184 documents found, page 1 of 19
Predictors of myositis in mixed connective tissue disease: a multicentre retros...
Melo, A. T.; António, M. Silvério; Martinho, J. Martins; Guimarães, F.; Dourado, E.; Oliveira, D.; Lopes, J.; Saraiva, A.; Gago, A.; Correia, M.Objectives: We aimed to identify clinical and serological predictors of myositis in mixed connective tissue disease (MCTD). Methods: We performed a nationwide, retrospective, multicentre study including adult-onset MCTD patients fulfilling at least one of the following diagnostic criteria: Sharp’s, Kasukawa, Alarcón-Segovia, or Kahn’s. Univariable analysis was performed using Chi-square, Fisher exact, Student’s...
CONTROLO NATURAL DO PARASITISMO GASTROINTESTINAL EM CAPRINOS E EFEITO NA CONTAM...
Belo, A. T.; Ribeiro, J.M.B.F.; Barbas, J.P.; Cavaco-Gonçalves, S.; Belo, C.C.; Costa, C.; Belo, J.; Padre, L.Na perspetiva de um controlo integrado, é importante o estudo de métodos alternativos ao uso exclusivo de anti‑helmínticos sintéticos, e privilegiar tratamentos seletivos.
Factors influencing free and open-source software adoption in developing countr...
Silva, D.; Coutinho, C.; Costa, C.Free Open-Source Software (FOSS) is essentially seen by many organizations as a key pillar for accelerating technological innovation. This study aims to evaluate the extent to which factors such as cost and quality of the system, as well as usability, interoperability, and security, influence the intention to use FOSS. Based on the data obtained from the survey, we propose a new theoretical model that we test a...
Luxury tourism from the traditional perspective to the sustainable trigger: Red...
Santos, V. R.; Au-Yong-Oliveira, M.; Sousa, M.; Costa, C.This study analyses and explores the origins of the concept of luxury tourism and its ongoing evolution. A focus group was chosen as the field research method to collect primary data in order to explore and discuss the redefinition of new luxury tourism from different complementary perspectives. The central outcomes indicate that the concept of luxury tourism has changed over time. In recent years, it has advan...
Molecular characterisation of cutaneous melanoma
Nunes, I.; Costa, C.; Martin, C.; Andrade, M. I.; João, A.; Lopes, J. M.; Barata, C.; Soares, Paula; Populo, H.Introduction: Cutaneous melanoma (CM) is the least frequent but deadliest kind of skin cancer, highlighting the aggressiveness of these tumors. As a result of prolonged exposure to UV radiation, CM harbors one of the highest mutation rates among all malignancies. The three most common mutations occur in BRAF and NRAS genes, both important for the mitogen-activated protein kinase pathway upregulation, and in the...
Utility of salivary leucocytes for biomonitoring of human exposure to nanomater...
Valdiglesias, Vanessa; Fernández-Bertólez, Natália; Touzani, A.; Mendéz, J.; Martinez, L.; Pásaro, E.; Reis, A.T.; Fraga, S.; Teixeira, J.P.; Costa, C.Metal-based nanoparticles (NP) are being increasingly used in a wide variety of applications in consumer products and biomedical practices. As a result, human exposure to these nanomaterials is frequent, becoming a concern to public health. Human salivary leucocytes have been proposed as a proper biological sample for the comet assay, becoming an adequate non-invasive alternative model to evaluate DNA damage. I...
Indoor levels and health risk assessment of volatile organic compounds in Portu...
Slezakova, K.; Costa, C.; Valongo, C.; Teixeira, J.P.; Madureira, J.About indoor levels and health risk assessment of volatile organic compounds in Portuguese homes.
Impact of renovations on EDC levels and school children's health: bridging scie...
Hatem, G.; Salamova, A.; Haninnen, O.; Faria, A.M.; Costa, C.; Slezakova, K.; Teixeira, J.P.; Madureira, J.Building renovations may yield emissions of various air chemicals that can disrupt normal human endocrine functions. However, only a few endocrine disruptive health outcomes (e.g., respiratory, behavioural, or learning domains) have been comprehensively addressed among susceptible populations, particularly schoolchildren. This project investigates the role of school building renovations on childrenís exposure t...
Viability assay and DNA double strand break induction in nervous system cells e...
Fernandez-Bertolez, N.; Touzani, A.; Martinez, L.; Méndez, J.; Ramos-Paz, L.; Reis, A.T.; Fraga, S.; Costa, C.; Teixeira, J.P.; Pásaro, E.Cerium dioxide nanoparticles (CeO2 NP) show antioxidant enzyme mimetic properties and free radical scavenging activity. These properties make them a promising material for biomedical applications, but their potential adverse effects are not totally understood yet. Our objective was to assess the biological behaviour of CeO2 NP in human neuronal and glial cells. After carrying out the physical-chemical character...
Lucha contra las especies invasoras: prácticas STEAM y conservación de la biodi...
Costa, S. L.; Rodrigues, M.; Martins, F.; Lopes, J. B.; Sá-Pinto, X.; Cardoso, Inês; Costa, C.Las especies invasoras son una de las principales amenazas para la conservación de la biodiversidad en todo el mundo; Portugal no es una excepción. Es esencial cambiar las actitudes y el comportamiento de la población, minimizando la introducción, dispersión y establecimiento de estas especies. La escuela puede contribuir a fomentar comportamientos proambientales en los estudiantes y, cuando está abierta a la c...