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Aripiprazole offsets mutant ATXN3-induced motor dysfunction by targeting dopami...
Jalles, Ana; Vieira, Cármen Maria Leal; Pereira-Sousa, Joana; Campos, Daniela Vilasboas; Mota, Ana Francisca; Vasconcelos, SaraThe atypical antipsychotic aripiprazole is a Food and Drug Administration-approved drug for the treatment of psychotic, mood, and other psychiatric disorders. Previous drug discovery efforts pinpointed aripiprazole as an effective suppressor of Machado–Joseph disease (MJD) pathogenesis, as its administration resulted in a reduced abundance and aggregation of mutant Ataxin-3 (ATXN3) proteins. Dopamine partial ag...
Neurotherapeutic effect of Hyptis spp. leaf extracts in Caenorhabditis elegans ...
Vilasboas-Campos, Daniela; Costa, Marta Daniela Araújo; Castro, Andreia Cristiana Teixeira; Rios, Rejaine; Silva, Fabiano Guimarães; Bessa, CarlosHyptis suaveolens (HS), Hyptis pectinata (HP) and Hyptis marrubioides (HM) are plants used in folk medicine for treatment of several diseases. Here, we tested the in vivo antioxidant and neuroprotective potential of methanolic extracts from these plants, containing several rosmarinic acid derivatives and isoquercetin. In C. elegans, HS, HP and HM leaf extracts enhanced the antioxidant responses through the indu...