3 documents found, page 1 of 1
Comparative in vitro and in vivo antimalarial activity of the indole alkaloids ...
Silva, Luiz Francisco Rocha e; Montoia, Andréia; Amorim, Rodrigo C.N.; Melo, Márcia R.S.; Henrique, Marycleuma Campos; Nunomura, Sergio MassayoshiIndole alkaloids ellipticine (1), cryptolepine triflate (2a), rationally designed 11-(4-piperidinamino)cryptolepine hydrogen dichloride (2b) and olivacine (3) (an isomer of 1) were evaluated in vitro against Plasmodium falciparum and in vivo in Plasmodium berghei-infected mice. 1-3 inhibited P. falciparum (IC50 ≤ 1.4 μM, order of activity: 2b > 1 > 2a > 3). In vitro toxicity to murine macrophages was evaluated ...
In vitro susceptibility of Plasmodium falciparum Welch field isolates to infusi...
Silva, Luiz Francisco Rocha e; Magalhães, Pedro Melillo de; Costa, Mônica Regina Farias; Alecrim, Maria das Graças Costa; Chaves, Francisco Célio MaiaArtemisinin is the active antimalarial compound obtained from the leaves of Artemisia annua L. Artemisinin, and its semi-synthetic derivatives, are the main drugs used to treat multi-drug-resistant Plasmodium falciparum (one of the human malaria parasite species). The in vitro susceptibility of P. falciparum K1 and 3d7 strains and field isolates from the state of Amazonas, Brazil, to A. annua infusions (5 g dry...
In vitro inhibition of Plasmodium falciparum by substances isolated from Amazon...
Andrade Neto, Valter Ferreira de; Pohlit, Adrian Martin; Pinto, Ana Cristina da Silva; Silva, Ellen Cristina Costa; Nogueira, Karla LagosIn the present study, a quassinoid, neosergeolide, isolated from the roots and stems of Picrolemma sprucei (Simaroubaceae), the indole alkaloids ellipticine and aspidocarpine, isolated from the bark of Aspidosperma vargasii and A. desmanthum (Apocynaceae), respectively, and 4-nerolidylcatechol, isolated from the roots of Pothomorphe peltata (Piperaceae), all presented significant in vitro inhibition (more activ...