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NMR metabolomics to study the metabolic response of human osteoblasts to non-po...

Araújo, Rita; Carneiro, Tatiana J.; Marinho, Paula; Costa, Marisa Maltez da; Roque, Ana; Silva, Odete A. B. da Cruz e; Fernandes, Maria Helena

Untargeted nuclear magnetic resonance (NMR) metabolomics was employed, for the first time to our knowledge, to characterize the metabolome of human osteoblast (HOb) cells and extracts in the presence of non-poled or negatively poled poly-L-lactic acid (PLLA). The metabolic response of these cells to this polymer, extensively used in bone regeneration strategies, may potentially translate into useful markers ind...

Date: 2019   |   Origin: RIA - Repositório Institucional da Universidade de Aveiro
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