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Venetoclax: A New Hope for Elderly Patients with Acute Myeloid Leukemia
Marques, Bárbara; Afonso, Carolina; Cortesão, EmíliaAcute myeloid leukemia (AML) is a hematopoietic malignancy characterized by clonal proliferation, with increased incidence with advancing age. AML with myelodysplasia-related changes (AML-MRC) represents an AML subtype with a poor prognosis and challenging treatment, particularly in elderly patients. We report the case of a 77-year-old patient diagnosed with high-risk AML-MRC, ineligible for intensive chemother...
DNA Methylation Is Correlated with Oxidative Stress in Myelodysplastic Syndrome...
Gonçalves, Ana Cristina; Alves, Raquel; Baldeiras, Inês; Marques, Bárbara; Oliveiros, Bárbara; Pereira, Amélia; Costa, José Manuel NascimentoOxidative stress and abnormal DNA methylation have been implicated in cancer, including myelodysplastic syndromes (MDSs). This fact leads us to investigate whether oxidative stress is correlated with localized and global DNA methylations in the peripheral blood of MDS patients. Sixty-six MDS patients and 26 healthy individuals were analyzed. Several oxidative stress and macromolecule damage parameters were anal...
Oxidative Stress Parameters Can Predict the Response to Erythropoiesis-Stimulat...
Gonçalves, Ana Cristina; Alves, Raquel; Baldeiras, Inês; Jorge, Joana; Marques, Bárbara; Paiva, Artur; Oliveiros, Bárbara; Cortesão, EmíliaOxidative stress has been implicated in the development of several types of cancer, including myelodysplastic syndromes (MDS), as well as in the resistance to treatment. In this work, we assessed the potential of oxidative stress parameters to predict the response to erythropoiesis-stimulating agents (ESAs) in lower-risk MDS patients. To this end, we analyzed the systemic levels of reactive species (peroxides a...
Eritropoietina Sérica como Marcador Prognóstico em Síndrome Mielodisplásica
Cortesão, Emília; Tenreiro, Rita; Ramos, Sofia; Pereira, Marta I.; César, Paula; Carda, José P.; Gomes, Marília; Rito, Luís Carlos; Magalhães, EmíliaIntrodução: A síndrome mielodisplásica é uma doença heterogénea caracterizada por displasia, medula hipercelular, citopenias e risco de evolução para leucemia aguda. Outros factores de prognóstico, nomeadamente, fibrose medular, elevação da enzima desidrogenase do lactato e β2-microglobulina têm sido descritos, contudo, a decisão terapêutica baseia-se no score do International Prognostic Scoring System. Materia...
Serum Erythropoietin as Prognostic Marker in Myelodysplastic Syndromes
Cortesão, Emília; Tenreiro, Rita; Ramos, Sofia; Pereira, Marta; César, Paula; Carda, José P.; Gomes, Marília; Rito, Luís; Magalhães, EmíliaIntroduction: This myelodysplastic syndromes are a heterogeneous entity characterized by dysplasia, hypercellular bone marrow, cytopenias and risk of transformation to acute leukaemia. Prognostic factors, such as bone marrow fibrosis, lactate dehydrogenase and β2-microglobulin elevation have been described, but treatment is mainly based in the International Prognostic Scoring System.Material and Methods: Our ai...
Acute monocytic leukaemia presenting as a febrile rash
Marques, Nuno; Deus, Adelaide; Ballesta, Laura; Cortesão, Emília; Almeida, Sérgio; Espadana, Ana Isabel; Aragão, António; Santos, LèlitaCutaneous involvement has been described in all forms of acute myeloid leukaemia as well as in other forms of myeloproliferative disease.We describe a clinical case of a 70 year-old female, whose first manifestation of leukaemia was a 5 day history of diffuse cutaneous rash, fever and muscle pain. Epidemiologically, she was a street vendor and had contact with dogs and cats.On clinical examination she was febri...
Acute myelogenous leukemia presenting as diabetes insipidus.
Calretas, Susana; Leitão, Sara; Cortesão, Emília; Espadana, Ana Isabel; Santos, Rui M; Porto, ArmandoCentral diabetes insipidus, is a syndrome characterized by the excretion of abnormally elevated volumes of diluted urine, due to the diminution of reabsorption of water in the collecting ducts, induced by the diminution of production of antidiuretic hormone. The involvement of the central nervous system in the leukaemia is frequent, but the association leukaemia/diabetes insipidus is rare. We describe a clinica...