13 documents found, page 1 of 2
Dhvar5-chitosan nanogels and their potential to improve antibiotics activity
Costa, B; Alves, PM; Fonseca, DR; Campos, F; Monteiro, AC; Shahrour, H; Gomes, A; Costa, F; Gomes, P; Martínez-de-Tejada, G; Monteiro, C; Martins, MCLInfection is one of the main causes of orthopedic implants failure, with antibiotic-resistant bacteria playing a crucial role in this outcome. In this work, antimicrobial nanogels were developed to be applied in situ as implant coating to prevent orthopedic-device-related infections. To that regard, a broad-spectrum antimicrobial peptide, Dhvar5, was grafted onto chitosan via thiol-norbornene "photoclick" chemi...
Dhvar5- and MSI78-coated titanium are bactericidal against methicillin-resistan...
Costa, B; Coelho, J; Silva, V; Shahrour, H; Costa, NA; Ribeiro, AR; Santos, SG; Costa, F; Martínez-de-Tejada, G; Monteiro, C; Martins, MCLInfection is one of the major issues associated with the failure of orthopedic devices, mainly due to implant bacterial colonization, biofilm formation, and associated antibiotic resistance. Antimicrobial peptides (AMP) are a promising alternative to conventional antibiotics given their broad-spectrum of activity, low propensity to induce bacterial resistance, and ability to modulate host immune responses. Dhva...
Load Tests on Bridges
Mário Jorge Pimentel; Figueiras, J; Félix, C; Cavadas, F; Tomé, E; Rodrigues, C; Costa, BThis chapter presents an overview on the state-of-the-art procedures for load tests on bridges and on the applicable sensing and data acquisition technologies. Best practices for the planning, preparation and execution of load tests are presented. The discussion is supported by practical applications in which the authors have been involved during the last 20 years. Selected case studies are used to illustrate t...
Thiol-Norbornene Photoclick Chemistry for Grafting Antimicrobial Peptides onto ...
Alves, PM; Pereira, RF; Costa, B; Tassi, N; Teixeira, C; Leiro, V; Monteiro, C; Gomes, P; Costa, F; Martins, MCLCovalent conjugation of antimicrobial peptides (AMP) is considered an effective approach to overcome their potential degradation in vivo. As the high cost of AMP-based therapies is one of the major hurdles towards their clinical application, it is urgently needed to explore high yield reactions. Herein, the highly efficient thiol-norbornene photoclick chemistry (TNPC) was explored for AMP grafting onto chitosan...
New insight into breast cancer cells involving drug combinations for dopamine a...
Costa, B; Matos, R; Amorim, I; Gärtner, F; Vale, NThe breast cancer therapies available are insufficient, especially since first-line treatments, such as paclitaxel, result in drug resistance and their toxicity often limits their concentration. Strategies like drug repurposing are beneficial, and novel treatments can emerge by repurposing drugs that interfere with the dopamine and serotonin receptors, and thus influence tumor growth. In this study, the MTT ass...
Antimicrobial peptides in the battle against orthopedic implant-related infecti...
Costa, B; Martínez-De-tejada, G; Gomes, PAC; Martins, MCL; Costa, FPrevention of orthopedic implant-related infections is a major medical challenge, particularly due to the involvement of biofilm-encased and multidrug-resistant bacteria. Current therapies, based on antibiotic administration, have proven to be insufficient, and infection prevalence may rise due to the dissemination of antibiotic resistance. Antimicrobial peptides (AMPs) have attracted attention as promising sub...
Natural cyanobacterial polymer-based coating as a preventive strategy to avoid ...
Costa, B; Mota, R; Tamagnini, P; Martins, CML; Costa, FCatheter-associated urinary tract infections (CAUTIs) represent about 40% of all healthcare-associated infections. Herein, the authors report the further development of an infection preventive anti-adhesive coating (CyanoCoating) meant for urinary catheters, and based on a natural polymer released by a marine cyanobacterium. CyanoCoating performance was assessed against relevant CAUTI etiological agents, namely...
Broad-spectrum anti-adhesive coating based on an extracellular polymer from a m...
Costa, B; Mota, R; Parreira, P; Tamagnini, P; Martins, MCL; Costa, FMedical device-associated infections are a major health threat, representing about half of all hospital-acquired infections. Current strategies to prevent this problem based on device coatings with antimicrobial compounds (antibiotics or antiseptics) have proven to be insufficient, often toxic, and even promoting bacterial resistance. Herein, we report the development of an infection-preventive coating (CyanoCo...
Relationship Between Bioimpedance-Determined Body Composition and Peritoneal Tr...
Costa, B; Del Peso, G; Bajo, MA; Carreño, G; Ferreira, M; Ferreira, C; Selgas, RPURPOSE: In peritoneal dialysis (PD) patients, body fluid homeostasis is dependent on peritoneal elimination of water and solutes. Patients with less favorable peritoneal transport parameters should be more overhydrated. Despite this, the association between faster transport and overhydration (OH) is weak, and the factors that influence hydration status are still poorly characterized. Modified peritoneal equili...
Q Fever Chronic Osteomyelitis in Two Children
Costa, B; Morais, A; Santos, AS; Tavares, D; Seves, G; Gouveia, CWe report 2 cases of chronic Q fever osteomyelitis in 10- and 5-year-old girls who presented with distal right femoral and left parasternal granulomatous osteomyelitis, respectively. Both were treated with ciprofloxacin and rifampin with good response. Q fever osteomyelitis is a challenging diagnosis in children, and the choice of antimicrobial treatment is difficult because of limited available data.