13 documents found, page 1 of 2

Concomitant immunity in persistent Leishmania infections

Concomitant immunity (CI) can be viewed as an example of coevolution between the microorganisms and their long-lived hosts. Such an ecological trade-off may be advantageous to both the microbe and the host, as it allows protozoa and helminths to maintain their genetic features while providing the host, particularly mammals, with long-standing protection against reinfection by the same microbe. In Leishmania inf...

Cutaneous leishmaniasis due to Leishmania (L.) mexicana

N-Myristoyltransferase Inhibition in Parasitic Pathogens

Neglected tropical diseases (NTDs) constitute a group of infectious diseases that severely affect the health of impoverished populations, and the health, economies, and health systems of affected countries. Leishmaniasis and human African trypanosomiasis (HAT) are particularly notable, and malaria, despite not being neglected, is part of the “big three” (HIV, tuberculosis, and malaria) with high incidence, incr...

Surveillance of leishmaniasis cases from 15 European centres, 2014 to 2019

Background: Surveillance of human leishmaniasis in Europe is mostly limited to country-specific information from autochthonous infections in the southern part. As at the end of 2021, no integrated analysis has been performed for cases seen across centres in different European countries. Aim: To provide a broad perspective on autochthonous and imported leishmaniasis cases in endemic and non-endemic countries in ...

Synthesis, structure and antileishmanial evaluation of endoperoxide–pyrazole hy...

Leishmaniases are among the most impacting neglected tropical diseases. In attempts to repurpose antimalarial drugs or candidates, it was found that selected 1,2,4-trioxanes, 1,2,4,5-tetraoxanes, and pyrazole-containing chemotypes demonstrated activity against <i>Leishmania</i> parasites. This study reports the synthesis and structure of trioxolane–pyrazole (<b>OZ1</b>, <b>OZ2</b>) and tetraoxane–pyrazole (<b>T...

1,2,4-Trioxolane and 1,2,4,5-Tetraoxane endoperoxides against old-world Leishma...

Leishmaniasis remains one of the ten Neglected Tropical Diseases with significant morbidity and mortality in humans. Current treatment of visceral leishmaniasis is difficult due to a lack of effective, non-toxic, and non-extensive medications. This study aimed to evaluate the selectivity of 12 synthetic endoperoxides (1,2,4-trioxolanes; 1,2,4,5-tetraoxanes) and uncover their biochemical effects on <i>Leishmania...

Report of in vitro antileishmanial properties of Iberian macroalgae

Here is reported the anti Leishmania infantum activity of 48 hexane, CH2Cl2 and MeOH extracts from 16 macroalgae collected on the Iberian Coast. Seven hexane and CH2Cl2 Cystoseira baccata, Cystoseira barbata, Cystoseira tamariscifolia, Cystoseira usneoides, Dictyota spiralis and Plocamium cartilagineum extracts were active towards promastigotes (IC50 29.8-101.8 mu g/mL) inducing strong morphological alterations...

LEISHMANIOSE: DOENÇA NEGLIGENCIADA DA POBREZA E EMERGENTE NO MARE NOSTRUM – OIT...

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TRIPANOSSOMOSE HUMANA AMERICANA – A DOENÇA DE CHAGAS

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Report of in vitro antileishmanial properties of Iberian macroalgae

Here is reported the anti Leishmania infantum activity of 48 hexane, CH2Cl2 and MeOH extracts from 16 macroalgae collected on the Iberian Coast. Seven hexane and CH2Cl2Cystoseira baccata, Cystoseira barbata, Cystoseira tamariscifolia, Cystoseira usneoides, Dictyota spiralis and Plocamium cartilagineum extracts were active towards promastigotes (IC50 29.8-101.8 μg/mL) inducing strong morphological alterations in...