Funding Information: The authors would like to acknowledge clinicians from the Breast and Neuropsychiatry Units of the Champalimaud Clinical Centre (Champalimaud Foundation), for assistance in patient recruitment and assessment, and the BOUNCE and FAITH Consortium members for their contributions to this study. Funding Information: RL is supported by the 2018 Scientific Employment Stimulus from Fundação para a C...
Publisher Copyright: © 2023, The Author(s).; The success of personalized medicine depends on the discovery of biomarkers that allow oncologists to identify patients that will benefit from a particular targeted drug. Molecular tests are mostly performed using tumor samples, which may not be representative of the tumor’s temporal and spatial heterogeneity. Liquid biopsies, and particularly the analysis of circula...
Funding: RL was supported by the 2018 Scientific Employment Stimulus from Fundação para a Ciência e Tecnologia, Portugal (CEECIND/04157/2018). DF, BS, and AO-M were supported by the BOUNCE project (grant agreement no. 777167), and AO-M was supported by the FAITH project (grant agreement no. 875358), both funded by the European Union’s Horizon 2020 Research and Innovation Programme.; Background: The impact of a ...
UIDP/04378/2020 UIDB/04378/2020 LA/P/0140/2020; Chronic Myeloid Leukemia (CML) is a rare malignant proliferative disease of the hematopoietic system, whose molecular hallmark is the Philadelphia chromosome (Ph). The Ph chromosome originates an aberrant fusion gene with abnormal kinase activity, leading to the buildup of reactive oxygen species and genetic instability of relevance in disease progression. Several...