15 documents found, page 1 of 2
The curcumin supplementation with piperine can influence the acute elevation of...
Miranda-Castro, Stéfani; Aidar, Felipe J.; Moura, Samara Silva de; Marcucci-Barbosa, Lucas; Lobo, Lázaro FernandesBackground: to evaluate the effects of one week of supplementation with curcumin combined with piperine on physical performance, immune system cell counts, muscle damage, and plasma levels of inflammatory markers after a treadmill running training session. Methods: This study is a double-blind, crossover-balanced clinical trial with a three-week intervention. Sixteen male runners with a mean age of 36 ± 9 years...
Exogenous surfactant prevents hyperoxiainduced lung injury in adult mice.
Bezerra, Frank Silva; Ramos, Camila de Oliveira; Castro, Thalles de Freitas; Araújo, Natália Pereira da Silva; Souza, Ana Beatriz Farias deBackground: In addition to the risk of developing ventilator-induced lung injury, patients with ARDS are at risk of developing hyperoxic injury due the supra-physiological oxygen supplementation clinically required to reverse hypoxemia. Alterations of endogenous surfactant system participate in the pulmonary dysfunction observed in ARDS. Administration of exogenous surfactant could have protective effects durin...
The β-blocker carvedilol and the benznidazole modulate the cardiac immune respo...
Horta, Aline Luciano; Figueiredo, Vivian Paulino; Leite, Ana Luísa Junqueira; Costa, Guilherme de Paula; Menezes, Ana Paula de JesusBACKGROUND The infection led by Trypanosoma cruzi persists in mammalian tissues causing an inflammatory imbalance. Carvedilol (Cv), a non-selective beta blocker drug indicated to treat heart failure and antihypertensive has shown to promote antioxidant and immunomodulatory properties which might improve the inflammation induced by T. cruzi. OBJECTIVES Evaluate the role of Cv on the inflammatory response of C57B...
Enalapril in combination with benznidazole reduces cardiac inflammation and cre...
Penitente, Arlete Rita; Leite, Ana Luísa Junqueira; Costa, Guilherme de Paula; Shrestha, Deena; Horta, Aline Luciano; Natali, Antônio J.The protozoan Trypanosoma cruzi triggers an inflammatory process in mammalian heart causing events such as fibrosis, changes in the architecture and functionality in this organ. Enalapril, an angiotensin II-converting enzyme inhibitor, is a drug prescribed to ameliorate this heart dysfunction, and appears to exert a potential role in immune system regulation. Our aim was to evaluate the chronic cardiac inflamma...
The administration of surfactant decreased oxidative stress in lungs of mice ex...
Machado, Dafne Fernandes; Campos, Keila Karine Duarte; Silva, Natália Pereira da; Ramos, Camila de Oliveira; Cangussú, Silvia DantasThe alveolar surfactant, which composition consists of a unique and complex mixture of lipids and proteins, has immunomodulatory action. This study aimed to evaluate the effects of exogenous surfactant on pulmonary inflammatory response in mice exposed to cigarette smoke (CS). Twenty-four mice C57BL/6 were divided into four groups: control group exposed to ambient air (CG); surfactant treated group (SG); CS exp...
High-Fat diet increases HMGB1 expression and promotes lung inflammation in mice...
Souza, Ana Beatriz Farias de; Chírico, Máira Tereza Talma; Cartelle, Christiane Teixeira; Costa, Guilherme de Paula; Silva, André Talvani Pedrosa daThis study aims to evaluate the effects of a high-fat diet and mechanical ventilation on the pulmonary and systemic inflammatory response in C57BL/6 mice. Male C57BL/6 mice were divided into two groups: one received a standard diet, and the other received a high-fat diet. After 10 weeks, the groups were further divided into two groups each: control group (CG), mechanical ventilation group (MVG), diet group (DG)...
CXCL-16, IL-17, and bone morphogenetic protein 2 (BMP-2) are associated with ov...
Ribeiro, Silvana Mara Luz Turbino; Lopes, Laís Roquete; Costa, Guilherme de Paula; Figueiredo, Vivian Paulino; Bajracharya, Deena ShresthaThe current concept of overweight/obesity is most likely related to a combination of increased caloric intake and decreased energy expenditure. Widespread inflammation, associated with both conditions, appears to contribute to the development of some obesity-related comorbidities. Interventions that directly or indirectly target individuals at high risk of developing obesity have been largely proposed because o...
Potential role of Carvedilol in the cardiac immune response induced by experime...
Horta, Aline Luciano; Leite, Ana Luísa Junqueira; Costa, Guilherme de Paula; Figueiredo, Vivian Paulino; Silva, André Talvani Pedrosa daTrypanosoma cruzi causes a cardiac infection characterized by an inflammatory imbalance that could become the inciting factor of the illness. To this end, we evaluated the role of carvedilol, a beta-blocker with potential immunomodulatory properties, on the immune response in C57BL/6 mice infected with VL-10 strain of T. cruzi in the acute phase. Animals ( = 40) were grouped: (i) not infected, (ii) infected, (i...
The exposure to formaldehyde causes renal dysfunction, inflammation and redox i...
Ramos, Camila de Oliveira; Nardeli, Clarissa Rodrigues; Campos, Keila Karine Duarte; Pena, Karina Braga; Machado, Dafne FernandesTwenty-eight Fischer male rats were divided into four groups: control group (CG), exposed to the ambient air, and groups exposed to formaldehyde (FA) at concentrations of 1% (FA1%), 5% (FA5%) and 10% (FA10%). Kidney function was assessed by dosage of uric acid, creatinine and urea. Morphometry was performed on the thickness of the lumen of Bowman's capsule and diameter of the lumen of the renal tubules. We eval...
Expression and production of cardiac angiogenic mediators depend on the Trypano...
Bajracharya, Deena Shrestha; Bajracharya, Bijay; Costa, Guilherme de Paula; Salles, Beatriz Cristina Silveira; Leite, Ana Luísa JunqueiraMammalian cardiac cells are important targets to the protozoan Trypanosoma cruzi. The inflammatory reaction in the host aims at eliminating this parasite, can lead to cell destruction, fibrosis and hypoxia. Local hypoxia iswelldefined stimulus to the production of angiogenesis mediators. Assuming that different genetic T. cruzi populations induce distinct inflammation and disease patterns, the current study aim...