3 documents found, page 1 of 1
PD-1 and ICOS are coexpressed in T follicular helper cells but define three sta...
Ribeiro, Filipa; Antunes, Diogo; Pires, Ana R.; Rino, José; Filipe, Beatriz; Jesus, Kátia; Correia, Ricardo; Fonseca, Válter R; Kumar, SaumyaHumoral responses to infection or vaccination require T cell-B cell interactions. T follicular helper (TFH) cells drive germinal center (GC) responses by providing help to B cells, whereas T follicular regulatory (TFR) cells regulate them. Both mature GC-located TFH and TFR cells are widely characterized by the expression of ICOS and PD-1. However, although human TFR cells share many phenotypic characteristics ...
Unveiling the regulation of germinal centre responses and antibody production b...
Kumar, SaumyaGerminal Centres (GCs) are the sites in secondary lymphoid tissues specialized in the selection of the effective antibody response against invading pathogens. Within GCs, B cells undergo class switch recombination (CSR) and somatic hyper-mutation (SHM) followed by the selection of high-affinity clones in a T-cell-dependent manner. The GC T cells specialized in providing help to B cells, called T follicular help...
Molecular markers distinguishing T Cell subtypes with TSDR strand-bias methylation
Minskaia, Ekaterina; Saraiva, Bárbara C.; Soares, Maria Vieira; Azevedo, Rita I.; Ribeiro, Ruy M.; Kumar, Saumya; Vieira, Ana I. S.; Lacerda, JoãoHuman regulatory CD4+CD25+FOXP3+ T cells (Treg) play important roles in the maintenance of self-tolerance and immune homeostasis in various disease settings and are also involved in the suppression of effective immune responses. These cells are heterogeneous in phenotype and function, and the ability to reliably distinguish between various FOXP3-expressing subpopulations can affect the development of successful...