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From waste to wellness: sardine by-products as rich sources of bioactive ingred...

Machado, Manuela; Costa, Eduardo; Augusto, Helga; Cação, Ana; Pintado, Manuela E.

The sustainable utilization of sardine by-products represents a valuable contribution to addressing global challenges in waste management and health nutrition. Sardine byproducts, typically discarded or utilized as low-value inputs in animal feed and fertilizer, have demonstrated potential as a source of bioactive ingredients. This study highlights the composition and bioactive properties of sardine protein hyd...


Gold nanoparticles: a promising next-generation tool for breast cancer photothe...

Ferreira-Gonçalves, Tânia; Costa, Eduardo; Coelho, João; Gaspar, Maria Manuela; Ascensão, Lia; Ferreira-Santos, Pedro; Faísca, Pedro; Figueiredo, Isabel

AuNPs show suitable mean sizes and maximum absorbance peaks to be used for PTT when locally administered. AuNPs show no toxicity either in breast cancer cell lines or red blood cells. Laser irradiation proved to be safe when applied alone. Combining EGF-conjugated AuNPs with laser irradiation resulted in a reduction of 33% in MCF-7 cells viability. The animal model was successfully developed (all animals develo...


Integrated Care for Kidney Disease in Portugal: Barriers to Access to Therapeut...

Aranda da Silva, José; Ferreira, Aníbal; Costa, Eduardo; Rodrigues, Anabela; Almeida, Edgar; Calixto, Liliana; Dinis, Paulo; Henriques, António

A Reunião de Reflexão, realizada a 4 de julho de 2025, teve como principal objetivo a análise crítica do atual modelo de prestação de cuidados a doentes com doença renal crónica (DRC) em Portugal, com especial enfoque no acesso à inovação terapêutica e equidade na prestação de cuidados. Pretendeu-se reunir um conjunto alargado de perspetivas técnicas e clínicas que pudessem contribuir para a identificação de po...


Alkaline extraction of phenolic compounds from Eucalyptus leaves: influence on ...

Afonso, Tiago Barros; Bonifácio-Lopes, Teresa; Costa, Eduardo; Macedo, Tiago; Moreira, Joana; Oliveira, Juliana; Pintado, Manuela

Background: The valorization of agro-industrial by-products is a strategic approach to reducing biomass waste while advancing circular bioeconomy practices. Eucalyptus leaves, an abundant residue from the forestry and pulp industries, are particularly rich in phenolic compounds with well- known antioxidant and antimicrobial activities. These bioactivities highlight the potential of eucalyptus extracts for susta...


From waste to worth: upcycling peanut skin via green extraction for bioactive a...

Afonso, Tiago B.; Bonifácio-Lopes, Teresa; Costa, Eduardo; Costa, Ana Filipa; Oliveira, Juliana A. S. A.; Pintado, Manuela E.

Aim: The valorisation of agro-industrial by-products represents a strategic approach toward reducing food processing waste while fostering circular bioeconomy practices. Peanut skin, a by-product of peanut processing, is particularly rich in phenolic compounds with significant antioxidant and antimicrobial properties, making it a promising candidate for sustainable applications in the cosmetic and textile indus...


Alkaline extraction of phenolic compounds from Eucalyptus leaves: influence on ...

Afonso, Tiago B.; Bonifácio-Lopes, Teresa; Costa, Eduardo; Macedo, Tiago; Moreira, Joana; Oliveira, Juliana; Pintado, Manuela

Introduction: The valorization of agro-industrial by-products is a strategic approach to reducing biomass waste while advancing circular bioeconomy practices. Eucalyptus leaves, an abundant residue from the forestry and pulp industries, are particularly rich in phenolic compounds with well-known antioxidant and antimicrobial activities. These bioactivities highlight the potential of eucalyptus extracts for sust...


Strategies to reduce the burden of respiratory syncytial virus infections in ch...

Ferreira-Magalhães, Manuel; Bandeira, Teresa; Costa, Eduardo; Guerra, Paula; Lopes, Hugo; Martins, Maria Rosário; Mexia, Ricardo; Tomé, Teresa


SE-HPLC as a tool to guide the production of novel peptide fractions for textil...

Bonifácio-Lopes, Teresa; Afonso, Tiago Barros; Coscueta, Ezequiel; Costa, Eduardo; Pintado, Manuela

As the need for more bio centered solutions within the textile industry, complex increases it has been the role of R&D industries and academia to find within themselves tools that can guide the discovery and development of biobased products and solutions. One technique that nowadays plays a key role in the sustainable development of novel textile solutions is Size Exclusion HPLC (SE-HPLC). While on its core SE-...


A circular economy approach to leather by products valorization towards a zero-...

Bonifácio-Lopes, Teresa; Afonso, Tiago Barros; Coscueta, Ezequiel; Costa, Eduardo; Pintado, Manuela

The tanning industry, known for its significant waste production, has a great environmental footprint and is one of the main contributors of environmental pollution. To address this concern, this industry has been actively adopting circular economy principles to repurpose the by-products it generates. One of its key focuses is the reutilization of leather by-products, aiming to minimize environmental harm throu...


Integrated valorization of fucus spiralis alga: polysaccharides and bioactives ...

Martins, Valter F. R.; Coelho, Marta; Machado, Manuela; Costa, Eduardo; Gomes, Ana M.; Poças, Fátima; Sperotto, Raul A.; Rosa-Martínez, Elena

Fucus spp. seaweeds thrive in the cold temperate waters of the northern hemisphere, specifically in the littoral and sublittoral regions along rocky shorelines. Moreover, they are known to be a rich source of bioactive compounds. This study explored the valorization of Fucus spiralis through the extraction of bioactives and polysaccharides (PSs) for food applications and biostimulant use. The bioactives were ex...


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