3 documents found, page 1 of 1
Characterization of the interaction of a novel anticancer molecule with PMMA, P...
Montenegro, Edwar D.; Nunes, Jamylle M.; Ramos, Igor F. S.; Almeida, Renata G.; Júnior, Eufrânio N. da Silva; Rizzo, Márcia S.; Silva-Filho, Edson C. daThe development of anticancer drugs is costly and time intensive. Computational approaches optimize the process by studying molecules such as naphthoquinones. This research explores the quantitative structure–activity relationship (QSPR) and molecular interactions among 2,2-dimethyl-3-((3-nitrophenyl)amino)-2,3-dihydronaphtho[1,2-b]furan-4,5-dione (QPhNO2), a Nor-β-Lapachone derivative with anticancer propertie...
Estudo fitoquímico, atividade antimicrobiana e citotóxica de espécimes de Leono...
Oliveira, Ana P.; Guimarães, Amanda L.; Pacheco, Alessandra G. M.; Araújo, Camila S.; Oliveira Júnior, Raimundo G.; Lavor, Érica M.; Silva, Mariana G.PHYTOCHEMICAL STUDY ON ANTIMICROBIAL AND CYTOTOXIC ACTIVITY OF SPECIMENS OF Leonotis nepetifolia L. R. (Br). Specimens of Leonotis nepetiflolia were obtained from cultivated and wild environments to verify their influences in chemical composition. Phytochemical analyses were conducted for the ethyl acetate phase obtained by partitioning the crude ethanol extract from the cultivated leaves of L. nepetifolia. In ...
Cytotoxic evaluation of substituted benzaldehydes
Rodrigues, Felipe A. R.; Oliveira, Augusto C. A.; Cavalcanti, Bruno C.; Costa, Marcília P.; Pessoa, Claudia; Souza, Marcus V. N. deA series of fifty-four commercial aldehydes have been synthesized and evaluated for their activity against peripheral blood mononuclear cells (PBMC) and four human cancer cell lines, exhibiting potent citotoxicity (IC50 ranging from 0.36 to 4.75 μg mL-1). The structureactivity relationship (SAR) analysis indicated that the number, the positions and the type of substituents attached into the aromatic and heteroa...