5 documents found, page 1 of 1
Characterization of Th2 serum immune response in acute appendicitis
Carvalho, Nuno; Almeida, Jani-Sofia; Carolino, Elisabete; Lopes, Francisco; Henriques, Susana; Vaz, João; Coelho, Hélder; Santos, Paulo RodriguesAcute Appendicitis (AA) is the commonest abdominal digestive surgical emergency, but its etiology is not clarified. Based on histologic observations, an allergic cause has been proposed. In a type I hypersensitivity allergic reaction, there is a Th2 immune response characterized by Th2 cells, eosinophils, basophils, IgE, IL-4, IL-5, and IL-13 serum elevation. Recent studies showed a local appendicular endolumin...
Tryptase in acute appendicitis: unveiling allergic connections through compelli...
Carvalho, Nuno; Carolino, Elisabete; Ferreira, Margarida; Coelho, Hélder; Santos, Catarina Rolo; Barreira, Ana Lúcia; Henriques, Susana; Cardoso, CarlosThe aetiology of acute appendicitis (AA), the most frequent abdominal surgical emergency, is still unclarified. Recent epidemiologic, clinical, and laboratory data point to an allergic component in the pathophysiology of AA. Mastocytes participate in the Th2 immune response, releasing inflammatory mediators from their granules upon stimulation by IgE-specific antigens. Among the well-known mediators are histami...
Eosinophil granule proteins involvement in acute appendicitis: an allergic dise...
Carvalho, Nuno; Carolino, Elisabete; Coelho, Hélder; Barreira, Ana Lúcia; Moreira, Luísa; André, Margarida; Henriques, Susana; Cardoso, CarlosSeveral pieces of evidence point to an allergic component as a trigger of acute appendicitis. As the Th2 immune response is characterized by eosinophil mobilization to the target organ and release of their cationic granule proteins, it is reasonable to investigate if the degranulation of eosinophils could be associated with the local injury. The primary aim of this study is to evaluate the participation of eosi...
THYROID AUTO-IMMUNITY AS A RISK FACTOR FOR RECURRENT MULTINODULAR GOITER AFTER ...
Borges, Filipe; Marques, Ricardo; Nascimento, Isabel; Raimundo, Luísa; Portugal, Jorge; Costa, Paulo MatosBackground. The ideal surgical strategy to multinodular goiter (MNG) is currently still matter of discussion. Thyroid auto- immunity is a well-known risk factor for hypothyroidism and could play a role in MNG’s physiopathology. Objective. Assess thyroid auto-immunity as a risk factor for MNG recurrence. Materials and Methods. Retrospective analysis of a 5-year (January 2012 – December 2016) prospective dat...
IL-5 serum and appendicular lavage fluid concentrations correlate with eosinoph...
Carvalho, Nuno; Carolino, Elisabete; Coelho, Hélder; Cóias, Ana; Trindade, Madalena; Vaz, João; Cismasiu, Brigitta; Moita, Catarina; Moita, LuisAppendicitis is the most common abdominal surgical emergency, but its aetiology is not fully understood. We and others have proposed that allergic responses play significant roles in its pathophysiology. Eosinophils and Interleukin (IL)-5 are involved in a hypersensitivity type I reaction. Eosinophil infiltration is common in the allergic target organ and is dependent on IL-5. In the presence of an allergic com...