63 documents found, page 1 of 7

Evaluating the range expansion of recreational non-native fishes in Portuguese ...

Updating information on the distribution of recently introduced and other poorly known non-natives is essential to prevent and control their spread and better address biological invasions. Here, we combine scientific and citizen science data to update the distribution of five recently arrived (i.e., < 25 years), non-native fish species (Alburnus alburnus, Ameiurus melas, Rutilus rutilus, Sander lucioperca and S...

Retinoic acid (all-trans) presents antioxidant properties within human ovary an...

Both vitamin A and E support female reproduction and embryonic development. These vitamins have been associated with decreased fertility or failure to end the pregnancy in animals. An observational study was conducted on follicular fluid (FF) samples to determine the concentrations of fat-soluble vitamins of women undergoing in vitro fertilization and its correlation with assisted reproductive technology charac...

Human Microbiota and Breast Cancer—Is There Any Relevant Link?—A Literature Rev...

Human Microbiota and Breast Cancer—Is There Any Relevant Link?—A Literature Rev...

Breast cancer (BC) is the most common malignancy and the second cause of cancer-specific death in women from high-income countries. Recently, gut microbiota dysbiosis emerged as a key player that may directly and/or indirectly influence development, treatment, and prognosis of BC through diverse biological processes: host cell proliferation and death, immune system function, chronic inflammation, oncogenic sign...

Intraocular Lens Power Calculation Formulas Accuracy in Combined Phacovitrectom...

Background: Our study aimed to assess and compare the accuracy of 8 intraocular lens (IOL) power calculation formulas (Barrett Universal II, EVO 2.0, Haigis, Hoffer Q, Holladay 1, Kane and PEARL-DGS) in patients submitted to combined phacovitrectomy for vitreomacular (VM) interface disorders. Methods: Retrospective chart review study including axial-length matched patients submitted to phacoemulsification alone...

Concentrations of the endocannabinoid N-arachidonoylethanolamine in the follicu...

Although N-arachidonoylethanolamine (AEA; also known as anandamide) is present in human follicular fluid (FF), its regulation remains unknown. Therefore, the aims of the present study were to: (1) investigate the relationships between FF AEA concentrations in women undergoing assisted reproductive technology and their age, body mass index, ART characteristics and fertility treatment outcomes; and (2) assess how...

Aggressive neuroblastoma in a pediatric patient with severe hemophilia A

Despite the extensive information regarding hemophilia's hemorrhagic complications, the literature on cancer in hemophilia is scarce, especially in pediatric patients. Many uncertainties remain concerning diagnosis and workup. We report a rare case of two severe diseases (neuroblastoma and hemophilia A (HA)) concomitantly present in the same pediatric patient. We highlight that the diagnosis of severe HA did no...

Biocompatibility of the biopolymer cyanoflan for applications in skin wound hea...

There is a great demand for the development of novel wound dressings to overcome the time and costs of wound care performed by a vast number of clinicians, especially in the current overburdened healthcare systems. In this study, Cyanoflan, a biopolymer secreted by a marine unicellular cyanobacterium, was evaluated as a potential biomaterial for wound healing. Cyanoflan effects on cell viability, apoptosis, and...

Solving Multiobjective Engineering Design Problems Through a Scalarized Augment...

In this paper, a set of multiobjective engineering design problems is solved using a methodology that combines an Augmented Lagrangian technique to deal with the constraints and the Augmented Weighted Tchebycheff method to tackle the multiobjective nature of the problems to find the Pareto frontier. In order to compare and validate the performance of this strategy, the problems were also solved with gamultiobj ...

Real-world data from the Portuguese Nivolumab Expanded Access Program (EAP) in ...

OBJECTIVE: The main aim of the study was to evaluate the efficacy and safety profile of Nivolumab, an immune-checkpoint-inhibitor antibody, in advanced, previously treated, Non-Small Cell Lung Cancer (NSCLC) patients, in a real world setting. METHODS: We performed a retrospective, multicentre data analysis of patients who were included in the Portuguese Nivolumab Expanded Access Program (EAP). Eligibility crite...