16 documents found, page 1 of 2
Different source of commercial vegetable oils may regulate metabolic, inflammat...
Gomes, Sttefany Viana; Dias, Bruna Vidal; Pereira, Renata Rebeca; Lúcio, Karine de Pádua; Souza, Débora Maria Soares de; Silva, André Talvani Pedrosa daOur goal was to carry out a comparative study to evaluate the metabolic and inflammatory effects and the redox status of commercial vegetable oils supplementation [linseed (LO), coconut (VCO), and sunflower (SO)] in metabolically healthy rats. The results found in this study showed that the LO group decreased the HOMA-IR and hepatic cholesterol, and increased the serum levels of IL-6. Supplementation with VCO i...
Anti-Inflammatory and antioxidant properties of black mulberry (Morus nigra L.)...
Lúcio, Karine de Pádua; Rabelo, Ana Carolina Silveira; Araújo, Carolina Morais; Brandão, Geraldo Célio; Souza, Gustavo Henrique Bianco deSepsis is a complex disease and is the cause of many deaths worldwide. Sepsis pathogenesis involves a dysregulated inflammatory response with consequent production of inflammatory mediators and reactive species. The production and excessive release of these substances into the systemic circulation trigger various cellular and metabolic alterations that are observed during the disease evolution. Thus, more studi...
Preparation and characterization of a quercetin-tetraethyl ether-based photopro...
Gonçalves, Marlucy da Cruz; Santos, Viviane Martins Rebello dos; Taylor, Jason Guy; Perasoli, Fernanda Barçante; Santos, Orlando David Henrique dosAlthough Quercetin absorbs in the UVA/UVB electromagnetic region, it is limited for applications as a UV filter due to its low lipophilicity and capacity to penetrate the epidermis. In order to overcome this limitation, we synthetized and evaluated the photo protective properties of a derivative obtained from Quercetin. The derivative was prepared by alkylation of Quercetin with iodoethane and characterized by ...
Aqueous extract of Baccharis trimera improves redox status and decreases the se...
Rabelo, Ana Carolina Silveira; Araújo, Glaucy Rodrigues de; Lúcio, Karine de Pádua; Araújo, Carolina Morais; Miranda, Pedro Henrique de AmorimThe metabolism of ethanol occurs mainly in the liver, promoting increase of reactive oxygen species and nitrogen, leading to redox imbalance. Therefore, antioxidants can be seen as an alternative to reestablish the oxidizing/reducing equilibrium. The aim of this study was to evaluate the antioxidant and hepatoprotective effect of aqueous extract of Baccharis trimera (Less.) DC., Asteraceae, in a model of hepato...
Estudos preliminares da citoxicidade e propriedades fotoprotetoras de derivados...
Gonçalves, Marlucy da Cruz; Taylor, Jason Guy; Rossoni Júnior, Joamyr Victor; Rabelo, Ana Carolina Silveira; Costa, Daniela Caldeira; Cazati, ThiagoA Radiação solar ultravioleta(RUV) pode induzir efeitos à pele devidos a sua ação direta ou indireta, por meio da geração de radicais livres. Esses efeitos podem provocar diversas lesões na pele humana como o câncer de pele. Como medida de proteção da pele contra os efeitos da radiação solar pode-se citar o uso de protetores solares, produtos tópicos adicionados de filtros solares UV sintéticos com propriedades...
Baccharis trimera (Carqueja) Improves metabolic and redox status in an experime...
Kaut, Natália Nogueira do Nascimento; Rabelo, Ana Carolina Silveira; Araújo, Glaucy Rodrigues de; Taylor, Jason Guy; Silva, Marcelo EustáquioDiabetes mellitus is a metabolic disorder that causes severe complications due to the increased oxidative stress induced by disease. Many plants are popularly used in the treatment of diabetes, e.g., Baccharis trimera (carqueja). The aim of this study was to explore the potential application of the B. trimera hydroethanolic extract in preventing redox stress induced by diabetes and its hypoglycemic properties. ...
Oral formulation of DPP-4 inhibitor plus Quercetin improves metabolic homeostas...
Miranda, Pedro Henrique de Amorim; Lacerda, Kíssyla Christine Duarte; Araújo, Carolina Morais; Barichello, José Mario; Lima, Wanderson Geraldo deThis study aimed to investigate the potential of an oral formulation (QV formulation) containing Quercetin and a Dipeptidyl Peptidase-4 Inhibitor (DPP-4 inhibitor), Vildagliptin, in improving metabolic homeostasis in type 1 diabetes model. Female albino Fischer rats were divided into four groups: untreated control animals (C), untreated diabetic animals (D), diabetic animals treated with QV formulation (DQV), a...
The antioxidant and anti-inflammatory properties of lycopene in mice lungs expo...
Campos, Keila Karine Duarte; Araújo, Glaucy Rodrigues de; Martins, Thais Lourenço; Bandeira, Ana Carla Balthar; Costa, Guilherme de PaulaLycopene is a carotenoid with knownantioxidant and anti-inflammatory properties.Weaimed to evaluate the in vitro and in vivo effects of lycopene on reducing the redox imbalance and inflammation induced by cigarette smoke (CS). For the in vitro study, J774A.1 (macrophages) cells were incubated in the presence of 0.5, 1.0, 2.0, 4.0, 8.0, 10.0 and 25 μMof lycopene for 3, 6 and 24 h or in the presence of 0.1%, 0.25...
Lycopene pretreatment improves hepatotoxicity induced by acetaminophen in C57BL...
Bandeira, Ana Carla Balthar; Silva, Rafaella Cecília da; Rossoni Júnior, Joamyr Victor; Figueiredo, Vivian Paulino; Silva, André Talvani Pedrosa daAcetaminophen (APAP) is an antipyretic and analgesic drug that, in high doses, leads to severe liver injury and potentially death. Oxidative stress is an important event in APAP overdose. Researchers are looking for natural antioxidants with the potential to mitigate the harmful effects of reactive oxygen species in different models. Lycopene has been widely studied for its antioxidant properties. The aim of th...
Increased α1-adrenoreceptor activity is required to sustain blood pressure in f...
Souza, Aline Maria Arlindo de; Menezes, Rodrigo Cunha Alvim de; Abreu, Aline Rezende Ribeiro de; Araujo, Glaucy Rodrigues de; Costa, Daniela CaldeiraAims: Weevaluated the effect of food restriction (FR) on the various reflexes involved in short termcardiovascular regulation; we also evaluated the contribution of the sympathetic nervous systemand of the plasmatic nitric oxide (NO) in the development of the counterregulatory cardiovascular changes triggered by FR. Main methods: Female rats were subjected to FR for 14 days, and after this period biochemical me...