2 documents found, page 1 of 1
Induction of G2/M arrest, caspase activation and apoptosis by a-santonin deriva...
Ferreira, José Roberto Oliveira; Cavalcanti, Bruno Coêlho; Costa, Patricia Marçal da; Arantes, Francisco Frederico Perlinson deSesquiterpene lactones (SLs) are natural products with a variety of biological activities. Previously, we demonstrated the cytotoxic effects of three new a-santonin derivatives on different tumor cell lines with low toxic effects upon peripheral human leukocytes. Here, we evaluated the mechanism of action triggered by these derivatives. HL-60 cell cycle determined after 24 h treatment revealed a significant inh...
Avaliação do potencial antitumoral e antiangiogênico de novos análogos ftalimíd...
Costa, Patricia Marçal daThe thalidomide was previously used to relieve gastric discomforts during pregnancy, and currently it is used for cancer treatment and inflammatory illnesses. Various phthalimides analogues of thalidomide have been researched for its antiangiogenic and immunemodulatory activity. In previous studies, these analogues showed absence of immunesuppressor activity. In this context, this work initially determined the ...