6 documents found, page 1 of 1
Clostridioides difficile Toxin A-Induced Wnt/β-Catenin Pathway Inhibition Is Me...
Martins, Conceição S.; Costa, Deiziane V. S.; Lima, Bruno B.; Leitäo, Renata Ferreira de Carvalho; Freire, Gildênio E.; Silva, Guilherme F. M.Clostridioides difficile toxin A (TcdA) has been shown to inhibit cellular Wnt signaling, the major driving force behind the proliferation of epithelial cells in colonic crypts, likely through the inhibition of β-catenin nuclear translocation. Herein, we aimed to advance the understanding of this mechanism by replicating the findings in vivo and by investigating the specific role of Rac1, a member of the Rho GT...
The alpha-lipoic acid improves survival and prevents irinotecan-induced inflamm...
Costa, Daniely V. S.; Costa, Deiziane V. S.; Sousa, Caren N. S.; Silva, Angeline M. H. P.; Medeiros, Ingridy S.; Martins, Dainesy S.Irinotecan, an anticancer drug, induces diarrhea and intestinal inflammation, resulting in an increase in the cost of care and in treatment delays. In this study, we investigated whether alpha-lipoic acid (α-LA) could improve irinotecan-mediated intestinal inflammation, diarrhea and dysmotility. Intestinal mucositis was induced by irinotecan injection (75 mg/kg, i.p., for 4 days) in Swiss mice. α-LA (50, 100 or...
Enteropathogenic Escherichia coli Infection Induces Diarrhea, Intestinal Damage...
Ledwaba, Solanka E.; Costa, Deiziane V. S.; Bolick, David T.; Giallourou, Natasa; Medeiros, Pedro H. Q. S.; Swann, Jonathan R.; Traore, Afsatou N.Enteropathogenic E. coli (EPEC) are recognized as one of the leading bacterial causes of infantile diarrhea worldwide. Weaned C57BL/6 mice pretreated with antibiotics were challenged orally with wild-type EPEC or escN mutant (lacking type 3 secretion system) to determine colonization, inflammatory responses and clinical outcomes during infection. Antibiotic disruption of intestinal microbiota enabled efficient ...
5-Fluorouracil induces enteric neuron death and glial activation during intesti...
Costa, Deiziane V. S.; Bon-Frauches, Ana C.; Silva, Angeline M. H. P.; Lima-Júnior, Roberto C. P.; Martins, Conceição S.5-Fluorouracil (5-FU) is an anticancer agent whose main side effects include intestinal mucositis associated with intestinal motility alterations maybe due to an effect on the enteric nervous system (ENS), but the underlying mechanism remains unclear. In this report, we used an animal model to investigate the participation of the S100B/RAGE/NFκB pathway in intestinal mucositis and enteric neurotoxicity caused b...
The involvement of mast cells in the irinotecan-induced enteric neurons loss an...
Nogueira, Ludmila T.; Costa, Deiziane V. S.; Gomes, Antoniella Souza; Martins, Conceição S.; Silva, Angeline M. H. P.; Coelho-Aguiar, Juliana M.Background The irinotecan (CPT-11) causes intestinal mucositis and diarrhea that may be related to changes in the enteric nervous system (ENS). In inflammatory condition, mast cells release a variety of pro-inflammatory mediators that can interact with the ENS cells. It has not been explored whether CPT-11 is able to alter the enteric glial and neuronal cell, and the role of mast cells in this effect. Therefore...
Topical HPMC/S-nitrosoglutathione solution decreases inflammation and bone reso...
Martins, Conceição S.; Leitão, Renata Ferreira de Carvalho; Melo, Iracema M.; Santos, Glaylton S. Santo; Baldim, Victor Baldim; Bonfim, Luana E.S-nitrosoglutathione (GSNO) is a nitric oxide (NO) donor, which exerts antioxidant, anti-inflammatory, and microbicidal actions. Intragingival application of GSNO was already shown to decrease alveolar bone loss, inflammation and oxidative stress in an experimental periodontal disease (EPD) model. In the present study, we evaluated the potential therapeutic effect of topical applications of hydroxypropylmethylc...