10 documents found, page 1 of 1
Ultrasound Monitoring of Skeletal Muscle Wasting and Relation to Nutritional In...
Rosa Domingues, Catarina; Rodeia, Simão; Francisco, Ana Rita; Santos, Laura; Cerca, Carolina; Costa, Madalena; Pinto, Vera; Fortuna, PhilipBackground: Critically ill patients frequently experience profound skeletal muscle (SM) wasting, to which early detection and effective clinical management remain significant challenges. Ultrasonography (US) provides early objective information about SM compared with usual functional tests. The characteristics of the optimal nutritional support are controversial. This observational study aimed to characterize t...
Preserving the Autonomy in Intensive Care Units: Patients Voting for General El...
Cochicho Ramalho, Ana; Costa, Madalena; da Costa, Pedro Gaspar; C. Rodeia, Simão; Fortuna, PhilipN/A; N/A
Smart waste management: a look on Portugal towards the SDG
Costa, Madalena; Madureira, Raquel Castro; Ferreira, CéliaIn a world in constant change and development, waste management has been seen as an important area and, therefore, a target for investment and environmental concern. Considering smart waste management methods, the goal of this work is to portray some relevant Municipal Portuguese smart waste implementation methods and describe several initiatives using intelligent methods seeking smart city development and towa...
A social receptiveness analysis on smart waste management: a case study for Por...
Costa, Madalena; Madureira, Raquel Castro; Ferreira, CéliaThe technical and operational implementation of smart waste management methods is a complex and time-consuming process and therefore there is a strong resistance to its adoption by the public. At the same time, we live in an era marked by the existence of a greater desire for change driven by environmental and social concerns and technological development towards smart city implementation. In this scenario, it ...
A mouse model reproducing the pathophysiology of neonatal group B streptococcal...
Bonifácio Andrade, Elva; Magalhães, Ana; Puga, Ana; Costa, Madalena; Bravo, Joana; Portugal, Camila Cabral; Ribeiro, Adília; Correia-Neves, MargaridaGroup B streptococcal (GBS) meningitis remains a devastating disease. The absence of an animal model reproducing the natural infectious process has limited our understanding of the disease and, consequently, delayed the development of effective treatments. We describe here a mouse model in which bacteria are transmitted to the offspring from vaginally colonised pregnant females, the natural route of infection. ...
A mouse model reproducing the pathophysiology of neonatal group B streptococcal...
Andrade, Elva Bonifácio; Magalhães, Ana; Puga, Ana; Costa, Madalena; Bravo, Joana; Portugal, Camila Cabral; Ribeiro, Adília; Correia-Neves, MGroup B streptococcal (GBS) meningitis remains a devastating disease. The absence of an animal model reproducing the natural infectious process has limited our understanding of the disease and, consequently, delayed the development of effective treatments. We describe here a mouse model in which bacteria are transmitted to the offspring from vaginally colonised pregnant females, the natural route of infection. ...
In vivo models in cancer research
Costa, Madalena; Quintela Vieira, Filipa; Silva, ReginaCancers figure among the leading causes of morbidity and mortality worldwide. Over the last decade there has been an extraordinary increase in our knowledge of the fundamental molecular processes that are involved in the development of cancer and its response to treatment. Studies in tissue culture have multiplied our acquaintance of cancer cell pathophysiology, mechanisms of transformation and strategies of su...
Adipocyte Secreted Factors Enhance Aggressiveness of Prostate Carcinoma Cells
Moreira, Ângela; Pereira, Sofia S.; Costa, Madalena; Morais, Tiago; Pinto, Ana; Fernandes, Rúben; Monteiro, Mariana P.Obesity has been associated with increased incidence and risk of mortality of prostate cancer. One of the proposed mechanisms underlying this risk association is the change in adipokines expression that could promote the development and progression of the prostate tumor cells. The main goal of this study was to evaluate the effect of preadipocyte and adipocyte secretome in the proliferation, migration and invas...
Vascular and apoptotic changes in the placode of myelomeningocele mice during t...
Reis, Joaquim L; Correia-Pinto, Jorge; Monteiro, Mariana P.; Costa, Madalena; Hutchins, Grover M.Object: Myelomeningocele (MMC) is a primary neurulation defect that is associated with devastating neurological disabilities in affected newborns. To better characterize the in utero neurodegenerative process of MMC, the authors investigated the changes in vascular organization, apoptosis, and the presence of inflammatory cells during gestation by using a mutant mouse model of MMC. Methods: The curly tail/loop ...
Gestão da Qualidade: uma experiência de Implementação da CAF
Freitas, Celeste; Medeiros, Pedro; Cabral, Susana; Rosa, António; Costa, Isaura; Costa, Madalena; Melo, Maria Graça; Craveiro, MartaNo contexto actual do processo de Modernização da Administração Pública e do recentemente aprovado Sistema Integrado da Avaliação de Desempenho da Administração Pública (SIADAP), está previsto a avaliação das organizações, a qual deve ser feita através do recurso à Auto-Avaliação. Através da aplicação da CAF - Common Assessment Framework, um modelo de auto-avaliação criado no âmbito da União Europeia especifica...