4 documents found, page 1 of 1
Reposicionamento do ácido alfa-lipóico na esquizofrenia: ensaio clínico aberto
Menezes, Carlos Eduardo de SouzaEvidence from previous experimental research has demonstrated the strong relationship between oxidative imbalance and the presence of various symptoms of schizophrenia. The antioxidant properties of alpha-lipoic acid (ALA), used as a adjuvant therapy for schizophrenia, produced positive results in these same studies. The objective of this clinical study was to demonstrate the repositioning of ALA in the treatme...
α-Lipoic acid as adjunctive treatment for schizophrenia : an open-label trial
Sanders, Lia Lira Olivier; Menezes, Carlos Eduardo de Souza; Chaves Filho, Adriano José Maia; Viana, Glautemberg de Almeida; Fechine, Francisco VagnaldoPurpose/Background: Accumulating evidence suggests an involvement of oxidative stress in the pathophysiology of schizophrenia. This offers a hypothesis-derived therapeutic approach to hinder oxidative damage and its clinical sequelae. α-Lipoic acid (ALA) is a powerful natural antioxidant indicated to treat diabetic neuropathy. Methods/Procedures: In this pilot investigation, we administered ALA (100 mg/d) for 4...
Alterações cogntivas e neuroquimicas pelo uso crônico de monoterapia e terapia ...
Menezes, Carlos Eduardo de SouzaDepression is a chronic and recurrent psychopathological condition, with obvious socio-occupational injury and quality of life in both the acute and long term. Depression is caused by afunctional deficit of monoamines in their signaling pathways (serotoninergic, dopaminergic, noradrenergic) in certain parts of the brain. Although there are various forms of clinical treatment of mood disorders such as psychother...
Behavioral and neurochemical effects of alpha-lipoic acid in the model of Parki...
Araújo, Dayane Pessoa de; Sousa, Caren Nádia Soares De; Araújo, Paulo Victor Pontes; Menezes, Carlos Eduardo de SouzaThis study aimed to investigate behavioral and neurochemical effects of -lipoic acid (100mg/kg or 200mg/kg) alone or associated with L-DOPA using an animal model of Parkinson’s disease induced by stereotaxic injection of 6-hydroxydopamine (6-OHDA) in rat striatum. Motor behavior was assessed by monitoring body rotations induced by apomorphine, open field test and cylinder test. Oxidative stress was accessed by ...