166 documents found, page 1 of 17
Dual modulation of cytotoxic and checkpoint receptors tunes the efficacy of ado...
Blanco Dominguez, Rafael; Barros, Leandro; Carreira, Mariana; van der Ploeg, Manon; Condeço, Carolina; Marsères, Gabriel; Ferreira, CristinaColorectal cancer (CRC) remains a challenge for current immunotherapies. Vδ1+ γδ T cells offer a promising alternative because of their HLA-I-independent cytotoxicity and natural tissue tropism. We developed Delta One T (DOT) cells, a Vδ1+ γδ T cell-based adoptive cell therapy clinically explored for hematological malignancies but not yet for solid tumors. Here we demonstrate the capacity of DOT cells to target...
Occupational exposure to wildland firefighting and its effects on systemic DNA ...
Esteves, Filipa; Madureira, Joana; Costa, Carla; Pires, Joana; Barros, Bela; Alves, Sara; Vaz, Josiana; Oliveira, Marta; Slezakova, KlaraBackground: Portugal is among the European Union countries more devastated by forest fires. Wildland firefighters are at the forefront of this battle, facing exposure to a wide range of harmful pollutants. Epidemiological studies have highlighted a potential link between occupational firefighting exposure and several diseases, including cancer. To date, very few studies have explored the biological mechanisms a...
Diagnóstico em Saúde Escolar - Alimentação e Atividade Física
Coelho, Fernanda; Costa, Carla; Meireles, Juliana; Neves, NazaréEnquadramento: Enquadramento: No âmbito do Observatório de Saúde, a USP do ACES VSN, realizou um estudo com o objetivo de conhecer os hábitos alimentares (1,2) e a prática da atividade física (3) das crianças e jovens do pré-escolar ao ensino secundário das escolas públicas da área de influência do ACES. Objetivos: Avaliar o Índice de Massa Corporal dos alunos, conhecer os hábitos alimentares e avaliar a prátic...
General knowledge and attitudes about safety and emergency evacuation: the case...
Carvalhais, Carlos; Dias, Ricardo; Costa, Carla; Vieira da Silva, ManuelaThe implementation of a safety culture and awareness of emergency issues in buildings has been growing in more developed societies. It is essential that all occupants know how to act in an emergency situation, particularly during an emergency evacuation. In higher education institutions (HEIs), which annually host not only their many employees, but also national and international students, it is essential to kn...
Passive tobacco smoke exposure and children’s health outcomes: a preliminary an...
Faria, Ana Margarida; Hatem, Georges; Bessa Pinto, Mariana; Teixeira, João Paulo; Slezakova, Klara; Pereira, Maria do Carmo; Costa, CarlaBackground: Children’s exposure to Passive Tobacco Smoke (PTS) in utero and during infancy can increase the risk of childhood respiratory diseases and infections (e.g., otitis) [1-3]. Objective: This study explores the association between children’s exposure to PTS in utero (maternal, frequent smoking family member during pregnancy), up to one year, and current maternal smoke exposure with, to date, and the fir...
Evidence on the relationship between airborne exposure to endocrine-disrupting ...
Hatem, Georges; Faria, Ana Margarida; Bessa, Mariana Pinto; Teixeira, João Paulo; Costa, Carla; Madureira, JoanaBackground: Evaluating airborne exposure to endocrine-disrupting chemicals (EDCs) in children is paramount, given their vulnerability, which can lead to enduring health impacts such as asthma-related outcomes [1]. Objective: This systematic review aims to identify existing scientific evidence assessing airborne exposure to EDCs among school-age children and asthma onset or exacerbation. Methods: This review adh...
Self-reported dermal effects of hand sanitisers in industrial workers
Costa, Carla; Carvalhais, C.; Domingos, C.; Oliveira, A.; Santos, J.Background: During COVID-19 pandemic, preventing the virus spread was extremely important to reduce the overall burden of the disease, to maintain the companies running and to remain safe. WHO recommended physical distances, appropriate use of personal protective equipment and hand hygiene practices to reduce the spread. Hand hygiene practice by using alcohol-based hand sanitisers was generalized in all sectors...
Biocompatibility evaluation of CeO2 nanoparticles to be employed as nanodrugs i...
Fernández-Bertólez, Natália; Touzani, Assia; Martínez, L.; Reis, Ana Teresa; Fraga, Sónia; Teixeira, João Paulo; Costa, Carla; Pásaro, EduardoCerium dioxide nanoparticles (CeO2NP) have recently gained attention for their unique structure-dependent properties, antioxidant enzyme-like behaviour, ROS scavenging activity and great potential for biomedical applications. In addition to their antioxidant and anti-inflammatory activity, CeO2NP are also known to exhibit anticancer potential, providing an attractive opportunity for use in cancer therapy, as a ...
Azadirachta indica A. Juss (neem) phenolic extract inhibits human B-lymphoblast...
Santos, Klebson Silva; Costa, Carla; Bessa, Maria João; Teixeira, João Paulo; Muniz, Ana Veruska Cruz da Silva; Padilha, Francine FerreiraAim: As far as is known, the pharmaceutical effects of neem on human B-lymphoblastoid (TK6) cells have not been studied until now. Hence, the present study aimed to obtain neem phenolic extracts for inhibits the proliferation of TK6 cells and explore some possible underlying mechanisms involved in these effects. Methods: Hexane extract (HE) was obtained in the first step. After that, the residual hexane was rem...
The Toxicity of Nanomaterials and Legacy Contaminants: Risks to the Environment...
Reis, Ana Teresa; Costa, Carla; Fraga, SóniaNanotechnology and the incorporation of nanomaterials (NM) into everyday products help to solve problems in society and improve the quality of life, allowing for major advances in the technological, industrial, and medical fields. Despite this positive and encouraging side of nanotechnology, the potential risks of NM to human health and the environment, as well as the ethical, legal, and social implications ass...