5 documents found, page 1 of 1
Th17/Treg imbalance in murine cystic fibrosis is linked to indoleamine 2,3-diox...
Iannitti, Rossana G.; Carvalho, Agostinho; Cunha, Cristina; De Luca, Antonella; Giovannini, Gloria; Casagrande, Andrea; Zelante, Teresa; Vacca, CarmineRationale: Mutations in the cystic fibrosis (CF) transmembrane conductance regulator affect the innate epithelial immune function of the lung, resulting in exaggerated and ineffective airway inflammation that fails to eradicate pathogenic fungi. The appreciation of whether such fungi are primarily responsible for or a consequence of ineffective airway inflammation is important for future therapeutics developmen...
Dectin-1 isoforms contribute to distinct Th1/Th17 cell activation in mucosal ca...
Carvalho, Agostinho; Giovannini, Gloria; De Luca, Antonella; D’Angelo, Carmen; Casagrande, Andrea; Iannitti, Rossana G.; Ricci, GiovanniRecognition of β-glucans by dectin-1 has been shown to mediate cell activation, cytokine production and a variety of antifungal responses. Here, we report that the functional activity of dectin-1 in mucosal immunity to Candida albicans is influenced by the genetic background of the host. Dectin-1 was required for the proper control of gastrointestinal and vaginal candidiasis in C57BL/6 but not BALB/c mice, the ...
From memory to antifungal vaccine design
Iannitti, Rossana G.; Carvalho, Agostinho; Romani, LuiginaFungal infections and related diseases have a high morbidity and mortality rate. Human antifungal vaccines are therefore of great interest, however, their development is challenging. Major hurdles include fungal species-specific differences in pathogenic mechanisms and strategies to escape immune surveillance, as well as the fact that individuals susceptible to infection do not necessarily share the same risk f...
CD4+ T cell vaccination overcomes defective cross-presentation of fungal antige...
Luca, Antonella De; Iannitti, Rossana G.; Bozza, Silvia; Beau, Remi; Casagrande, Andrea; D’Angelo, Carmen; Moretti, Silvia; Cunha, CristinaAspergillus fumigatus is a model fungal pathogen and a common cause of infection in individuals with the primary immunodeficiency chronic granulomatous disease (CGD). Although primarily considered a deficiency of innate immunity, CGD is also linked to dysfunctional T cell reactivity. Both CD4+ and CD8+ T cells mediate vaccine-induced protection from experimental aspergillosis, but the molecular mechanisms leadi...
TLR3 essentially promotes protective class I–restricted memory CD8+ T-cell resp...
Carvalho, Agostinho; De Luca, Antonella; Bozza, Silvia; Cunha, Cristina; D’Angelo, Carmen; Moretti, Silvia; Perruccio, Katia; Iannitti, Rossana G.Aspergillus fumigatus is a model fungal pathogen and a common cause of severe infections and diseases. CD8+ T cells are present in the human and murine T-cell repertoire to the fungus. However, CD8+ T-cell function in infection and the molecular mechanisms that control their priming and differentiation into effector and memory cells in vivo remain elusive. In the present study, we report that both CD4+ and CD8+...