167 documents found, page 1 of 17

History of mental health problems moderates the association between partner sup...

Background: Partner support during childbirth is an important protective factor for women's perinatal mental health. However, its protective role in women experiencing vulnerabilities is largely unknown, namely in those with history of mental health problems. Aim: This study analysed (1) the association between partner support during childbirth and depressive, anxiety, and childbirth-related post-traumatic stre...

Silk fibroin microparticles as a candidate for wound healing applications: eval...

In this study, silk fibroin (SF) aerogel microparticles were developed as a delivery system for adenosine (ADO) to exploit its anti-inflammatory and regenerative properties for wound healing. Supercritical CO2 drying was used to prepare ADO-loaded SF aerogel microparticles with different SF concentrations (3 %, 5 %, 7 % w/v) and SF: ADO ratios (10:1, 5:1, 2:1). Characterization revealed high porosity (91–94 %),...

Endothelial dysfunction in cardiovascular diseases: mechanisms and in vitro models

Endothelial cells (ECs) are arranged side-by-side to create a semi-permeable monolayer, forming the inner lining of every blood vessel (micro and macrocirculation). Serving as the first barrier for circulating molecules and cells, ECs represent the main regulators of vascular homeostasis being able to respond to environmental changes, either physical or chemical signals, by producing several factors that regula...

Redefinindo os Cuidados: a Ética e a Jornada de Portugal para Cuidados de Saúde...

O uso ético de contenções físicas nas enfermarias médicas é uma questão fulcral que exige uma análise cuidadosa da autonomia, dignidade e segurança do doente. Este artigo explora o complexo panorama ético em torno da aplicação de contenções físicas, focando em princípios fundamentais como o respeito pela autonomia, a beneficência, a não maleficência e a justiça. As contenções devem ser justificadas por meio de ...

Microvascular, biochemical, and clinical impact of hyperbaric oxygen therapy in...

Background: Diabetic foot ulcers (DFUs) are a serious complication of diabetes and are often difficult to treat. Hyperbaric oxygen therapy (HBOT) has been proposed as an adjunctive treatment to promote healing, but its long-term clinical and biological effects remain insufficiently characterized. This study aimed to evaluate the impact of HBOT on systemic biomarkers, local microvasculature, and clinical outcome...

Correction to: Endothelial dysfunction in cardiovascular diseases: mechanisms a...

Advancing diabetes treatment: from human beta cell technology to bioartificial ...

In 2021, approximately 537 million people worldwide, primarily in low- and middle-income countries, were affected by diabetes, leading to approximately 6.7 million deaths annually or severe secondary complications including life-threatening hyperglycemia. For nearly 50 years, current therapeutic approaches include full pancreas transplantation and isolated pancreatic islets, more recently, cell therapy such as ...

Supercritical CO2-assisted decellularization: advanced pancreatic tissue platfo...

Introduction: Decellularization is a procedure that aims to remove the cellular and antigenic material of a tissue while preserving its extracellular matrix (ECM) and biological properties. Decellularized ECM offers a natural microenvironment with significant potential for use in cell-based therapies and tissue regeneration [1]. Different protocols have been employed to decellularize tissues and organs. However...

EEG signatures during pregnancy and their role on parenting-related measures: s...

This scoping review aims to map and synthesise the current research evidence targeting the electroencephalography (EEG) neural correlates during pregnancy and its association with parenting-related measures during pregnancy and postpartum period. Pregnancy is characterised by a wide range of biological changes associated with adaptation to parenthood. A growing body of literature has examined the neural correla...

Neurophysiological markers of cardiac interoceptive processing in first-time ex...

Pregnancy is a complex biological phenomenon where two distinct pathways may produce changes in interoception (ability to perceive and subjectively experience inner bodily states). First, pregnancy modifies the parental caregiving brain network, which includes key regions for interoceptive processing, particularly the insula. Second, pregnancy also changes the strength, frequency, and/or nature of interoceptive...