The microstructural organization of bacterial nanocellulose is still not completely understood. Although its morphological and mechanical anisotropy is commonly recognized, it remains unclear whether the forces stabilizing the cellulose fiber network are comparable in different planes. In this study, we characterized the microstructure of statically produced BNC according to its horizontal and vertical planes. ...
The interfacial topography of biomaterials has been identified as a major biophysical regulator of cell behavior and function, a role played through the interplay with biochemical cues. In this work, we demonstrate the potential of laser as a versatile technology for the direct fine-tuning of the topography of Bacterial nanocellulose (BNC) with bioinspired topographies and micropatterns on a cell size scale. Tw...
Introduction: Currently, the gold-standard treatment of progressive keratoconus (KC) is corneal collagen cross-linking (CXL), in which riboflavin and ultraviolet-A radiation increase the corneal biomechanical rigidity, arresting progression. However, post-operatory results vary significantly among patients. Although it has been suggested that corneal thickness, cone location and patient’s age are important fact...
The potential of nanomaterials in food technology is nowadays well-established. However, their commercial use requires a careful risk assessment, in particular concerning the fate of nanomaterials in the human body. Bacterial NanoCellulose (BNC), a nanofibrillar polysaccharide, has been used as a food product for many years in Asia. However, given its nano-character, several toxicological studies must be perfor...
The potential of nanomaterials in food technology is nowadays well-established. However, their commercial use requires a careful risk assessment, in particular concerning the fate of nanomaterials in the human body. Bacterial nanocellulose (BNC), a nanofibrillar polysaccharide, has been used as a food product for many years in Asia. However, given its nano-character, several toxicological studies must be perfor...
Although surgical management of peripheral nerve injuries (PNIs) has improved over time, autographs are still the current â gold standardâ treatment for PNIs, which presents numerous limitations. In an attempt to improve natural biomaterial-based nerve guidance conduits (NGCs), chitosan (CHT), a derivative of the naturally occurring biopolymer chitin, has been explored for peripheral nerve regeneration (PNR). I...
Introdução – O carcinoma gástrico constitui a terceira causa oncológica de morte em Portugal. A metastização ganglionar, em particular a relação entre o número de gânglios ressecados e o número de gânglios metastizados, constitui o mais importante factor de prognóstico independente no carcinoma gástrico. A metastização das cadeias ganglionares distais assume um significado prognóstico pejorativo e condiciona as...
Aim: In this retrospective study we investigated the clinical relevance of focal increased 68Ga‐DOTANOC uptake in the thyroid gland in patients with no previous history of thyroid disease. The aim was to assess the incidence of malignant disease in these incidental findings and to inspect the potential diagnostic SUVmax ability to differentiate malignant from benign lesions. Material and methods: A total of 954...
Na actualidade, o progresso do rendimento desportivo ao mais alto nível só é susceptível de ser conseguido através de uma combinação (que diríamos necessariamente feliz) de um vasto conjunto de factores: é necessário desde logo um pouco de sorte (como em tudo na vida – mesmo que seja para cozinhar a sopa de pedra requerida), mas sobretudo um praticante talentoso e motivado, condições de treino adequadas, um env...