7 documents found, page 1 of 1
Relação entre Helicobacter pylori, metilação gênica e polimorfismos genéticos d...
Costa, Débora Menezes daCOSTA, D. M. Relação entre helicobacter pylori, metilação gênica e polimorfismos genéticos do hospedeiro no câncer gástrico. 2016. 99 f. Tese (Doutorado em Microbiologia Médica) - Faculdade de Medicina, Universidade Federal do Ceará, Fortaleza, 2016.; Gastric cancer is a serious health problem. Several risk factors have been identified to contribute to its development, such as virulence genes of H. pylori, SNPs...
Association of the polymorphism in DNA repair enzymes and E-Cadherin gene with ...
Pereira, Eliane dos Santos; Silva-Fernandes, Isabelle Joyce de Lima; Costa, Débora Menezes da; Burbano, Rommel Mario RodriguezSNPs have been associated with gastric cancer susceptibility. Thus, we evaluated the influence of SNPs in DNA repair genes APE1 2197(T>G) and MLH1 -93(G>A), as well as in CDH1 at positions -160 (C>A) and -347 (G>GA) in gastric cancer risk. Analyses were performed on 264 GC patients and 391 healthy controls matched by age and sex from two regions in Brazil, Ceará and Pará. In the general analysis, a protective w...
Characterization of gastric cardia tumors : differences in Helicobacter pylori ...
Costa, Débora Menezes da; Pereira, Eliane dos Santos; Silva- Fernandes, Isabelle Joyce de Lima; Ferreira, Márcia Valéria PitombeiraBackground Gastric cancer results from a multifactorial process and is one of the most common causes of death worldwide. These tumors can arise in the distal stomach (non-cardia) and in the cardia region, presenting different characteristics and frequency of occurrence worldwide. Aims To search for differences between tumors of dif- ferent locations that could explain the presence of cardia tumors, considering ...
What exists beyond cagA and vacA? Helicobacter pylori genes in gastric diseases
Costa, Débora Menezes da; Pereira, Eliane dos Santos; Barem Rabenhorst, Silvia HelenaThe Helicobacter pylori (H. pylori) infection is present in more than half the world’s population and it has been associated with several gastric disorders, as gastritis, peptic ulceration and gastric adenocarcinoma. The clinical outcome of this infection depends on host and bacterium factors where H. pylori virulence genes seem to play a relevant role. Until now, cagA and vacA genes were studied and establishe...
Associação entre Helicobacter pylori e polimorfismos em genes de interleucinas ...
Costa, Débora Menezes daThe carcinogenic role of Helicobacter pylori is related to its ability to promote inflammation and, consequently, DNA methylation, epigenetic trait often associated with gastric carcinogenesis. In turn, the inflammation can be modulated by the presence of polymorphisms in some interleukin genes, as well as the bacterial genotype. The objectives of this study were: a) link the genotypic profile of H. pylori viru...
Associations of polymorphisms of folate cycle enzymes and risk of breast cancer...
Barbosa, Rita de Cássia Carvalho; Costa, Débora Menezes da; Freire, Thiago Fernando Vasconcelos; Sales, Diogo Campos; Alencar, Victor Hugo MedeirosPolymorphisms in genes involved in folate metabolism have been shown to be implicated in breast cancer risk but with contradictory results. In this case– control study, we investigated the association between MTHFR C677T and A1298C, TYMS 5 0 -UTR, MTR A2756G and c SHMT C1420T and also the folate carrier ( RFC1 G80A) and breast cancer risk in a northeastern Brazilian population. The study included 183 women diag...
Polymorphisms of folate pathway enzymes (Methylenetetrahydrofolate reductase an...
Costa, Débora Menezes da; Lima, Germano Paulo Venceslau de; Faria, Mário Henrique Girão; Rabenhorst, Silvia Helena Baremwo important polymorphisms of folate cycle enzymes, methylenetetrahydrofolate reductase ( MTHFR) C677T and thymidylate synthase (TS) enhancer region (TSER) 28-bp tandem repeat, are related to risk of various types of cancer, including brain tumors, although there are few studies on this subject. A case–control study of these two polymorphisms in astrocytomas of different grades was carried out using polymerase ...