tissue engineering holds a huge promise for functional recovery. Methods: in this work, we evaluated the potential of h...
Recent advances in nanomaterial-based optical biosensors for food safety applic...
Meira, Diana I.; Barbosa, Ana Isabel Ferreira; Borges, Joel; Reis, R. L.; Correlo, V. M.; Vaz, FilipeGlobal population growth tremendously impacts the global food industry, endangering food safety and quality. Mycotoxins, particularly Ochratoxin-A (OTA), emerge as a food chain production threat, since it is produced by fungus that contaminates different food species and products. Beyond this, OTA exhibits a possible human toxicological risk that can lead to carcinogenic and neurological diseases. A selective, ...
Inconsistency in shoulder arthrometers for measuring glenohumeral joint laxity:...
Gomes, Eluana; Andrade, Renato; Valente, Cristina; Santos, J. Victor; Nunes, Jóni; Carvalho, Óscar Samuel Novais; Correlo, V. M.; Silva, Filipe S.There is no consensus on how to measure shoulder joint laxity and results reported in the literature are not well systematized for the available shoulder arthrometer devices. This systematic review aims to summarize the results of currently available shoulder arthrometers for measuring glenohumeral laxity in individuals with healthy or injured shoulders. Searches were conducted on the PubMed, EMBASE, and Web of...
Preclinical research studies for treating severe muscular injuries: focus on ti...
Alheib, Omar; da Silva, Lucília Pereira; Reis, R. L.; Correlo, V. M.; Kwon, Il KeunSevere skeletal muscle injuries are a lifelong trauma with limited medical solutions. Significant progress has been made in developing in vitro surrogates for treating such trauma. However, more attention is needed when translating these approaches to the clinic. In this review, we survey the potential of tissueengineered surrogates in promoting muscle healing, by critically analyzing data from recent prec...
Collagen membrane from bovine pericardium for treatment of long bone defect
Yamanaka, J. S.; Oliveira, A. C.; Bastos, Ana Raquel Fernandes; Fernandes, Emanuel Mouta; Reis, R. L.; Correlo, V. M.; Shimano, A. C.First published: 17 August 2022; The treatment of bone regeneration failures has been constantly improved with the study of new biomaterials. Techgraft® is a collagen membrane derived from bovine pericardium, which has been shown to have biocompatibility and effectiveness in tissue repair. However, its use in orthopedics has not yet been evaluated. Therefore, the purpose of this study was to characterize a bovi...
In vitro cancer models: a closer look at limitations on translation
Antunes, Nina; Kundu, Banani; Kundu, Subhas C; Reis, R. L.; Correlo, V. M.In vitro cancer models are envisioned as high-throughput screening platforms for potential new therapeutic discovery and/or validation. They also serve as tools to achieve personalized treatment strategies or real-time monitoring of disease propagation, providing effective treatments to patients. To battle the fatality of metastatic cancers, the development and commercialization of predictive and robust preclin...
3D bioprinting of gellan gum-based hydrogels tethered with laminin-derived pept...
Alheib, Omar; da Silva, Lucília P.; Youn, Yun Hee; Kwon, Il Keun; Reis, R. L.; Correlo, V. M.The treatment of skeletal muscle defects is still a topic of noteworthy concern since surgical intervention is not capable of recovering muscle function. Herein, we propose myoblasts laden in laminin-inspired biofunctionalized gellan gum hydrogels as promising tissue-engineered skeletal muscle surrogates. Gellan gum-based hydrogels were developed by combining native gellan gum (GG) and GG tethered with laminin-...
In vitro cancer models: a closer look at limitations on translation
Antunes, Nina; Kundu, Banani; Kundu, Subhas C; Reis, R. L.; Correlo, V. M.In vitro cancer models are envisioned as high-throughput screening platforms for potential new therapeutic discovery and/or validation. They also serve as tools to achieve personalized treatment strategies or real-time monitoring of disease propagation, providing effective treatments to patients. To battle the fatality of metastatic cancers, the development and commercialization of predictive and robust preclin...