5 documents found, page 1 of 1
HIV-1-Transmitted Drug Resistance and Transmission Clusters in Newly Diagnosed ...
Pingarilho, M; Pimentel, V; Miranda, M; Silva, AR; Diniz, A; Ascenção, B; Piñeiro, C; Koch, C; Rodrigues, C; Caldas, C; Morais, C; Faria, DObjective: To describe and analyze transmitted drug resistance (TDR) between 2014 and 2019 in newly infected patients with HIV-1 in Portugal and to characterize its transmission networks. Methods: Clinical, socioepidemiological, and risk behavior data were collected from 820 newly diagnosed patients in Portugal between September 2014 and December 2019. The sequences obtained from drug resistance testing were us...
Cognitive impairment and markers of optical neurodegeneration in early multiple...
Silva, R; Coelho, P; Seabra, M; Laranjinha, I; Vieira, D; Costa, O; Jesus, J; Fonseca, AC; Costa, S; Ferreira, I; Lemos, J; Sousa, C; Vale, J; Sá, MJIntroduction: Cognitive impairment and retinal atrophy have been proposed as two potential markers of neurodegeneration in multiple sclerosis (MS). We aimed at assessing the relation between peripapillary retinal nerve fiber layer (pRNFL) and macular ganglion cell layer (mGCL) atrophy and cognitive performance in early MS. Methods: This is a multicenter cross-sectional study on patients with early MS (clinicall...
Comparison of Nasopharyngeal Samples for SARS‐CoV ‐2 Detection in a Paediatric ...
Rodrigues, J; Gouveia, C; Santos, MA; Costa, O; Côrte‐Real, R; Brito, MJAim: The diagnosis of coronavirus disease 2019 (COVID-19) depends on accurate and rapid testing. Choosing an appropriate sample may impact diagnosis. Naso-oropharyngeal swabs (NOS) are most frequently used, despite several limitations. Since studies suggest nasopharyngeal aspirate (NPA) as a superior alternative in children, we hypothesised collecting both nasopharyngeal swab and aspirate would improve our diag...
Can an intradialytic snack model compensate the catabolic impact of hemodialysis?
Martins, VS; Adragao, T; Aguiar, L; Fortes, A; Costa, O; Borges, Nuno; Calhau, C; Macario, FBackground and aims: Hemodialysis (HD) has a catabolic effect caused by alterations in protein metabolism, increase in resting energy expenditure (REE) and protein needs due to inflammation, HD circuit blood and heat losses, protein losses to dialysate and HD filter membrane biocompatibility. We aim to determine, as a proof of concept, whether a standardized intradialytic snack model is adequate to compensate t...
Impact of maternal body mass index and gestational weight gain on pregnancy com...
Santos, S; Voerman, E; Amiano, P; Barros, H; Beilin, LJ; Bergström, A; Charles, MA; Chatzi, L; Chevrier, C; Chrousos, GP; Corpeleijn, E; Costa, OObjective To assess the separate and combined associations of maternal pre-pregnancy body mass index (BMI) and gestational weight gain with the risks of pregnancy complications and their population impact. Design Individual participant data meta-analysis of 39 cohorts. Setting Europe, North America, and Oceania. Population 265 270 births. Methods Information on maternal pre-pregnancy BMI, gestational weight gai...