9 documents found, page 1 of 1
Enhancing Cancer Vaccine Efficacy
Gibadullin, Ruslan; Suárez, Óscar; Lazaris, Foivos S.; Gutiez, Naiara; Atondo, Estibaliz; Araujo-Aris, Sarai; Eguskiza, Ander; Niu, JianiFunding Information: This project has received partial funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No. 956544. This work was also supported in part by the National Institutes of Health grant (R01 GM056414 and its successor R35 GM151985) awarded to S.H.G. We thank the Agencia Estatal de Investigación (AEI, PID2021-127622OB-I00 ...
Decoding the Molecular Basis of the Specificity of an Anti-sTn Antibody
Soares, Cátia O.; Laugieri, Maria Elena; Grosso, Ana Sofia; Natale, Mariangela; Coelho, Helena; Behren, Sandra; Yu, Jin; Cai, Hui; Franconetti, AntonioFunding Information: This work is funded by the European Union under Horizon Europe (project 101079417 \u2500 GLYCOTwinning).The authors also thank Agencia Estatal de Investigacio\u0301n of Spain (PID2021-127662OB-I00 to F.C. and PID2019-107770RA-I00 to J.E.-O), the Juan de la Cierva Formacio\u0301n 2021 (FJC2021-046465-I to M.E.L). J.J.-B, J.E.-O, and M.E.L. also thank the Severo Ochoa Center of Excellence Acc...
Structure-Guided Approach for the Development of MUC1-Glycopeptide-Based Cancer...
Bermejo, Iris A.; Guerreiro, Ana; Eguskiza, Ander; Martínez-Sáez, Nuria; Lazaris, Foivos S.; Asín, Alicia; Somovilla, Víctor J.; Compañón, IsmaelF.C. thanks the Mizutani Foundation for Glycoscience (grant 220115). I.A.B. and A.A. thank the Asociación Española Contra el Cancer (AECC), sección La Rioja, for doctoral fellowship. We thank the ALBA (Barcelona, Spain) synchrotron beamline XALOC. We thank ARAID, the Agencia Estatal de Investigación (AEI, BFU2016-75633-P and PID2019-105451GB-I00 to R.H.-G., PID2021-127622OB-I00 and PDC2022-133725-C21 to F.C., P...
Structural basis for the synthesis of the core 1 structure by C1GalT1
González-Ramírez, Andrés Manuel; Grosso, Ana Sofia; Yang, Zhang; Compañón, Ismael; Coelho, Helena; Narimatsu, Yoshiki; Clausen, Henrik; Marcelo, FilipaLA/P/0140/2020 MX20229-11 BFU2016-75633-P PID2019-105451GB-I00 RTI2018-099592-B-C21 E34_R17 LMP58_18 DNRF107 LA/P/0140/2020 2020.00233.CEECIND 2020.03261.CEECIND ROTEIRO/0031/2013–PINFRA/22161/2016 N°283570 BIOSTRUCTX_5186). Publisher Copyright: © 2022, The Author(s).; C1GalT1 is an essential inverting glycosyltransferase responsible for synthesizing the core 1 structure, a common precursor for mucin-type O-gly...
Atomic and Specificity Details of Mucin 1 O-Glycosylation Process by Multiple P...
Coelho, Helena; Rivas, Matilde De Las; Grosso, Ana S.; Diniz, Ana; Soares, Cátia O.; Francisco, Rodrigo A.; Dias, Jorge S.; Compañon, IsmaelIF/00780/2015 PTDC/BIA-MIB/31028/2017 UIDP/04378/2020 UIDB/04378/2020 LA/P/0140/2020 SFRH/BD/140394/2018 PD/BD/142847/2018 PD00065/2013 DL 57/2016 ROTEIRO/0031/2013-PINFRA/22161/2016 BFU2016-75633-P PID2019-105451GB-I00 E34_R17 LMP58_18 to R.H-G RTI2018-099592-B-C21 ITN, GA-642157 COST Action GLYCONanoProbes (CA18132) ERC-2017-AdG, project number 788143-RECGLYCANMR RTI218-094751-B-C21) DNRF107; The large family...
Crystal Structure of the Carbohydrate Recognition Domain of the Human Macrophag...
Gabba, Adele; Bogucka, Agnieszka; Luz, John G.; Diniz, Ana; Coelho, Helena; Corzana, Francisco; Cañada, Francisco Javier; Marcelo, Filipa12/IA/1398 16/IA/4419 GOIPG/2016/858 IF/00780/2015 PTDC/BIA-MIB/31028/2017 UIDB/04378/2020 PD/BD/142847/2018 RTI2018-094751-B-C22 RTI2018-099592-B-C2.; The human macrophage galactose lectin (MGL) is an endocytic type II transmembrane receptor expressed on immature monocyte-derived dendritic cells and activated macrophages and plays a role in modulating the immune system in response to infections and cancer. MGL...
Allosteric Antagonist Modulation of TRPV2 by Piperlongumine Impairs Glioblastom...
Conde, João; Pumroy, Ruth A.; Baker, Charlotte; Rodrigues, Tiago; Guerreiro, Ana; Sousa, Bárbara B.; Marques, Marta C.; De Almeida, Bernardo P.Funding: We thank Sabine Baxter for assistance with hybridoma and cell culture at the University of Pennsylvania Perelman School of Medicine Cell Center Services Facility. We acknowledge the use of cryo-EM instruments at Pfizer Inc. The cryo-EM work was supported by a grant from the National Institute of Health (R01GM103899 and R01GM129357 to V.Y.M.-B.). The TRPV2-flag-RFP construct cloned into the pEGFP-N2 vec...
Structural and Mechanistic Insights into the Catalytic-Domain-Mediated Short-Ra...
De Las Rivas, Matilde; Paul Daniel, Earnest James; Coelho, Helena; Lira-Navarrete, Erandi; Raich, Lluis; Compañón, Ismael; Diniz, Ana; Lagartera, Laurainfo:eu-repo/grantAgreement/FCT/5876/147258/PT We thank synchrotron radiation sources DLS (Oxford) and in particular beamline I03 (experiment number MX10121-15). We thank ARAID, MEC (CTQ2013-44367-C2-2-P, BFU2016-75633-P, CTQ2015-67727-R, CTQ2015-70524-R, and CTQ2017-85496-P), AGAUR (SGR2017-1189), the National Institutes of Health (R01-GM113534, and instrument Grant GM113534-01S to T. A. Gerken), the Danish Na...
The interdomain flexible linker of the polypeptide GalNAc transferases dictates...
De Las Rivas, Matilde; Lira-Navarrete, Erandi; Daniel, Earnest James Paul; Companõn, Ismael; Coelho, Helena; Diniz, Ana; Jiménez-Barbero, JesúsWe thank synchrotron radiation sources DLS (Oxford) and in particular beamline I03 (experiment number MX10121-7). We thank ARAID, MEC (CTQ2013-44367-C2-2-P, BFU2016-75633-P, CTQ2015-67727-R, CTQ2015-70524-R, and RYC-2013-14706), the National Institutes of Health (GM113534, and instrument grant GM113534-01S), the Danish National Research Foundation (DNRF107), the FCT-Portugal (UID/Multi/04378/2013 and PTNMR Proj...