45 documents found, page 1 of 5
Assessment of the Genotoxic Hazard of Estuarine Sediments Using an Integrative ...
Pinto, Miguel; Sacadura, Joana; Costa, Pedro M.; Caeiro, Sandra; Louro, Henriqueta; Silva, Maria J.Under the influence of multiple anthropogenic pressures, from industrial to agricultural activities, estuaries have long been regarded as particularly sensitive ecosystems to contamination. The present study aimed at investigating the genotoxic potential of a contaminated sediment sample from an urban and industrial area of the Sado Estuary, by combining the analysis of multiple endpoints in the <jats:italic>La...
Endogenous Fluorescent Proteins in the Mucus of an Intertidal Polychaeta: Clues...
Rodrigo, Ana P.; Lopes, Ana; Pereira, Ricardo; Anjo, Sandra I.; Manadas, Bruno; Grosso, Ana R.; Baptista, Pedro V.; Fernandes, Alexandra R.The vast ocean holds many unexplored organisms with unique adaptive features that enable them to thrive in their environment. The secretion of fluorescent proteins is one of them, with reports on the presence of such compounds in marine annelids being scarce. The intertidal Eulalia sp. is an example. The worm secretes copious amounts of mucus, that when purified and concentrated extracts, yield strong fluoresce...
Differential effects of food restriction and warming in the two-spotted goby: I...
Lopes, Ana F.; Murdoch, Robyn; Cardoso, Sara D.; Madeira, Carolina; Costa, Pedro M.; Félix, Ana Sofia; Oliveira, Rui Filipe; Bandarra, NarcisaClimate change is a growing threat to marine organisms and ecosystems, and it is already modifying ocean properties by, for example, increasing temperature and decreasing pH. Increasing water temperature may also lead to an impairment of primary productivity and an overall depletion of available zooplankton. Understanding how the crossover between warming and zooplankton availability impacts fish populations ha...
Differential effects of food restriction and warming in the two-spotted goby: i...
Lopes, Ana F.; Murdoch, Robyn; Martins-Cardoso, Sara; Madeira, Carolina; Costa, Pedro M.; Félix, Ana S.; Oliveira, Rui F.; Bandarra, Narcisa M.Climate change is a growing threat to marine organisms and ecosystems, and it is already modifying ocean properties by, for example, increasing temperature and decreasing pH. Increasing water temperature may also lead to an impairment of primary productivity and an overall depletion of available zooplankton. Understanding how the crossover between warming and zooplankton availability impacts fish populations ha...
Specific Antiproliferative Properties of Proteinaceous Toxin Secretions from th...
Rodrigo, Ana P.; Mendes, Vera M.; Manadas, Bruno; Grosso, Ana R.; Alves de Matos, António P.; Baptista, Pedro V.; Costa, Pedro M.As Yondelis joins the ranks of approved anti-cancer drugs, the benefit from exploring the oceans' biodiversity becomes clear. From marine toxins, relevant bioproducts can be obtained due to their potential to interfere with specific pathways. We explored the cytotoxicity of toxin-bearing secretions of the polychaete Eulalia onto a battery of normal and cancer human cell lines and discovered that the cocktail of...
Different sensitivity to heatwaves across the life cycle of fish reflects pheno...
Madeira, Diana; Madeira, Carolina; Costa, Pedro M.; Vinagre, Catarina; Pörtner, Hans-Otto; Diniz, Mário S.Predicting responses of marine organisms to global change requires eco-physiological assessments across the complex life cycles of species. Here, we experimentally tested the vulnerability of a demersal temperate fish (Sparus aurata) to long-lasting heatwaves, on larval, juvenile and adult life-stages. Fish were exposed to simulated coastal (18 °C), estuarine (24 °C) summer temperatures, and heatwave conditions...
Different sensitivity to heatwaves across the life cycle of fish reflects pheno...
Madeira, Diana; Madeira, Carolina; Costa, Pedro M.; Vinagre, Catarina; Portner, Hans-Otto; Diniz, Mario S.Predicting responses of marine organisms to global change requires eco-physiological assessments across the complex life cycles of species. Here, we experimentally tested the vulnerability of a demersal temperate fish (Sparus aurata) to long-lasting heatwaves, on larval , juvenile and adult life-stages. Fish were exposed to simulated coastal (18 degrees C), estuarine (24 degrees C) summer temperatures, and heat...
Co-exposure to environmental carcinogens in vivo induces neoplasia-related hall...
Martins, Marta; Silva, Ana; Costa, Maria H.; Miguel, Célia; Costa, Pedro M.Addressing the risk of mixed carcinogens in vivo under environmentally-realistic scenarios is still a challenge. Searching for adequate biomarkers of exposure requires understanding molecular pathways and their connection with neoplasia-related benchmark pathologies. Subjecting the zebrafish model to realistic concentrations of two genotoxicants and carcinogens, cadmium and benzo[a]pyrene, isolated and combined...
Explorations on the ecological role of toxin secretion and delivery in jawless ...
Cuevas, N.; Martins, M.; Rodrigo, A. P.; Martins, C.; Costa, Pedro M.Motivated by biotechnological prospects, there is increasing evidence that we may just be scraping the tip of the iceberg of poisonous marine invertebrates, among which the Polychaeta are promising candidates for bioprospecting. Here we show that an inconspicuous phyllodocid uses toxins in its uncanny feeding strategy. The worm, a jawless active predator characterised by its bright green colour, preys on larger...
Multifunctional gold-nanoparticles: A nanovectorization tool for the targeted d...
Fernandes, Alexandra; Jesus, João; Martins, Pedro; Figueiredo, Sara; Rosa, Daniela; Martins, Luisa; Corvo, M. Luísa; Carvalheiro, ManuelaDue to their small size and unique properties, multifunctional nanoparticles arise as versatile delivery systems easily grafted with a vast array of functional moieties, such as anticancer cytotoxic chemotherapeutics and targeting agents. Here, we formulated a multifunctional gold-nanoparticle (AuNP) system composed of a monoclonal antibody against epidermal growth factor receptor (EGFR) (anti-EGFR D-11) for ac...