8 documents found, page 1 of 1
Association of genetic variants rs641153 (CFB), rs2230199 (C3), and rs1410996 (...
Miguel Neto, Jamil, 1988-; Viturino, Marina Gonçalves Monteiro, 1990-; Ananina, Galina, 1961-; Bajano, Flávia FialhoAgradecimentos: This study was supported by the Fund for Support to Teaching, Research and Outreach Activities (FAEPEX) grants 1525/15 and 251/18 and by S~ao Paulo Research Foundation (FAPESP) grant 2010/18353–9; Abstract: This study aimed to investigate the association among genetic variants of the complement pathway CFB R32Q (rs641153), C3 R102G (rs2230199), and CFH (rs1410996) with age-related macular degene...
Evaluation of APOE polymorphisms and the risk for age-related macular degenerat...
Viturino, Marina Gonçalves Monteiro, 1990-; Miguel Neto, Jamil, 1988-; Bajano, Flávia Fialho; Silva-Costa, Sueli Matilde da, 1962-Agradecimentos: The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This study was supported by the Fund for Support to Teaching, Research and Outreach Activities (FAEPEX) grants 1525/15 and 251/18 and by S~ao Paulo Research Foundation (FAPESP) grant 2010/18353–9; Abstract: This study aimed to evaluate the role of APOE polymorphism...
"Association of APOE gene polymorphisms with primary open angle glaucoma in Bra...
Occhiutto, Marcelo Luís, 1966-; Melo, Mônica Barbosa de, 1968-; Vasconcellos, José Paulo Cabral de, 1963-; Rodrigues, Thiago Adalton Rosa, 1997Agradecimentos: São Paulo Research Foundation, FAPESP (grant 2010/18353-9); Abstract: Background: Primary open-angle glaucoma (POAG) is a multifactorial disease that affects 65.5 million people worldwide. In addition to the genetic variants already established as indicators of greater risk for POAG, the apolipoprotein (APOE) gene has been studied in some populations, with controversial results. The aim of this ...
Different morphological and gene expression profile in placentas of the same si...
Baptista, Letícia de Carvalho, 1990-; Figueira, Camilla Olivares, 1982-; Souza, Bruno Batista, 1983-; Tavares, Arthur AntoliniAgradecimentos: This study was supported by São Paulo Research Foundation (FAPESP) grant 2015/08330-5, grant 2014/00984-3 and the National Council for Scientific and Technological Development (CNPq) grant 409605/2016-6; Abstract: Environmentally induced changes in placental morphological and molecular phenotypes may provide relevant insight towards pathophysiology of diseases. Sickle cell disease (SCD) is a com...
Sickle cell/ß-thalassemia : comparison of Sß0 and Sß+ brazilian patients follow...
Benites, Bruno Deltreggia, 1984-; Ramos, Celso Darío, 1964-; Costa, Fernando Ferreira, 1950-; Gilli, Simone Cristina OlensckiAbstract: In sickle cell/ß-thalassemia, mutations in the corresponding ß-globin genes are responsible for complex pathological events resulting in diverse clinical complications. The objective of this study was to provide an overview of the clinical and laboratory characteristics of patients with the syndrome, and of the degree of severity of clinical manifestations resulting from the ß-thalassemia mutation. A ...
Increased circulating PEDF and low sICAM-1 are associated with sickle cell reti...
Cruz, Pedro Rodrigues Sousa da, 1987-; Lira, Rodrigo Pessoa Cavalcanti, 1973-; Souza, Bruno Batista, 1983-; Fertrin, Kleber Yotsumoto, 1980-Agradecimentos: We would like to thank Fundacao de Amparo a Pesquisa do Estado de Sao Paulo-FAPESP (grants #2009/15219-2 and #2008/57441-0) and Conselho Nacional para o Desenvolvimento Cientifico e Tecnologico-CNPq (grant #402022/2010-6) for-financial support; Abstract: Sickle cell retinopathy (SCR) develops in up to 30% of sickle cell disease patients (SCD) during the second decade of life. Treatment for this ...
In vitro and in vivo anti-angiogenic effects of hydroxyurea
Ferreira, Regiane Aparecida, 1983-; Albuquerque, Dulcinéia Martins de; Silveira, Angélica Aparecida Antoniellis, 1987-; Costa, Fernando Ferreira, 1950-Agradecimentos: The authors would like to thank Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) for funding this study (grants 2009/16334-0 [FCMFCML's fellowship], 08/57441-0), as well as CNPq-Brazil (Grant 565036/2010) and FCT (Pest-OE/SAU/UI0038/2011; Portugal). We also thank Cristina P. Vicente for help with microscopy; Abstract: Hydroxyurea (HU), or hydroxycarbamide, is used for the treatment ...
The CCR5'delta'32 polymorphism in brazilian patients with sickle cell disease
Santos, Magnun Nueldo Nunes dos, 1984-; Zaccariotto, Tania Regina; Ribeiro, Daniela Maria; Costa, Fernando Ferreira, 1950-Agradecimentos: This work was supported by the State of São Paulo Research Foundation (FAPESP) (Grant nos. 2008/57441-0 and 2011/02622-3), the National Council for Scientific and Technological Development (CNPq) (Grant no. 472127/2007-1), and the Agency for the Support and Evaluation of Graduate Education (CAPES) (Brazil). The authors thank Mrs. C. A. M. Silva of the Statistical Advice Service, School of Medica...