49 documents found, page 1 of 5
Photodynamic inactivation of methicillin-resistant Staphylococcus aureus using ...
Teixeira, Lília; Fraga, Sónia; Simões, Manuel; Borges, AnabelaBackground: Antibiotic-resistant pathogens, such as methicillin-resistant Staphylococcus aureus (MRSA), pose significant challenges in the treatment of chronic wound infections. Antibacterial photodynamic therapy (aPDT) offers a localized, resistance-independent alternative to antibiotics [1]. In aPDT, bacteria are targeted by molecules called photosensitizers (PSs) that are activated by light. Natural PSs are ...
Resolvin E1-Chemerin receptor 1 axis is dysregulated in critical COVID-19 patients
Silva-Pereira, Carolina; Reina-Couto, Marta; Pereira-Terra, Patrícia; Teixeira-Santos, Luísa; Martins, Sandra; Pinho, Dora; Soares, Miguel LuzResolvin E1 (RvE1) and Resolvin D1 (RvD1) are key resolvins implicated in inflammation resolution of respiratory and infectious diseases. In contrast to cytokines, they have been scarcely explored in COVID-19 and their ability for discriminating COVID-19 severity and patient outcomes has not been compared with that of cytokines. Therefore, among a panel comprising cytokines (interleukin (IL)-1beta, IL-6, IL-10,...
Incidental nanoparticle characterisation in industrial settings to support risk...
Moreno-Martín, Veronica; López, Maria; Bou, David; Fraga, Sónia; Teixeira, João Paulo; López-Lilao, Ana; Sanfélix, Vicenta; Monfort, Eliseo; Viana, MarResearch on nanoparticle (NP) release and potential exposure can be assessed through experimental field campaigns, laboratory simulations, and prediction models. However, risk assessment models are typically designed for manufactured NP (MNP) and have not been adapted for incidental NP (INP) properties. A notable research gap is identifying NP sources and their chemical, physical, and toxicological properties, ...
Systematic review on toxicological effects of platinum nanoparticles: towards t...
Touzani, Assia; Ramos-Pan, Lucía; Fraga, Sónia; Fernández-Bertólez, Natalia; Laffon, Blanca; Valdiglesias, VanessaPlatinum nanoparticles (PtNP) have received considerable attention in the nanomedicine field due to their magnetic, catalytic, and optical properties. However, the potential toxicity of PtNP has not been properly evaluated yet, and current information on the possible risks related to their use is still limited. On this basis, the main objective of this systematic review was to gather available data on PtNP biol...
Hazard characterization of the mycotoxins enniatins and beauvericin to identify...
Behr, Anne-Cathrin; Fæste, Christiane Kruse; Azqueta, Amaya; Tavares, Ana M.; Spyropoulou, Anastasia; Solhaug, Anita; Olsen, Ann-KarinEnniatins (ENNs) and beauvericin (BEA) are cyclic hexadepsipeptide fungal metabolites which have demonstrated antibiotic, antimycotic, and insecticidal activities. The substantial toxic potentials of these mycotoxins are associated with their ionophoric molecular properties and relatively high lipophilicities. ENNs occur extensively in grain and grain-derived products and are considered a food safety issue by t...
Impact of gold nanoparticle exposure on genetic material
Ramos-Pan, Lucía; Touzani, Assia; Fernández-Bertólez, Natalia; Fraga, Sónia; Laffon, Blanca; Valdiglesias, VanessaMetal nanoparticles, with gold nanoparticles (AuNP) at the forefront, have gained immense attention due to their unique properties. At the nanoscale, gold exhibits remarkable physical, chemical, optical, and electronic features, making it ideal for a plethora of applications, including bioimaging, sensing, diagnostics, and drug delivery. Despite their promising utility, concerns have arisen regarding the potent...
Biocompatibility evaluation of CeO2 nanoparticles to be employed as nanodrugs i...
Fernández-Bertólez, Natália; Touzani, Assia; Martínez, L.; Reis, Ana Teresa; Fraga, Sónia; Teixeira, João Paulo; Costa, Carla; Pásaro, EduardoCerium dioxide nanoparticles (CeO2NP) have recently gained attention for their unique structure-dependent properties, antioxidant enzyme-like behaviour, ROS scavenging activity and great potential for biomedical applications. In addition to their antioxidant and anti-inflammatory activity, CeO2NP are also known to exhibit anticancer potential, providing an attractive opportunity for use in cancer therapy, as a ...
The Toxicity of Nanomaterials and Legacy Contaminants: Risks to the Environment...
Reis, Ana Teresa; Costa, Carla; Fraga, SóniaNanotechnology and the incorporation of nanomaterials (NM) into everyday products help to solve problems in society and improve the quality of life, allowing for major advances in the technological, industrial, and medical fields. Despite this positive and encouraging side of nanotechnology, the potential risks of NM to human health and the environment, as well as the ethical, legal, and social implications ass...
Assessing the in vitro toxicity of airborne (nano)particles to the human respir...
Bessa, Maria João; Brandão, Fátima; Rosário, Fernanda; Moreira, Luciana; Reis, Ana Teresa; Valdiglesias, Vanessa; Laffon, Blanca; Fraga, SóniaSeveral studies have been conducted to address the potential adverse health risks attributed to exposure to nanoscale materials. While in vivo studies are fundamental for identifying the relation-ship between dose and occurrence of adverse effects, in vitro model systems provide important information regarding the mechanism(s) of action at the molecular level. With a special focus on exposure to inhaled (nano)p...
Comparative Analysis of the Toxicity Profile of Eleven Consumer-Relevant Nanoma...
Pires, Joana; Moreira, Luciana; Teixeira, João Paulo; Fraga, SóniaBackground: The growing number of items incorporating nanomaterials (NM) has prompted considerable concerns about human health and safety [1]. Metal nanoparticles, inorganic non-metallic, and carbon-based NM are among the types with the highest market volume [2]. Objective: The purpose of this study was to determine the effect of chemical composition [Ag, Au, TiO2, SiO2, and graphene oxide (nano_GO)], primary s...