27 documents found, page 1 of 3
Perioperative Ultrasound-Guided Continuous Caudal Epidural Analgesia in Newborn...
Portela, F; Costa, G; Cenicante, TBackground Caudal epidural anesthesia technique is a relevant method for postoperative analgesia in newborns, allowing for the reduction of drug-induced respiratory depression. The threading of a catheter is, however, uncommon in clinical practice. Our main purpose was to describe our experience regarding caudally inserted epidural catheters in neonates undergoing major abdominal surgery. Methods We included ev...
A fundamental distinction in early neural processing of implicit social interpr...
Madeira, N; Martins, R; Valente Duarte, J; Costa, G; Macedo, A; Castelo-Branco, MBackground: Social cognition impairment is a key phenomenon in serious mental disorders such as schizophrenia (SCZ) and bipolar disorder (BPD). Although genetic and neurobiological studies have suggested common neural correlates, here we hypothesized that a fundamental dissociation of social processing occurs at an early level in these conditions. Methods: Based on the hypothesis that key structures in the soci...
Kinetics of radium-223 and its effects on survival, proliferation and DNA damag...
Marques, IA; Abrantes, AM; Pires, AS; Neves, AR; Caramelo, FJ; Rodrigues, T; Matafome, P; Tavares-da-Silva, E; Gonçalves, AC; Pereira, CC; Teixeira, JPBackground Metastatic castration-resistant prostate cancer (mCRPC) is associated with a very unfavorable prognosis. At this advanced stage of the disease, there are several therapeutic strategies approved in recent times, being one of them Radium-223 dichloride (Radium-223). However, its mechanisms of action and the process that conducts to cell death are not fully understood. Given this, our main goal is to ch...
Special Report: The Biology of Inequalities in Health: The Lifepath Consortium
Vineis, P; Avendano-Pabon, M; Barros, H; Bartley, M; Carmeli, C; Carra, L; Chadeau-Hyam, M; Costa, G; Delpierre, C; D'Errico, A; Fraga, S; Giles, GFunded by the European Commission Horizon 2020 programme, the Lifepath research consortium aimed to investigate the effects of socioeconomic inequalities on the biology of healthy aging. The main research questions included the impact of inequalities on health, the role of behavioral and other risk factors, the underlying biological mechanisms, the efficacy of selected policies, and the general implications of ...
Interplay between sympathetic nervous system and inflammation in aseptic loosen...
Ribeiro da Silva, M.; Vasconcelos, DM; Alencastre, IS; Oliveira, MJ; Linhares, D; Neves, N; Costa, G; Henrique, R; Lamghari, M; Alves, CJInflammation is a common symptom in joint disorders such as rheumatoid arthritis, osteoarthritis (OA) and implant aseptic loosening (AL). The sympathetic nervous system is well known to play a critical role in regulating inflammatory conditions, and imbalanced sympathetic activity has been observed in rheumatoid arthritis. In AL it is not clear whether the sympathetic nervous system is altered. In this study we...
Interplay between sympathetic nervous system and inflammation in aseptic loosen...
Ribeiro-da-Silva, M; Vasconcelos, DM; Alencastre, IS; Oliveira, MJ; Linhares, D; Neves, N; Costa, G; Henrique, R; Lamghari, M; Alves, CJInflammation is a common symptom in joint disorders such as rheumatoid arthritis, osteoarthritis (OA) and implant aseptic loosening (AL). The sympathetic nervous system is well known to play a critical role in regulating inflammatory conditions, and imbalanced sympathetic activity has been observed in rheumatoid arthritis. In AL it is not clear whether the sympathetic nervous system is altered. In this study we...
Socioeconomic status, non-communicable disease risk factors, and walking speed ...
Stringhini, S; Carmeli, C; Jokela, M; Avendaño, M; McCrory, C; d'Errico, A; Bochud, M; Barros, H; Costa, G; Chadeau-Hyam, M; Delpierre, C; Gandini, MObjective To assess the association of low socioeconomic status and risk factors for non-communicable diseases (diabetes, high alcohol intake, high blood pressure, obesity, physical inactivity, smoking) with loss of physical functioning at older ages. Design Multi-cohort population based study. Setting 37 cohort studies from 24 countries in Europe, the United States, Latin America, Africa, and Asia, 1990-2017 P...
Socioeconomic indicators in epidemiologic research: A practical example from th...
d'Erico, A; Ricceri, F; Stringhini, S; Carmeli, C; Kivimaki, M; Bartley, M; McCrory, C; Bochud, M; Vollenweider, P; Tumino, R; Goldberg, M; Zins, MBackground: Several social indicators have been used in epidemiological research to describe socioeconomic position (SEP) of people in societies. Among SEP indicators, those more frequently used are education, occupational class and income. Differences in the incidence of several health outcomes have been reported consistently, independently from the indicator employed. Main objectives of the study were to pres...
TERT, BRAF and NRAS in primary thyroid cancer and metastatic disease
Melo, M; Gaspar da Rocha, A; Batista, R; Vinagre, J; Martins, MJ; Costa, G; Ribeiro, C; Carilho, F; Leite, V; Lobo, C; Cameselle-Teijeiro, JMContext: Little is known about the frequency of key mutations in thyroid cancer metastases and its relationship with the primary tumor genotype. Objectives: To evaluate the frequency of TERT promoter (TERTp), BRAF, and NRAS mutations in metastatic thyroid carcinomas, analyzing primary thyroid tumors, lymph node metastases (LNMs), and distant metastases. Design and Patients: Mutation analysis was performed in 43...
Socioeconomic status and the 25 × 25 risk factors as determinants of premature ...
Stringhini, S; Carmeli, C; Jokela, M; Avendaño, M; Muennig, P; Guida, F; Ricceri, F; d'Errico, A; Barros, H; Bochud, M; Chadeau-Hyam, MBackground: In 2011, WHO member states signed up to the 25 × 25 initiative, a plan to cut mortality due to non-communicable diseases by 25% by 2025. However, socioeconomic factors influencing non-communicable diseases have not been included in the plan. In this study, we aimed to compare the contribution of socioeconomic status to mortality and years-of-life-lost with that of the 25 × 25 conventional risk facto...