21 documents found, page 1 of 3
Visceral Adipose Tissue Bioenergetics Varies According to Individuals' Obesity ...
Topete, MV; Andrade, S; Bernardino, RL; Guimaraes, M; Pereira, AM; Oliveira, SB; Costa, MM; Nora, M; Monteiro, MP; Pereira, SSObesity is associated with complex adipose tissue energy metabolism remodeling. Whether AT metabolic reprogramming differs according to body mass index (BMI) and across different obesity classes is unknown. This study's purpose was to evaluate and compare bioenergetics and energy substrate preference of visceral adipose tissue (VAT) pertaining to individuals with obesity class 2 and class 3. VAT obtained from p...
Individuals with type 2 diabetes have higher density of small intestinal neurot...
Ferreira, FP; Pereira, SS; Costa, MM; Guimarães, M; Nicolai J Wewer Albrechtsen; Jens J Holst; Mário Nora; Monteiro, MPNeurotensin (NT) is a gastro-intestinal hormone involved in several pathways that regulate energy and glucose homeostasis. NT was hypothesized to act in synergy with incretin hormones to potentiate its anti-diabetic effects. Additionally, circulating NT levels were shown to rise after bariatric surgery-induced weight loss. Knowledge of NT-secreting cells distribution along the small intestine and its variation ...
Virulence factors in Staphylococcus associated with small ruminant mastitis: bi...
Andrade, NC; Laranjo, M; Costa, MM; Queiroga, Maria CristinaSmall ruminant mastitis is a serious problem, mainly caused by Staphylococcus spp. Different virulence factors affect mastitis pathogenesis. The aim of this study was to investigate virulence factors genes for biofilm production and antimicrobial resistance to -lactams and tetracyclines in 137 staphylococcal isolates from goats (86) and sheep (51). The presence of coa, nuc, bap, icaA, icaD, blaZ, mecA, mecC, te...
Mineralocorticoid receptor antagonists eplerenone and spironolactone modify adr...
Pereira, SS; Carvalho, LS; Costa, MM; Melo, A; Ferreira, IMPLVO; Gomez-Sanchez, CE; Monteiro, MP; Vinson, G; Pignatelli, DMineralocorticoid receptor antagonists (MRAs) are a class of anti-hypertensive drugs that act by blocking aldosterone action. The aim of this study was to evaluate whether the MRAs spironolactone and eplerenone influence adrenal cortical physiology and morphology. Spontaneous hypertensive rats (SHR, n = 18) and normotensive rats (WKY, n = 18) were randomly exposed to a daily dose of spironolactone (n = 6), eple...
Impact of Bariatric Surgery on Long-term Cardiovascular Risk: Comparative Effec...
Oliveira, SC; Neves, JS; Souteiro, P; Pedro, J; Magalhães, D; Guerreiro, V; Bettencourt-Silva, R; Costa, MM; Varela, A; Barroso, I; Freitas, PIntroduction: Several reports highlight bariatric surgery as an efficient and long-lasting strategy for weight loss. Herein, we aimed to evaluate the impact of bariatric surgery on 10-year cardiovascular disease (CVD) risk and to compare the effectiveness of different surgical procedures, employing the Framingham Risk Score (FRS). Methods: Retrospective longitudinal observational study of patients undergoing ba...
Incomplete pattern of steroidogenic protein expression in functioning adrenocor...
Pereira, SS; Costa, MM; Gomez-Sanchez, CE; Monteiro, MP; Pignatelli, DAutonomous steroid secretion is a common feature of adrenocortical carcinomas (ACC), although not always clinically evident owing to inefficient steroidogenesis with increased release of steroid precursors. Our study aim was to analyze the expression profile of four key proteins involved in the steroidogenesis cascade, in different adrenocortical tumors. Expression of proteins involved in steroidogenesis, namel...
ARMC5 Primary Bilateral Macronodular Adrenal Hyperplasia Associated with a Meni...
Ferreira, MJ; Pedro, J; Salazar, D; Costa, C; Aragão Rodrigues, J; Costa, MM; Grangeia, A; Castedo, JL; Carvalho, DPrimary bilateral adrenal macronodular hyperplasia is characterized by functioning adrenal macronodules and variable cortisol secretion. Familial clustering suggests a genetic cause that has been confirmed with the identification of some genetic mutations, including inactivating germline mutations, in armadillo repeat containing 5 (ARMC5) gene. The identification of the pathogenic variant enables the physician ...
Impact of Bariatric Surgery on Long-term Cardiovascular Risk: Comparative Effec...
Castro Oliveira, SC; Neves, JS; Souteiro, P; Pedro, J; Magalhaes, D; Guerreiro, V; Bettencourt Silva, R; Costa, MM; Varela, A; Barroso, I; Freitas, PIntroduction Several reports highlight bariatric surgery as an efficient and long-lasting strategy for weight loss. Herein, we aimed to evaluate the impact of bariatric surgery on 10-year cardiovascular disease (CVD) risk and to compare the effectiveness of different surgical procedures, employing the Framingham Risk Score (FRS). Methods Retrospective longitudinal observational study of patients undergoing bari...
Incomplete Pattern of Steroidogenic Protein Expression in Functioning Adrenocor...
Pereira, SS; Costa, MM; Gomez Sanchez, CE; Monteiro, M; Pignatelli, DAutonomous steroid secretion is a common feature of adrenocortical carcinomas (ACC), although not always clinically evident owing to inefficient steroidogenesis with increased release of steroid precursors. Our study aim was to analyze the expression profile of four key proteins involved in the steroidogenesis cascade, in different adrenocortical tumors. Expression of proteins involved in steroidogenesis, namel...
Controlo de mastites em pequenos ruminantes: utilização de própolis como altern...
Andrade, NPC; Costa, MM; Laranjo, M; Queiroga, Maria CristinaOs antimicrobianos e antisséticos são utilizados para o controlo das mastites. Esta prática conduz a eliminação de resíduos no leite e induz pressão de seleção sobre estirpes resistentes. É urgente desenvolver métodos para controlo de doenças utilizando substâncias com poder antimicrobiano que sejam seguras. A própolis é um produto formado pelas abelhas Apis melífera, que possui qualidades antim...