19 documents found, page 1 of 2
Dissection of the microRNA transcriptomes of CD4+ T cell subsets in autoimmune ...
Cunha, Carolina; Romero, Paula Vargas; Inácio, Daniel; Pais, Ana Teresa; Pelicano, Catarina; Costa, Marina; Mensurado, Sofia; Gonçalves-Sousa, NatachaMicroRNAs (miRNAs) are key regulators of CD4+ T cell differentiation, but how they contribute to the course of an autoimmune disease in vivo remains poorly studied. Given the known roles in autoimmunity of pro-inflammatory T helper 1 (Th)1 and Th17 cells, and anti-inflammatory Foxp3+ regulatory cells, we established a triple reporter mouse for Ifng, Il17 and Foxp3, and subjected it to experimental autoimmune en...
PratyOmics - Metabolómica da planta para o controlo do nemátode das lesões radi...
Barbosa, Pedro; Costa, Marina; Espada, Margarida; Teixeira, Dora; Brás, Teresa; Duarte, Fátima; Figueiredo, Joana; Cardoso, Joana; Esteves, IvâniaO nemátode-das-lesões-radiculares (NLR), Pratylenchus penetrans, é um endoparasita migratório que afeta culturas agrícolas economicamente importantes, como a batata, estando atualmente presente na lista de pragas reguladas não sujeitas a quarentena A2 da União Europeia (UE 2016/2031). Em alguns países europeus, como Portugal, esta espécie foi detetada em campos de produção de batata estando relacionada com o se...
Chitosan Salts as Stabilizing Agents for the synthesis of Silver Nanoparticles ...
Carreiro, Elisabete P.; Teixeira, António P.S.; Costa, Marina; Burke, Anthony J.; Filho, Cesar; Gonçalves, Isabel; Craveiro, Alexandre; Silva, MaraIn this work, silver nanoparticles (AgNPs) were obtained by a chemical reduction method using different chitosan salts as stabilizing agents, able to protect and prevent against the aggregation of the nanoparticles. Various chitosan salts with different organic acids, which included: acetic, succinic, formic, propionic, malic, glycolic and lactic acid were used to form the chitosan salts. The use of these organ...
Developing sustainable approaches for the control of plant- parasitic nematodes...
Barbosa, Pedro; Mendonça, Madalena; Costa, Marina; Gutiérrez-Gutiérrez, Carlos; Mota, Manuel; Espada, Margarida; Vicente, Cláudia S. L.Plant-parasitic nematodes (PPN) are a serious threat for economically important crops worldwide, severely affecting the sustainability of the agricultural and forestry systems. Some PPNs are listed as quarantine pests for which restrictive regulations are imposed by phytosanitary authorities. Preventive control management strategies can help in the early detection of these pathogens. At Nemalab (Laboratory of N...
A molecular and spectrometric approach for tracing the origin of ancient ivory
Costa, Marina; Vicente, Cláudia S. L.; Espada, Margarida; Faria, Jorge; Teixeira, Jorge; Bettencourt, José; Teixeira, DoraThe remains recovered from ancient shipwrecks are a unique cultural, historical and archaeological heritage. The Horta Bay shipwreck (site BH-001), located at Faial Island, Azores archipelago, Portugal, was partially excavated between 2008 and 2012 and became of particular interest to scientists due to the quantity and diversity of artefacts recovered, with special emphasis to a vast elephant tusks collection o...
Elucidation of the nematicidal mode of action of 3-octanol on the root-lesion n...
Barbosa, Pedro; Costa, Marina; Espada, Margarida; Figueiredo, Ana Cristina; Mota, Manuel; Vicente, Cláudia S. L.The root-lesion nematode (RLN), Pratylenchus penetrans, is one of the most severe plant parasitic nematodes (PPN), responsible for productivity losses in a significant number of plant hosts. The chemical control of these PPNs relies on fumigants and non-fumigants compounds, which offer a systemic protection. Such control methods are costly and hazardous to the environment and to humans. Compounds naturally prod...
Dissecting the role of microRNAs in effector versus regulatory CD4+ T cell diff...
Cunha, Carolina; Romero, Paula Vargas; Inácio, Daniel; Pais, Ana Teresa; Pelicano, Catarina; Sobral, Daniel; Costa, Marina; Mensurado, SofiaIntroduction: MicroRNAs (miRNAs) are small non-coding RNAs that negatively regulate gene expression at the post-transcriptional level. They have been implicated in the regulation of the differentiation and function of CD4+ T cell subsets, key players in host defense against pathogens, but also responsible for immune-mediated diseases depending on the correct vs incorrect balance, respectively, between pro-infla...
Overlap between marine predators and proposed Marine Managed Areas on the Patag...
Baylis, Alastair; Lecea, Ander M. De; Tierney, Megan; Orben, Rachael; Ratcliffe, Norman; Wakefield, Ewan; Catry, Paulo; Campioni, Letizia; Costa, MarinaAbstract. Static (fixed-boundary) protected areas are key ocean conservation strategies, and marine higher predator distribution data can play a leading role toward identifying areas for conservation action. The Falkland Islands are a globally significant site for colonial breeding marine higher predators (i.e., seabirds and pinnipeds). However, overlap between marine predators and Falkland Islands proposed Mar...
From settlers to subspecies: genetic differentiation in Commerson’s dolphins be...
Kraft, Sebastian; Pérez-Alvarez, MJosé; Olavarría, Carlos; Moraga, Rodrigo; Baker, C. Scott; Steel, Debbie; Tixier, Paul; Guinet, ChristopheCommerson’s dolphins (Cephalorhynchus commersonii) are separated into the subspecies C. c. commersonii, found along southern South America (SA) and the Falkland Islands/Islas Malvinas (FI/IM), and C. c. kerguelenensis, restricted to the subantarctic Kerguelen Islands (KI). Following the dispersal model proposed for the genus, the latter is thought to have originated from SA after a long-distance dispersal event...
Design, Synthesis, and In Vitro Evaluation of Hydroxybenzimidazole-Donepezil An...
Chaves, Sílvia; Resta, Simonetta; Rinaldo, Federica; Costa, Marina; Josselin, Romane; Gwizdala, Karolina; Piemontese, Luca; Capriati, VitoA series of multi-target-directed ligands (MTDLs), obtained by attachment of a hydroxyphenylbenzimidazole (BIM) unit to donepezil (DNP) active mimetic moiety (benzyl-piperidine/-piperazine) was designed, synthesized, and evaluated as potential anti-Alzheimer's disease (AD) drugs in terms of biological activity (inhibition of acetylcholinesterase (AChE) and β-amyloid (Aβ) aggregation), metal chelation, and neuro...