15 documents found, page 1 of 2
Building on the EU’s unique strategy for Artificial Intelligence (AI): can an e...
Costa, Maria InêsIn this article, the Author investigates the ethical principles espoused by the European Union’s (EU) policies on Artificial Intelligence (AI) and discuss their effectiveness in providing an ethical foundation for the entire process of developing and deploying AI in Europe. To this end, the scope of the term “ethics” in the regulatory process is analysed, and the extent to which ambiguity about its meaning can ...
The charter of fundamental rights of the european union: A commentary
Silveira, Alessandra; Cabral, Tiago Sérgio Alves; Coelho, Larissa Araújo; Costa, Maria InêsThis Commentary on the Charter of Fundamental Rights of the European Union revisits and updates the Portuguese version published in 2013. Following the best academic practices, several scholars of recognised scientific knowledge – of varying ages and worldviews – were asked to and gave us the honour of contributing. The result is a comprehensive article-by-article commentary to the Charter. Each author is fully...
Short Peripheral Venous Catheters Contamination and the Dangers of Bloodstream ...
Osório, Nádia; Oliveira, Vânia; Costa, Maria Inês; Santos-Costa, Paulo; Serambeque, Beatriz; Gama, Fernando; Adriano, David; Graveto, JoãoPeripheral venous catheters (PVCs) are the most used vascular access devices in the world. However, failure rates remain considerably high, with complications such as PVC-related infections posing significant threats to patients' well-being. In Portugal, studies evaluating the contamination of these vascular medical devices and characterizing the associated microorganisms are scarce and lack insight into potent...
Zinc: From Biological Functions to Therapeutic Potential
Costa, Maria Inês; Sarmento-Ribeiro, Ana Bela; Gonçalves, Ana CristinaThe trace element zinc (Zn) displays a wide range of biological functions. Zn ions control intercellular communication and intracellular events that maintain normal physiological processes. These effects are achieved through the modulation of several Zn-dependent proteins, including transcription factors and enzymes of key cell signaling pathways, namely those involved in proliferation, apoptosis, and antioxida...
AZD-7648, a DNA-PK Inhibitor, Induces DNA Damage, Apoptosis, and Cell Cycle Arr...
Lapa, Beatriz Santos; Costa, Maria Inês; Figueiredo, Diana; Jorge, Joana; Alves, Raquel; Monteiro, Ana Raquel; Serambeque, Beatriz; Laranjo, MafaldaThe non-homologous end joining pathway is vital for repairing DNA double-strand breaks (DSB), with DNA-dependent protein kinase (DNA-PK) playing a critical role. Altered DNA damage response (DDR) in chronic (CML) and acute myeloid leukemia (AML) offers potential therapeutic opportunities. We studied the therapeutic potential of AZD-7648 (DNA-PK inhibitor) in CML and AML cell lines. This study used two CML (K-56...
The legal concept of discrimination by association: where does it fit into the ...
Costa, Maria InêsPersonal autonomy, a core human rights principle, refers to the ability to both design and conduct the course of one’s life through making choices from a range of valuable options. This plays a pivotal role in the realm of equality and non discrimination, which are relevant in the context of the European Union (EU). Through case law, the concept of discrimination by association has emerged as a crucial step in ...
Short peripheral venous catheters contamination and the dangers of bloodstream ...
Osório, Nádia; Oliveira, Vânia; Costa, Maria Inês; Santos-Costa, Paulo; Serambeque, Beatriz; Gama, Fernando; Adriano, David; Graveto, JoãoPeripheral venous catheters (PVCs) are the most used vascular access devices in the world. However, failure rates remain considerably high, with complications such as PVC-related infections posing significant threats to patients’ well-being. In Portugal, studies evaluating the contamination of these vascular medical devices and characterizing the associated microorganisms are scarce and lack insight into potent...
Zinc Prevents DNA Damage in Normal Cells but Shows Genotoxic and Cytotoxic Effe...
Costa, Maria Inês; Lapa, Beatriz Santos; Jorge, Joana; Alves, Raquel; Carreira, Isabel Marques; Sarmento-Ribeiro, Ana Bela; Gonçalves, Ana CristinaGenomic instability is prevented by the DNA damage response (DDR). Micronutrients, like zinc (Zn), are cofactors of DDR proteins, and micronutrient deficiencies have been related to increased cancer risk. Acute myeloid leukemia (AML) patients commonly present Zn deficiency. Moreover, reports point to DDR defects in AML. We studied the effects of Zn in DDR modulation in AML. Cell lines of AML (HEL) and normal hu...
Demographic ageing and vulnerability in the European Union: a brief analysis of...
Costa, Maria InêsThe pronounced ageing of the European population has multidimensional repercussions at the socio-economic level, which the European Union has been addressing. In this context, concerns about intergenerational solidarity and social sustainability are gaining prominence and constitute the cornerstones of the life-cycle approach embodied in the European Commission’s Green Paper on Ageing: Fostering solidarity and ...
Os direitos humanos numa Europa à procura de antídotos culturais contra a barbárie
Silveira, Alessandra; Costa, Maria Inês[Excerto] Tive o privilégio de partilhar a lecionação de algumas unidades curriculares com Benedita Mac Crorie – desde as suas primeiras aulas aos caloiros da licenciatura em Direito na UMinho, até as suas últimas aulas à distância aos mestrandos em Direitos Humanos em outubro de 2021. Quando trocávamos impressões para a atribuição de notas aos mestrandos, sempre me impressionou a diligência com que Benedita li...