38 documents found, page 1 of 4
Bidirectional flow of action potentials in axons drives activity dynamics in ne...
Mateus, J. C.; Lopes, C. D. F.; Aroso, M.; Costa, A. R.; Gerós, A.; Meneses, J.; Faria, P.; Neto, E.; Lamghari, M.; Sousa, M. M.; Aguiar, PObjective. Recent technological advances are revealing the complex physiology of the axon and challenging long-standing assumptions. Namely, while most action potential (AP) initiation occurs at the axon initial segment in central nervous system neurons, initiation in distal parts of the axon has been reported to occur in both physiological and pathological conditions. The functional role of these ectopic APs, ...
Low-cost videos for learning mathematics by teaching
Caldeira, A. P.; Lopes, S. O.; Figueiredo, I. P.; Costa, A. R.Technology plays an important role in everyday life and can be used in education. Video is a source of material that can play an important role in the teaching and learning field. Using videos engages students, aids student retention of knowledge, motivates interest in the subject matter, and illustrates the relevance of many concepts. In this chapter, the authors describe two teaching experiences involving vid...
The effects of motivation in student academic success
Caldeira, A.; Lopes, S. O.; Costa, A. R.; Figueiredo, I.It is common sense, that the student́s motivation is a key element within the learning process, and technology is an important tool to motivate students for learning. The modern world is becoming a place where a huge variety of technologies emerges, for example, smartphones, computers, videos... The use of technology, in the learning process, is a breath of fresh air inside and outside the classroom Videos is a...
Ciganos portugueses: escola e mudança social
Mendes, M. M.; Magano, O.; Costa, A. R.O cumprimento da escolaridade obrigatória, o sucesso e o controlo do abandono escolar estão longe de ser metas atingidas em Portugal para as crianças e jovens ciganos. Atualmente está mais clara a importância da escolarização, seja do ponto de vista do estado, regulador do acesso de todos ao sistema de ensino público, seja por parte das famílias, que reconhecem a sua importância como recurso essencial para uma ...
Gender differences in first-year College students’ academic expectations
Diniz, A. M.; Alfonso, S.; Araújo, A. M.; Deaño, M.; Costa, A. R.; Conde, Á; Almeida, L. S.Based on a multidimensional definition of academic expectations (AEs), the authors examine students’ AE component scores across countries and genders. Two samples (343 Portuguese and 358 Spanish students) completed the Academic Perceptions Questionnaire (APQ) six months after enrolling in their universities. Factorial invariance was ensured across countries and genders, allowing us to study AEs using the APQ fo...
Os ciganos de Lisboa e a escolarização: evoluções, impasses, dilemas (2003-2015)
Lopes, D. S.; Costa, A. R.O presente artigo debruça-se sobre a relação dos ciganos com a escola, tomando como exemplo a população residente num bairro de Lisboa em dois momentos distintos, cada um deles correspondendo à realização de um trabalho de campo: 2003-2005 e 2014-2015. A informação empírica decorrente destas investigações permite afirmar que os ciganos de Lisboa valorizam uma certa aproximação e integração no mundo não-cigano q...
3-Hydroxypyrrolidine and (3,4)-dihydroxypyrrolidine derivatives: inhibition of ...
Carreiro, E. P.; Louro, P.; Adriano, G; Guedes, R. A.; Vannuchic, N.; Costa, A. R.; Antunes, C. M.; Guedes, R. C.; Burke, A.J.Thirteen pyrrolidine-based iminosugar derivatives have been synthesized and evaluated for inhibition of α-glucosidase from rat intestine. The compounds studied were the non-hydroxy, mono-hydroxy and dihydroxypyrrolidines. All the compounds were N-benzylated apart from one. Four of the compounds had a carbonyl group in the 2,5-position of the pyrrolidine ring. The most promising iminosugar was the trans-3,4-dihy...
Body image perception in people with type 2 diabetes: does perceived image matc...
Pereira, A. R.; Costa, A. R.; Guerreiro, Catarina Sousa; Carolino, ElisabeteRationale: Body image misperception and body image dissatisfaction can lead to underestimation of weight and less predisposition to weight control.
Revisiting phage therapy: new applications for old resources
Nóbrega, Franklin Luzia; Costa, A. R.; Kluskens, Leon; Azeredo, JoanaThe success of phage therapy is dependent on the development of strategies able to overcome the limitations of bacteriophages as therapeutic agents, the creation of an adequate regulatory framework, the implementation of safety protocols, and the acceptance by the general public. Many approaches have been proposed to circumvent phages intrinsic limitations but none have proved to be completely satisfactory. In ...
Feed optimization in fed-batch culture
Costa, A. R.; Rodrigues, E.; Henriques, Mariana; Oliveira, Rosário; Azeredo, JoanaFed-batch processes are a current preference for the production of recombinant proteins in mammalian cells. The use of nutrient feeding prevents the depletion of important medium components, and results in improved culture longevity and high cell and product yields. To take maximum advantage of these effects, it is important to optimize the fed-batch process for each application. In this chapter, a simple strat...