55 documents found, page 1 of 6
Synthetic biology to engineer bacteriophage genomes
Costa, Ana Rita; Azeredo, Joana; Pires, Diana Priscila PensoRecent advances in the synthetic biology field have enabled the development of new molecular biology techniques used to build specialized bacteriophages with new functionalities. Bacteriophages have been engineered toward a wide range of applications, including pathogen control and detection, targeted drug delivery, or even assembly of new materials. In this chapter, two strategies that have been successfully u...
Surgical Management Of Congenital Thoracic Disorders: A 15-Year Center Experience
Pereira Moita, Catarina; Figueiredo, Catarina; Cruz, Zenito; Maciel, João; Costa, Ana Rita; Santos Silva, João; Reis, João Eurico; Calvinho, PauloIntroduction: Congenital thoracic disorders represent a spectrum of fetal lung bud development abnormalities, which may affect breathing capacity and quality of life. We aim to evaluate the impact of surgery in the treatment of 4 major congenital conditions. Materials and Methods: We performed a retrospective cohort analysis of patients who underwent surgical treatment in our tertiary center, from 2007 to 2022....
Segmentectomies: 5-Year Experience Of A Center
Nunes Figueiredo, Catarina; Moita, Catarina; Cruz, Zenito; Costa, Ana Rita; Santos Silva, João; Reis, João Eurico; Maciel, João; Calvinho, PauloIntroduction: Segmental anatomical resections have been a subject of debate in recent years. There is increasing evidence that these procedures may offer some advantages in the treatment of early-stage lung cancer, with overall survival (OS) and disease-free survival (DFS) similar to those seen in lobar anatomical resections. Materials and Methods: We conducted a retrospective analysis of patients who underwent...
Pancoast Tumors: 11-Year Single-Centre Experience
Pereira Moita, Catarina; Figueiredo, Catarina; Cruz, Zenito; Costa, Ana Rita; Maciel, João; Santos Silva, João; Eurico Reis, João; Calvinho, PauloIntroduction: Pancoast tumors encompass any tumor located on the lung apex, extending into structures in the thoracic inlet and, often, leading to the characteristic clinical syndrome. The main goal of this study is to analyze the response to multimodal treatment and outcome of patients with Pancoast tumors. Materials and Methods: We performed a retrospective cohort single center study of patients with superior...
Toxicity of the 3,4-methylenedioxymethamphetamine and its enantiomers to Daphni...
Costa, Ana Rita; Gonçalves, Virgínia M. F.; Castro, Bruno B.; Carrola, João Soares; Langa, Ivan; Pereira, Ariana; Carvalho, Ana RitaMDMA (3,4-methylenedioxymethamphetamine) is a chiral psychoactive recreational drug sold in illicit markets as racemate. Studies on the impact of MDMA on aquatic organisms are scarce. While enantioselectivity in toxicity in animals and humans has been reported, none is reported on aquatic organisms. This study aimed to investigate the ecotoxicological effects of MDMA and its enantiomers in <i>Daphnia magna</i>....
Olive and sunflower cakes as suitable substrates for lipase production by Yarro...
Costa, Ana Rita; Salgado, José Manuel; Belo, IsabelSolid state fermentation is a biotechnological process that allows the utilization of agro-industrial by-products as solid substrates for the growth of microorganisms, including filamentous fungi and yeasts, with the simultaneous production of added value compounds, like enzymes. Oil cakes, such as olive and sunflower cakes, are generated during vegetable oil extraction and have received great interest as solid...
Solid state and semi-solid fermentations of olive and sunflower cakes with Yarr...
Costa, Ana Rita; Fernandes, Helena; Salgado, José Manuel; Belo, IsabelLignocellulosic biomass is a promising feedstock for added value compound production in biotechnological processes such as solid-state fermentation (SSF). Although these solid materials can be directly used as substrates in fermentations in a solid state, a pretreatment is often required, especially if the microorganism selected is unable to produce lignocellulosic enzymes. In the present work, several pretreat...
Teachers´ voices on a project to raise linguistic diversity awareness in primar...
Costa, Ana RitaSem resumo disponível.
Yarrowia lipolytica as a biorefinery platform for effluents and solid wastes va...
Lopes, Marlene; Miranda, Sílvia Cristiana Martins; Costa, Ana Rita; Pereira, Ana Sofia Silva; Belo, IsabelDue to its physiological and enzymatic features, Yarrowia lipolytica produces several valuable compounds from a wide range of substrates. Appointed by some authors as an industrial workhorse, Y. lipolytica has an extraordinary ability to use unrefined and complex low-cost substrates as carbon and nitrogen sources, aiding to reduce the waste surplus and to produce added-value compounds in a cost-effective way. D...
Valorization of by-products from vegetable oil industries: Enzymes production b...
Costa, Ana Rita; Salgado, José Manuel; Lopes, Marlene; Belo, IsabelVegetable oil extraction generates high amounts of by-products, which are designated as oil cakes. Since the current strategies employed for oil cakes reuse are linked with some drawbacks, identification of alternative approaches to decrease the environmental impact and promote a circular economy is of vital importance. In general, these materials are characterized by high fiber content, making them suitable to...