6 documents found, page 1 of 1
SCCS Opinion on Biphenyl-2-ol and Sodium 2-biphenylolate used in cosmetic produ...
Bernauer, Ulrike; Bodin, Laurent; Chaudhry, Qasim; Coenraads, Pieter Jan; Ezendam, Janine; Gaffet, Eric; Galli, Corrado L.; Panteri, EiriniHighlights: -o-Phenylphenol (OPP) is safe when used as preservative up to a maximum concentration of 0.2 % in rinse-off cosmetic products; - o-Phenylphenol (OPP) is safe when used as preservative up to a maximum concentration of 0.15 % in leave-on cosmetic products; - Sodium o-Phenylphenate is safe when used as preservative up to a maximum concentration of 0.2 % in rinse-off cosmetic products; - Sodium o-Phenyl...
Follow‐up of the re‐evaluation of silver (E 174) as a food additive (EFSA‐Q‐202...
EFSA Panel on Food Additives and Flavourings (FAF); Andreassen, Monica; Aquilina, Gabriele; Bastos, Maria Lourdes; Boon, Polly; Castle, LaurenceSilver (E 174) is a food colour that was re‐evaluated by the EFSA ANS Panel (2016). The ANS Panel concluded that the information available then, was insufficient to assess the safety of silver as food additive. The major issues included limited characterisation of silver E 174 (e.g. quantity of nanoparticles) and release of ionic silver. Following a European Commission call for further data to fill the data gap...
Scientific Opinion on benzophenone – 4 (CAS No. 4065-45-6, EC No. 223-772-2) us...
Van Haecke, Tamara; Rogiers, Vera; Scientific Committee on Consumer Safety - SCCS; Bernauer, Ulrike; Bodin, Laurent; Chaudhry, QasimHighlights: -BZP-4 is safe when used as UV filter up to a max. conc. of 5 % in sunscreen, all leave-on products (tot. dermal aggregate); -BZP-4 is safe when used as UV filter up to a max. conc. of 5 % in sunscreen, all rinse-off products (tot. dermal aggregate); -Same for lipstick, sunscreen propellant and pump spray (separately or in combination based on determ. aggregated exposure); -BZP-4 use as stabiliser w...
A critical review to identify data gaps and improve risk assessment of bispheno...
Mhaouty-Kodja, Sakina; Zalko, Daniel; Tait, Sabrina; Testai, Emanuela; Viguié, Catherine; Corsini, Emanuela; Grova, Nathalie; Buratti, Franca MariaBisphenol A (BPA), a synthetic chemical widely used in the production of polycarbonate plastic and epoxy resins, has been associated with a variety of adverse effects in humans including metabolic, immunological, reproductive, and neurodevelopmental effects, raising concern about its health impact. In the EU, it has been classified as toxic to reproduction and as an endocrine disruptor and was thus included in ...
New approach methodologies to enhance human health risk assessment of immunotox...
Snapkow, Igor; Smith, Nicola M.; Arnesdotter, Emma; Beekmann, Karsten; Blanc, Etienne B.; Braeuning, Albert; Corsini, Emanuela; Sollner Dolenc, MarijaAs a complex system governing and interconnecting numerous functions within the human body, the immune system is unsurprisingly susceptible to the impact of toxic chemicals. Toxicants can influence the immune system through a multitude of mechanisms, resulting in immunosuppression, hypersensitivity, increased risk of autoimmune diseases and cancer development. At present, the regulatory assessment of the immuno...
Hazard assessment of bisphenol A alternatives to close data gaps of concern for...
Aiello Holden, Kiara; Tait, Sabrina; Viguié, Catherine; Mhaouty-Kodja, Sakina; Corsini, Emanuela; Silva, Maria João; Zalko, Daniel; Testai, EmanuelaWHY? With the upcoming restrictions on BPA, BPA alternatives’ tonnages and frequencies of use are expected to severely increase in the coming years. Therefore, this project aims to fill the identified data gaps, providing a complete data set for at least four relevant BPA alternatives identified in an ad hoc Workshop together with ECHA and EFSA. We will fill the knowledge gaps on human health on five toxicologi...