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Intranasal delivery of nanostructured lipid carriers, solid lipid nanoparticles...
Costa, Cláudia Pina; Moreira, João Nuno; Sousa Lobo, José Manuel; Silva, Ana CatarinaThe management of the central nervous system (CNS) disorders is challenging, due to the need of drugs to cross the blood‒brain barrier (BBB) and reach the brain. Among the various strategies that have been studied to circumvent this challenge, the use of the intranasal route to transport drugs from the nose directly to the brain has been showing promising results. In addition, the encapsulation of the drugs in ...
Application of the Quality-by-Design (QbD) approach to improve the nose-to-brai...
Costa, Cláudia Pina; Cunha, Sara; Peixoto, Andreia F.; Moreira, João Nuno; Lobo, José Manuel Sousa; Silva, Ana CatarinaThe intranasal administration of nanostructured lipid carriers (NLCs) has been suggested as a promising strategy to improve the fast treatment of epilepsy. This route allows for drug passage directly from the nose to the brain, avoiding the need of bypassing the blood–brain barrier. In addition, the quality-by-design (QbD) approach is a useful tool for the optimization of manufacturing variables, resulting in e...
Intranasal delivery of nanostructured lipid carriers, solid lipid nanoparticles...
Costa, Cláudia Pina; Moreira, João Nuno; Lobo, José Manuel Sousa; Silva, Ana CatarinaThe management of the central nervous system (CNS) disorders is challenging, due to the need of drugs to cross the blood‒brain barrier (BBB) and reach the brain. Among the various strategies that have been studied to circumvent this challenge, the use of the intranasal route to transport drugs from the nose directly to the brain has been showing promising results. In addition, the encapsulation of the drugs in ...
Double optimization of rivastigmine-loaded Nanostructured Lipid Carriers (NLC) ...
Cunha, Sara; Costa, Cláudia Pina; Loureiro, Joana A.; Alves, Jorge; Peixoto, Andreia F.; Forbes, Ben; Sousa Lobo, José Manuel; Silva, Ana CatarinaRivastigmine is a drug commonly used in the management of Alzheimer's disease that shows bioavailability problems. To overcome this, the use of nanosystems, such as nanostructured lipid carriers (NLC), administered through alternative routes seems promising. In this work, we performed a double optimization of a rivastigmine-loaded NLC formulation for direct drug delivery from the nose to the brain using the qua...
Using the quality by design (QbD) approach to optimize formulations of lipid na...
Cunha, Sara; Costa, Cláudia Pina; Moreira, João Nuno; Lobo, José Manuel Sousa; Silva, Ana CatarinaQuality-by-design (QbD) approach has been applied to optimize lipid-based nanosystems formulations, including solid lipid nanoparticles (SLN), nanostructured lipid carriers (NLC) and nanoemulsions, besides being increasingly requested by regulatory authorities. Different mathematical models and statistical tests have been used, with similar conclusions regarding the parameters that influence the physical featur...
Hormones, blood products, and therapeutic enzymes
Silva, Ana Catarina; Costa, Cláudia Pina; Almeida, Hugo; Moreira, João Nuno; Lobo, José Manuel SousaTherapeutic uses of biological medicines are diverse and include active substances from different classes. This chapter provides an overview on the clinical applications of biological medicines containing hormones, blood products, and therapeutic enzymes. Currently, therapeutic hormones have 78 approved medicines, including insulin and analogs, glucagon and analogs, growth hormone, gonadotropins (follicle-stimu...