90 documents found, page 1 of 9
Carbon footprint assessment of microalgal biomass production, hydrothermal liqu...
Pires, Renata; Silva, Tiago; Ribeiro, Cláudia; Costa, Luis; Matos, Cristina T.; Costa, Paula; Lopes, Tiago; Gírio, Francisco; Silva, CarlaABSTRACT: Industrial liquid effluents (e.g., from fertilizer industry) and flue gas streams (e.g., CO2-rich, from cement industry) arise as an opportunity for waste valorization. Microalgae are suitable biomass for assimilating both effluents at the cultivation stage. Under a biorefinery concept, given the urge for energy transition in the aviation sector, this research explores the transformation of a microalg...
Carbon footprint assessment of microalgal biomass production, hydrothermal liqu...
Pires, Renata; Silva, Tiago; Ribeiro, Cláudia; Costa, Luis; Matos, Cristina T.; Costa, Paula; Lopes, Tiago; Gírio, Francisco; Silva, CarlaABSTRACT: Industrial liquid effluents (e.g., from fertilizer industry) and flue gas streams (e.g., CO2-rich, from cement industry) arise as an opportunity for waste valorization. Microalgae are suitable biomass for assimilating both effluents at the cultivation stage. Under a biorefinery concept, given the urge for energy transition in the aviation sector, this research explores the transformation of a microalg...
Retro tIming: A multicentric retrospective analysis of immunotherapy timing in ...
Gonçalves, Lisa; Goncalves, Duarte; Casanelles, Teresa Esteban; Guerra, Laura Pratas; Menezes, Maria B.; Branco, Vanessa Duarte; Luís, Joana AlvesImmune checkpoint inhibitors (ICI) targeting programmed cell death protein 1 (PD-1) and cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) are now the standard of care in the treatment of metastatic melanoma (mM). The interplay between cancer cells and tumor microenvironment cells (e.g. immune cells) impacts cancer cell survival, local invasion, and metastatic dissemination. Chrono-immunotherapy is an emergin...
A case of success: complete response to Radium-223 in metastatic castration-res...
Soares De Pinho, Inês; Esperança Martins, Miguel; Machado, Bárbara; Dâmaso, Sara; Brás, Raquel; Cantinho, Guilhermina; Fernandes, Isabel; Costa, LuisRadium-223 dichloride (Ra223) is the first targeted alpha agent approved for treating metastatic castration-resistant prostate cancer (mCRPC) with bone-exclusive disease. A benefit in overall survival and time to the first symptomatic skeletal-related event was shown in the Alpharadin in Symptomatic Prostate Cancer Patients (ALSYMPCA) trial. However, this trial did not describe a bone scan response to Ra223, an...
Conceptual Design of an Autotrophic Multi-Strain Microalgae-Based Biorefinery: ...
Lopes, Tiago; Ortigueira, Joana; Matos, Cristina T.; Costa, Luis; Ribeiro, Cláudia; Reis, Alberto; Gírio, FranciscoABSTRACT: Microalgae represent a promising solution in addressing the impacts associated with the current agricultural and manufacturing practices which are causing irreparable environmental damage. Microalgae have considerable biosynthetic potential, being a rich source of lipids, proteins, and high-value compounds. Under the scope of the H2020-BBI MULTI-STR3AM project, an innovative large-scale production sys...
Modeling students’ behavioral engagement through different in-class behavior st...
Gomes, Samuel; Costa, Luis; Martinho, Carlos; Dias, João; Xexéo, Geraldo; Moura Santos, AnaBackground The growing necessity of providing better education, notably through the development of Adaptive Learning Systems (ALSs), leveraged the study of several psychological constructs to accurately characterize learners. A concept extensively studied in education is engagement, a multidimensional construct encompassing behavioral expression and motivational backgrounds. This metric can be used to not only ...
Using satellite data to monitor Groundwater drought in the Algarve region
Neves, Maria C.; Moreira, Elsa; Costa, LuisGroundwater drought presents significant economic and societal challenges, highlighting the need for effective monitoring and early warning systems at local and regional scales. Despite its vital role in water supply and irrigation, groundwater drought is often not adequately monitored in national operational systems. While the propagation of meteorological drought through hydrological systems has been extensiv...
A 3D-Printed Ceramics Innovative Firing Technique: A Numerical and Experimental...
Santos, Tiago; Ramani, Melinda; Devesa, Susana; Batista, Catarina; Franco, Margarida; Duarte, Isabel; Costa, Luis; Ferreira, Nelson; Alves, NunoAdditive manufacturing (AM), also known as three-dimensional (3D) printing, allows the fabrication of complex parts, which are impossible or very expensive to produce using traditional processes. That is the case for dinnerware and artworks (stoneware, porcelain and clay-based products). After the piece is formed, the greenware is fired at high temperatures so that these pieces gain its mechanical strength and ...
Clinical validation of a size-based microfluidic device for circulating tumor c...
Palmela Leitão, Tito; Corredeira, Patrícia; Kucharczak, Sandra; Rodrigues, Margarida; Piairo, Paulina; Rodrigues, Carolina; Alves, PatríciaRenal cell carcinoma (RCC) presents as metastatic disease in one third of cases. Research on circulating tumor cells (CTCs) and liquid biopsies is improving the understanding of RCC biology and metastases formation. However, a standardized, sensitive, specific, and cost-effective CTC detection technique is lacking. The use of platforms solely relying on epithelial markers is inappropriate in RCC due to the freq...
Immunotherapy around the clock: impact of infusion timing on stage IV melanoma ...
Gonçalves, Lisa; Gonçalves, Duarte; Esteban-Casanelles, Teresa; Barroso, Tiago; Soares De Pinho, Inês; Lopes Brás, Raquel; Esperança Martins, MiguelAlthough the impact of circadian timing on immunotherapy has yet to be integrated into clinical practice, chronoimmunotherapy is an emerging and promising field as circadian oscillations are observed in immune cell numbers as well as the expression of immunotherapy targets, e.g., programmed cell death protein-1 and its ligand programmed death ligand 1. Concurrent retrospective studies suggest that morning infus...