10 documents found, page 1 of 1
Monoterpene hydroxy lactones isolated from Thalassiosira sp. microalga and thei...
Morais, Alcina M. M. B.; Kumla, Decha; Martins, Valter F. R.; Alves, Ana; Gales, Luis; Silva, Artur M. S.; Costa, Paulo M.; Mistry, SharadTwo monoterpenoid lactones, loliolide (1) and epi-loliolide (2), were isolated from the crude dichloromethane extract of a microalga, Thalassiosira sp.). The structures of loliolide (1) and epi-loliolide (2) were elucidated by 1D and 2D NMR analysis, as well as a comparison of their 1H or/and 13C NMR data with those reported in the literature. In the case of loliolide (1), the absolute configurations of its ste...
International external validation of risk prediction model of 90-day mortality ...
Dal Cero, Mariagiulia; Gibert, Joan; Grande, Luis; Gimeno, Marta; Osorio, Javier; Bencivenga, Maria; Fumagalli Romario, Uberto; Rosati, RiccardoBackground: Radical gastrectomy remains the main treatment for gastric cancer, despite its high mortality. A clinical predictive model of 90-day mortality (90DM) risk after gastric cancer surgery based on the Spanish EURECCA registry database was developed using a matching learning algorithm. We performed an external validation of this model based on data from an international multicenter cohort of patients. Me...
IPOscore: an interactive web-based platform for postoperative surgical complica...
Mochão, Hugo; Gonçalves, Daniel; Alexandre, Leonardo; Castro, Carolina; Valério, Duarte; Barahona, Pedro; Moreira-Gonçalves, Daniel; Costa, Paulo M.Background: The performance of traditional risk score systems to predict (post)-operative outcomes is limited. This weakness reduces confidence in its use to support clinical risk mitigation decisions. However, the rapid growth of health data in the last years offers principles to deal with some of these limitations. In this regard, the data allows the extraction of relevant information for both patients strati...
Genetic and microenvironmental intra-tumor heterogeneity impacts colorectal can...
Sobral, Daniel; Martins, Marta; Kaplan, Shannon; Golkaram, Mahdi; Salmans, Michael; Khan, Nafeesa; Vijayaraghavan, Raakhee; Casimiro, SandraColorectal cancer (CRC) is a highly diverse disease, where different genomic instability pathways shape genetic clonal diversity and tumor microenvironment. Although intra-tumor heterogeneity has been characterized in primary tumors, its origin and consequences in CRC outcome is not fully understood. Therefore, we assessed intra- and inter-tumor heterogeneity of a prospective cohort of 136 CRC samples. We demon...
Methods for conducting international Delphi surveys to optimise global particip...
Alkhaffaf, Bilal; Blazeby, Jane M.; Metryka, Aleksandra; Glenny, Anne-Marie; Adeyeye, Ademola; Costa, Paulo M.; del Val, Ismael DiezBackground: Core outcome sets (COS) should be relevant to key stakeholders and widely applicable and usable. Ideally, they are developed for international use to allow optimal data synthesis from trials. Electronic Delphi surveys are commonly used to facilitate global participation; however, this has limitations. It is common for these surveys to be conducted in a single language potentially excluding those not...
The impact of negative lymph nodes in the survival outcomes of pN+ patients fol...
Costa, Paulo M.; Lages, Patrícia; Onofre, Susana; Ribeiro, Ruy M.The impact of negative lymph nodes (LNs) on survival of pN+ patients has been recognized. The weight of negative LNs in an inverse lymph node ratio (nR) should be related to its prognostic impact. Five hundred and two consecutive gastric cancer patients, who underwent radical gastrectomy, were included. Patients were split into groups according to the number of harvested nodes and a cross-tabulation with pTNM s...
Incidence and grading of complications after gastrectomy for cancer using the G...
Baiocchi, Gian Luca; Giacopuzzi, Simone; Reim, Daniel; Piessen, Guillaume; Costa, Paulo M.; Reynolds, John V; Meyer, Hans-Joachim; Morgagni, PaoloObjective: Utilizing a standardized dataset based on a newly developed list of 27 univocally defined complications, this study analyzed data to assess the incidence and grading of complications and evaluate outcomes associated with gastrectomy for cancer in Europe. Summary background data: The absence of a standardized system for recording gastrectomy-associated complications makes it difficult to compare resul...
International consensus on a complications list after gastrectomy for cancer
Baiocchi, Gian Luca; Giacopuzzi, Simone; Marrelli, Daniele; Reim, Daniel; Piessen, Guillaume; Costa, Paulo M.; Reynolds, John V.; Meyer, Hans-JoachimBackground: Perioperative complications can affect outcomes after gastrectomy for cancer, with high mortality and morbidity rates ranging between 10 and 40%. The absence of a standardized system for recording complications generates wide variation in evaluating their impacts on outcomes and hinders proposals of quality-improvement projects. The aim of this study was to provide a list of defined gastrectomy comp...
Therapy-induced cellular senescence induces epithelial-to-mesenchymal transitio...
Tato-Costa, Joana; Casimiro, Sandra; Pacheco, Teresa; Pires, Ricardo; Fernandes, Afonso; Alho, Irina; Pereira, Pedro; Costa, Paulo M.Introduction: DNA damaging agents and ionizing radiation used in the therapy of human cancers can induce senescence of cancer cells. Senescent cells exhibit a secretory phenotype (senescence-associated secretome [SAS]) that can affect cancer cell behavior and, eventually, clinical prognosis. We assessed the effects of the SAS on the induction of epithelial-to-mesenchymal transition (EMT) in vitro and in clinica...
Anthracyclines induce DNA damage response-mediated protection against severe se...
Figueiredo, Nuno; Chora, Ângelo Ferreira; Raquel, Maria Helena; Pejanovic, Nadja; Pereira, Pedro; Hartleben, Björn; Neves-Costa, Ana; Moita, CatarinaSevere sepsis remains a poorly understood systemic inflammatory condition with high mortality rates and limited therapeutic options in addition to organ support measures. Here we show that the clinically approved group of anthracyclines acts therapeutically at a low dose regimen to confer robust protection against severe sepsis in mice. This salutary effect is strictly dependent on the activation of DNA damage ...