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A bile acid protects against motor and cognitive deficits and reduces striatal ...
Keene, CD; Rodrigues, CMP; Eich, T; Linehan-Stieers, C; Abt, A; Kren, BT; Steer, CJ; Low, WCThere is currently no effective treatment for Huntington's disease (HD), a progressive, fatal, neurodegenerative disorder characterized by motor and cognitive deterioration. It is well established that HD is associated with perturbation of mitochondrial e
Date: 2001
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Origin: Repositório da Universidade de Lisboa
Tauroursodeoxycholic acid prevents apoptosis induced by the neurotoxin 3-nitrop...
Rodrigues, CMP; Keene, CD; Linehan-Stieers, C; Ma, X; Low, W; Steer, CJ
Date: 2000
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Origin: Repositório da Universidade de Lisboa
Tauroursodeoxycholic acid partially prevents apoptosis induced by 3-nitropropio...
Rodrigues, CMP; Linehan-Stieers, C; Keene, CD; Ma, XM; Kren, BT; Low, WC; Steer, CJUrsodeoxycholic acid (UDCA) has been shown to be a strong modulator of the apoptotic threshold in both hepatic and nonhepatic cells. 3-Nitropropionic acid (3-NP), an irreversible inhibitor of succinate dehydrogenase, appears to cause apoptotic neuronal ce
Date: 2000
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Origin: Repositório da Universidade de Lisboa