75 documents found, page 1 of 8
Exploring the effects of sweet potato leaves on skin health - from antimicrobia...
Machado, Manuela; Silva, Sara; Pintado, Manuela; Costa, Eduardo M.Sweet potato leaves (SPL), an agricultural byproduct, hold significant potential in dermatological applications due to their bioactive compounds. This study evaluates the phenolic profile of SPL extracts and investigates their biological activities relevant to skin health. Extract fingerprinting, through uHPLC-DAD and LC–MS, identified phenolic acids and flavonoids, with cynarin, neochlorogenic acid, and spirae...
Bioactive food proteins: bridging nutritional and functional benefits with sust...
Machado, Manuela; Bautista-Hérnandez, Israel; Gómez-García, Ricardo; Silva, Sara; Costa, Eduardo M.Bioactive food proteins play multifunctional roles in human health and functional food development. Beyond their nutritional value, these proteins contain peptide sequences capable of exerting physiological effects, such as antioxidant, anti-hypertensive, immunomodulatory, and anti-inflammatory activities. This review summarises the processing and functional technologies applied to bioactive proteins; the incre...
Biodegradable films with polysaccharides, proteins, and bioactive compounds fro...
Martins, Valter F. R.; Lopes, Ana I.; Machado, Manuela; Costa, Eduardo M.; Ribeiro, Tânia B.; Poças, Fátima; Pintado, Manuela; Morais, Rui M. S. C.Microalgae are a sustainable source of bioactive compounds and nutrients that do not compete with crops for arable land. Lobosphaera sp. was used to produce biodegradable films. Bioactive compounds, polysaccharides, and proteins were extracted from this microalga. The total phenolic content (TPC) and antioxidant activity (ABTS, DPPH, and ORAC) of the bioactive-rich extract were determined, and its composition w...
Valorization of Solanum melongena L. crop by-products: phenolic composition and...
Añibarro-Ortega, Mikel; Dias, Maria Inês; Petrović, Jovana; Núñez, Sonia; Calhelha, Ricardo C.; Costa, Eduardo M.; Machado, M.; Pintado, ManuelaThis study explored the valorization of post-harvest eggplant aerial parts as a sustainable source of value-added ingredients by investigating their phenolic composition and in vitro bioactive properties. HPLC-DAD-ESI/MSn analysis identified chlorogenic acid derivatives as the predominant phenolic compounds (53 % of the phenolic fraction), followed by O-glycosylated kaempferol and quercetin. The extract display...
Precision fermentation as a tool for sustainable cosmetic ingredient production
Silva, Sara; Bautista-Hérnandez, Israel; Gomez-García, Ricardo; Costa, Eduardo M.; Machado, ManuelaPrecision fermentation, a highly controlled process of microbial fermentation, is emerging as a transformative tool to produce cosmetic ingredients. This technology leverages engineered micro-organisms to produce high-value compounds with applications in skincare, hair care, and other cosmetic formulations. Unlike traditional methods of ingredient sourcing, which often rely on extraction from plants or animals,...
Evaluating pomegranate seed oil for potential topical applications: safety, ant...
Costa, Eduardo M.; Machado, Manuela; Pintado, Manuela; Silva, SaraPomegranate seed oil (PSO), a by-product of pomegranate juice production, has a long-standing role in traditional medicine, yet is mechanistic and pharmaceutical potential for skin applications remains unexplored. This work explored the bioactivity of PSO in human keratinocytes (HaCaT) and dermal fibroblasts (HDFa) through evaluation of its impact upon cellular metabolism, anti-inflammatory properties and wound...
Fortification of yogurt with Solanum melongena phenolic extract: physicochemica...
Añibarro-Ortega, Mikel; Gómez-García, Ricardo; Machado, Manuela; Pereira, Alexis; Costa, Eduardo M.; Pintado, Manuela; Barros, Lillian; Pinela, JoséThis study investigated the impact of fortifying yogurt with Solanum melongena phenolic extract by assessing its physicochemical, biochemical, and antioxidant stability, including its behavior during in vitro simulated digestion. Fortification influenced the yogurt's pH, titratable acidity, and color, and improved its cohesiveness during shelf life. The fortified yogurt exhibited higher glucose levels and reduc...
Fortification of yogurt with Solanum melongena phenolic extract: Physicochemica...
Añibarro-Ortega, Mikel; Gómez-García, Ricardo; Machado, Manuela; Pereira, Alexis; Costa, Eduardo M.; Pintado, Manuela; Barros, Lillian; Pinela, JoséThis study investigated the impact of fortifying yogurt with Solanum melongena phenolic extract by assessing its physicochemical, biochemical, and antioxidant stability, including its behavior during in vitro simulated digestion. Fortification influenced the yogurt's pH, titratable acidity, and color, and improved its cohesiveness during shelf life. The fortified yogurt exhibited higher glucose levels and reduc...
Bioactive aromatic plant extracts modulate metabolism and inflammation in HeLa ...
Silva, Sara; Machado, Manuela; Pintado, Manuela; Costa, Eduardo M.Aromatic plants are rich sources of bioactive compounds with recognized therapeutic potential. This study investigated the phytochemical composition and biological activities of ethanolic extracts from four aromatic species—Thymus vulgaris L. (thyme), Rosmarinus officinalis L. (rosemary), Aloysia citrodora (lemon verbena), and Tanacetum balsamita L. (costmary)—using HeLa human cancer cells as a model. LC–MS ana...
Exploring the health benefits of lentil phenolics: antioxidant and immunomodula...
Geraldo, Rafaela A. F.; Machado, Manuela; Silva, Sara; Costa, Eduardo M.; Pinto, Elisabete; Pintado, Manuela; Neves, Delminda; Vasconcelos, Marta W.Introduction: Lentils are rich in essential nutrients such as protein, fibre, and flavonoids, with a low glycemic index that helps avoid glycemia peaks. Epidemiological data suggest potential benefits against cardiovascular diseases and diabetes. Objectives: Identify the lentil variety with the highest phenolic and flavonoid content, antioxidant capacity, and anti-diabetic effects while evaluating its cytotoxic...