4 documents found, page 1 of 1
Global expression of Chagas´ disease - emerging opportunities and impact in Por...
Cortez, J; Ramos, E; Valente, C; Seixas, J; Vieira, AChagas disease, caused by the protozoan Trypanosoma cruzi is endemic in the countries of Central and South America. Despite vector control programs and other measures taken in the blood banks and maternity hospitals, it is estimated that there are about eight million people infected worldwide. Although traditionally associated with rural life and poverty, the current migration flows transform it into a global p...
Emerging and under-recognized Chagas cardiomyopathy in non-endemic countries
Cortez, J; Providência, R; Ramos, E; Valente, C; Seixas, J; Meruje, M; Leitão-Marques, A; Vieira, ADue to recent population emigration movements, an epidemic of Chagas disease is currently menacing most developed countries. The authors report the case of a 53-year-old Brazilian woman living in Europe for the last 10 years who developed heart failure symptoms, having a previous symptomatic sinus node disease with a pacemaker implant at age of 40 years. The diagnosis was based on serology and myocardial biopsy...
Bionanoconjugates of tyrosinase and peptide-derivatised gold nanoparticles for ...
Cortez, J; Vorobieva, E; Gralheira, D; Osorio, I; Soares, L; Vale, N; Pereira, E; Gomes, P; Franco, RBionanoconjugates of the enzyme tyrosinase (TYR) and gold nanoparticles (AuNPs) functionalised with a peptide (CALNN) were produced in solution and characterised. The formation of stable TYR-AuNP:CALNN bionanoconjugates (BNCs) was supported by a decrease of the surface charge of the BNCs as determined by zeta-potential and an increase in hydrodynamic diameter as determined by Dynamic Light Scattering (DLS). UV/...
Atherosclerosis. Old problem, new perspectives.
Cortez, JAtherosclerosis is the major cause of mortality in the population of the, so called, developed countries of western culture. Since the first half of this century, hypercholesterolemia was the hallmark for the investigation of atherosclerosis, improving the level of knowledge about the complex metabolism of lipoproteins. The occurrence of atherosclerosis in normolipidaemic subjects, and the relationship between ...