44 documents found, page 1 of 5
Otimização de fluxo de dados em uma rede de sensores utilizando a técnica de co...
Costa, Bruno MarquesSubmitted by Boris Flegr (boris@uerj.br) on 2021-01-05T17:54:56Z No. of bitstreams: 1 DissertacaoBrunoMarquesCosta.pdf: 13932298 bytes, checksum: 8634338eac109a40fe109e7113eb524b (MD5); Made available in DSpace on 2021-01-05T17:54:56Z (GMT). No. of bitstreams: 1 DissertacaoBrunoMarquesCosta.pdf: 13932298 bytes, checksum: 8634338eac109a40fe109e7113eb524b (MD5) Previous issue date: 2017-11-28; Wireless sensor net...
The role of network science in glioblastoma
Lopes, Marta B.; Martins, Eduarda P.; Vinga, Susana; Costa, Bruno MarquesNetwork science has long been recognized as a well-established discipline across many biological domains. In the particular case of cancer genomics, network discovery is challenged by the multitude of available high-dimensional heterogeneous views of data. Glioblastoma (GBM) is an example of such a complex and heterogeneous disease that can be tackled by network science. Identifying the architecture of molecula...
A new chalcone derivative with promising antiproliferative and anti-invasion ac...
Mendanha, Daniel; Castro, Joana Isabel Martins Cosme Vieira; Moreira, Joana; Costa, Bruno Marques; Cidade, Honorina; Pinto, MadalenaGlioblastoma (GBM) is the most common and most deadly primary malignant brain tumor. Current therapies are not effective, the average survival of GBM patients after diagnosis being limited to few months. Therefore, the discovery of new treatments for this highly aggressive brain cancer is urgently needed. Chalcones are synthetic and naturally occurring compounds that have been widely investigated as anticancer ...
Intracellular autofluorescence as a new biomarker for cancer stem cells in glio...
Castro, Joana Isabel Martins Cosme Vieira; Gonçalves, Celine Saraiva; Martins, Eduarda P.; Miranda-Lorenzo, Irene; Cerqueira, Mariana TeixeiraThe identification of cancer stem cells (CSCs), which are implicated in tumor initiation, progression, therapy resistance, and relapse, is of great biological and clinical relevance. In glioblastoma (GBM), this is still a challenge, as no single marker is able to universally identify populations of GBM cancer stem cells (GSCs). Indeed, there is still controversy on whether biomarker-expressing cells fulfill the...
Exploiting the complexities of glioblastoma stem cells: insights for cancer ini...
Vieira de Castro, Joana; Gonçalves, Celine Saraiva; Hormigo, Adília; Costa, Bruno MarquesThe discovery of glioblastoma stem cells (GSCs) in the 2000s revolutionized the cancer research field, raising new questions regarding the putative cell(s) of origin of this tumor type, and partly explaining the highly heterogeneous nature of glioblastoma (GBM). Increasing evidence has suggested that GSCs play critical roles in tumor initiation, progression, and resistance to conventional therapies. The remarka...
Unravelling the anticancer potential of functionalized chromeno[2,3-b ] pyridin...
Oliveira-Pinto, Sofia; Pontes, Olivia; Lopes, Diogo; Marques, Maria Belém Sousa Sampaio; Costa, Marta D.; Carvalho, Luisa; Goncalves, Celine S.A selection of new chromeno[2,3-b]pyridines was prepared from chromenylacrylonitriles and N-substituted piperazines, using a novel and efficient synthetic procedure. The compounds were tested for their anticancer activity using breast cancer cell lines MCF-7, Hs578t and MDA-MB-231 and the non-neoplastic cell line MCF-10A for toxicity evaluation. In general, compounds showed higher activity towards the luminal b...
Sirtuins’ deregulation in bladder cancer: SIRT7 is implicated in tumor progress...
Monteiro-Reis, Sara; Lameirinhas, Ana; Miranda-Gonçalves, Vera; Felizardo, Diana; Dias, Paula C.; Oliveira, Jorge; Graça, InêsSirtuins are emerging players in cancer biology and other age-related disorders, and their putative role in bladder cancer (BlCa) remains elusive. Further understanding of disease biology may allow for generation of more effective pathway-based biomarkers and targeted therapies. Herein, we aimed to illuminate the role of sirtuins’ family in BlCa and evaluate their potential as disease biomarkers and therapeutic...
Serum lactate levels are associated with glioma malignancy grade
Branco, Mariana; Linhares, Paulo; Carvalho, Bruno; Santos, Patrícia; Costa, Bruno Marques; Vaz, RuiObjective Recent studies have suggested that high grade gliomas are associated with elevated serum lactate concentrations. The aim of the present study is to assess these findings in a sample of patients. Patients and methods We reviewed the anesthetic charts of patients with low-grade and high-grade glioma who underwent resection surgery and collected serum lactate concentration before tumor resection, as well...
Overexpression of circulating MiR-30b-5p identifies advanced breast cancer
Estevão-Pereira, Helena; Lobo, João; Salta, Sofia; Amorim, Maria; Lopes, Paula; Cantante, Mariana; Reis, Berta; Antunes, Luís; Castro, FernandoBreast cancer (BrC) remains the leading cause of cancer-related death in women, mainly due to recurrent and/or metastatic events, entailing the need for biomarkers predictive of progression to advanced disease. MicroRNAs hold promise as noninvasive cancer biomarkers due to their inherent stability and resilience in tissues and bodily fluids. There is increasing evidence that specific microRNAs play a functional...
The long non-coding RNA HOTAIR is transcriptionally activated by HOXA9 and is a...
Xavier-Magalhães, Ana; Gonçalves, Céline S; Fogli, Anne; Lourenço, Tatiana; Pojo, Marta; Pereira, Bruno; Rocha, Miguel; Celeste Lopes, MariaThe lncRNA HOTAIR has been implicated in several human cancers. Here, we evaluated the molecular alterations and upstream regulatory mechanisms of HOTAIR in glioma, the most common primary brain tumors, and its clinical relevance. HOTAIR gene expression, methylation, copy-number and prognostic value were investigated in human gliomas integrating data from online datasets and our cohorts. High levels of HOTAIR w...