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Targeting p53 for Melanoma Treatment: Counteracting Tumour Proliferation, Disse...
Loureiro, Joana B.; Raimundo, Liliana; Calheiros, Juliana; Carvalho, Carla; Barcherini, Valentina; Lima, Nuno R.; Gomes, Célia; Almeida, Maria InêsMelanoma is the deadliest form of skin cancer, primarily due to its high metastatic propensity and therapeutic resistance in advanced stages. The frequent inactivation of the p53 tumour suppressor protein in melanomagenesis may predict promising outcomes for p53 activators in melanoma therapy. Herein, we aimed to investigate the antitumor potential of the p53-activating agent SLMP53-2 against melanoma. Two- and...
Targeting p53 for melanoma treatment: counteracting tumour proliferation, disse...
Loureiro, Joana B.; Raimundo, Liliana; Calheiros, Juliana; Carvalho, Carla; Barcherini, Valentina; Lima, Nuno R.; Gomes, Célia; Almeida, Maria InêsMelanoma is the deadliest form of skin cancer, primarily due to its high metastatic propensity and therapeutic resistance in advanced stages. The frequent inactivation of the p53 tumour suppressor protein in melanomagenesis may predict promising outcomes for p53 activators in melanoma therapy. Herein, we aimed to investigate the antitumor potential of the p53-activating agent SLMP53-2 against melanoma. Two- and...
The Influence of the Genetic and Immunologic Context in the Development of Colo...
Garcia, Diogo; Spaans, Louisa; Miranda, Sara; Gonçalves, Gilza; Reis, Joana; Costa, José Luís; Durães, Cecília; Carneiro, Fátima; Machado, José CarlosIntroduction: Overcoming immunosurveillance is a major step in the progression of many types of tumors. Several immune escape strategies have been identified, including immunoediting and the establishment of an immune suppressive microenvironment. The aim of the present study was to determine whether the hereditary or sporadic context has any influence in the relationship between immune surveillance and tumor d...
Genetic Heterogeneity in Colorectal Cancer and its Clinical Implications
Barranha, Rui; Costa, José Luís; Carneiro, Fátima; Machado, José CarlosDespite the recent advances in the development of complementary diagnostic exams and modern targeted therapies, colorectal cancer remains a major cause of morbidity and mortality worldwide. In this context, a lot of research has been conducted in the last years to find new markers of poor prognosis. The existence of a complex tumour architecture formed by multiple subclones genetically heterogeneous has been in...
Relatório Anual 2013 - A Situação do País em Matéria de Drogas e Toxicodependên...
Ribeiro, Carla; Guerreiro, Catarina; Bento, Anabela; Neto, Helena; Costa, José Luís; Dias, Lúcia; Mendes, Rosário; Castro, Mário; Andrade, Paula Vale deÉ responsabilidade do SICAD a elaboração deste Relatório, a apresentar anualmente à Assembleia da República e ao Governo Português, fornecendo elementos de apoio à decisão política e ao planeamento da intervenção. Anexo: O volume anexo ao Relatório integra informação mais pormenorizada relativa à componente do Relatório: Parte A - Caracterização e Evolução da Situação.