11 documents found, page 1 of 2

Shielding of actin by the endoplasmic reticulum impacts nuclear positioning

Nuclear position is central to cell polarization, and its disruption is associated with various pathologies. The nucleus is moved away from the leading edge of migrating cells through its connection to moving dorsal actin cables, and the absence of connections to immobile ventral stress fibers. It is unclear how these asymmetric nucleo-cytoskeleton connections are established. Here, using an in vitro wound assa...

Fighting S. aureus catheter-related infections with sophorolipids: electing an ...

Staphylococcus aureus medical devices related-infections, such as blood stream catheter are of major concern. Their prevention is compulsory and strategies, not prone to the development of resistance, to prevent S. aureus biofilms on catheter surfaces (e.g. silicone) are needed. In this work two different approaches using sophorolipids were studied to prevent S. aureus biofilm formation on medical grade silicon...

Fighting S. aureus catheter-related infections with sophorolipids: Electing an ...

Staphylococcus aureus medical devices related-infections, such as blood stream catheter are of major concern. Their prevention is compulsory and strategies, not prone to the development of resistance, to prevent S. aureus biofilms on catheter surfaces (e.g. silicone) are needed. In this work two different approaches using sophorolipids were studied to prevent S. aureus biofilm formation on medical grade silicon...

Oxidative injury in V79 Chinese hamster cells: protective

Oxidative cell injury could be induced by different reactive oxygen species (ROS) operating in multiple pathways. The present work is focused on three different models of oxidative stress: the xanthine/xanthine oxidase system (XXO), an extracellular superoxide anion generator; tert-butylhydroperoxide (TBHP), an analogue of lipid hydroperoxides; and doxorubicin (Dox), an anticancer drug. Superoxide and peroxyl r...

Kinetic study of dissociation of a copper(II) complex of a 14-membered tetraaza...

The kinetics of acid-catalyzed dissociation of the copper(II) complex with 7-methyl-3,7,11,17-tetraazabicyclo[11.3.1] heptadeca-1(17), 13,15-triene-3,11-diacetic acid (ac(2)Me[14] pyN(4)) at [H+] = 0.05-0.25 mol l(-1), I = 0.25 mol l(-1) (Na, H) ClO4, and T = 298.16 K was studied with conventional and stopped-flow UV/VIS spectroscopy. Three steps of consecutive complex reaction were observed. The very fast firs...

Evaluation of the protective effect of MnTMPyP on the cytotoxicity induced by d...

Macrocyclic copper(II) complexes

Synthetic superoxide dismutase mimetics have emerged as a potential novel class of drugs for the treatment of oxidative stress related diseases. Among these agents, metal complexes with macrocyclic ligands constitute an important group. In this work we synthesized five macrocyclic copper(II) complexes and evaluated their ability to scavenge the superoxide anions generated by the xanthine-xanthine oxidase system...

Pyridine-containing macrocyclic copper(II) complexes

Properties of a new 4-imidazolyl derivative of a 14-membered tetraazamacrocycli...

A new bis-N,N'-(5-methylimidazol-4-ylmethyl) derivative of a 14-membered tetraazamacrocycle, L-1, has been synthesized. The protonation constants of this compound and the stability constants of its complexes with divalent first-row transition metal ions and Fe3+ were determined at 298.2 K in aqueous 0.10 mol dm(-3) KNO3. Compound L-1 exhibits high overall basicity, which is mainly conferred by theimidazolyl gro...

Novel copper(II) macrocyclic complexes with superoxide scavenging activity