15 documents found, page 1 of 2
A transcriptomic signature mediated by HOXA9 promotes human glioblastoma initia...
Pojo, Marta; Gonçalves, Céline S.; Magalhães, Ana Xavier; Oliveira, Ana Isabel; Gonçalves, Tiago; Correia, Sara; Rodrigues, Ana JoãoGlioblastoma is the most malignant brain tumor, exhibiting remarkable resistance to treatment. Here we investigated the oncogenic potential of HOXA9 in gliomagenesis, the molecular and cellular mechanisms by which HOXA9 renders glioblastoma more aggressive, and how HOXA9 affects response to chemotherapy and survival. The prognostic value of HOXA9 in glioblastoma patients was validated in two large datasets from...
MET is required for the recruitment of anti-tumoural neutrophils
Finisguerra, Veronica; Conza, Giusy Di; Matteo, Mario Di; Serneels, Jens; Costa, Sandra Maria Araújo da; Thompson, A. A. Roger; Wauters, ElsMutations or amplification of the MET proto-oncogene are involved in the pathogenesis of several tumours, which rely on the constitutive engagement of this pathway for their growth and survival. However, MET is expressed not only by cancer cells but also by tumour-associated stromal cells, although its precise role in this compartment is not well characterized. Here we show that MET is required for neutrophil c...
Immunoglobulin genes implicated in glioma risk
Pandey, Janardan P.; Kaur, Navtej; Costa, Sandra Maria Araújo da; Amorim, Júlia; Nabiço, Rui; Linhares, Paulo; Vaz, Rui; Pereira, Marta VianaBoth genetic and environmental factors are thought to be causal in gliomagenesis. Several genes have been implicated in glioma development, but the putative role of a major immunity-related gene complex member, immunoglobulin heavy chain ? (IGHG) has not been evaluated. Prior observations that IGHG-encoded ? marker (GM) allotypes exhibit differential sensitivity to an immunoevasion strategy of cytomegalovirus, ...
HOXA9 promotes glioblastoma initiation, aggressiveness and resistance to therapy
Pojo, Marta; Gonçalves, Céline S.; Xavier-Magalhães, Ana; Oliveira, Ana Isabel; Costa, Sandra Maria Araújo da; Pinto, Luísa; Reis, R. M.; Rocha, MiguelGlioblastoma is the most common and malignant subtype of glioma, exhibiting remarkable resistance to treatment. Here we investigated the oncogenic potential of HOXA9 in gliomagenesis, the molecular and cellular mechanisms by which HOXA9 may render glioblastoma more aggressive, and how HOXA9 affects response to chemotherapy and prognosis. Expression microarrays were used to identify HOXA9 target genes. Stable gl...
PHD2 regulates arteriogenic macrophages through TIE2 signaling
Hamm, Alexander; Veschini, Lorenzo; Takeda, Yukiji; Costa, Sandra Maria Araújo da; Delamarre, Estelle; Squadrito, Mario Leonardo; Henze, Anne-TheresOcclusion of the main arterial route redirects blood flow to the collateral circulation. We previously reported that macrophages genetically modified to express low levels of prolyl hydroxylase domain protein 2 (PHD2) display an arteriogenic phenotype, which promotes the formation of collateral vessels and protects the skeletal muscle from ischaemic necrosis. However, the molecular mechanisms underlying this pr...
Characterization of PAR1 and FGFR1 expression in invasive breast carcinomas : p...
Tiburcio, Marta; Costa, Sandra Maria Araújo da; Duarte, Maria de Fátima Pereira; Schmitt, Fernando C.; Filho, A. L.Breast cancer is the most common cause of cancer mortality among women worldwide. Among the several factors associated with breast cancer development, angiogenesis plays an essential role and has currently emerged as a potential diag¬nostic, prognostic and therapeutic target. Protease-activated receptor 1 (PAR1) and fibroblast growth factor receptor 1 (FGFR1) have important activities in tumor angiogenesis and ...
Macrophage skewing by Phd2 haplodeficiency prevents ischemia by inducing arteri...
Takeda, Yukiji; Costa, Sandra Maria Araújo da; Delamarre, Estelle; Roncal, Carmen; Oliveira, Rodrigo Leite de; Squadrito, Mario LeonardoPHD2 serves as an oxygen sensor that rescues blood supply by regulating vessel formation and shape in case of oxygen shortage. However, it is unknown whether PHD2 can influence arteriogenesis. Here we studied the role of PHD2 in collateral artery growth by using hindlimb ischaemia as a model, a process that compensates for the lack of blood flow in case of major arterial occlusion. We show that Phd2 (also known...
Association between EGF +61A/G polymorphism and gastric cancer in Caucasians
Araújo, Ana Paula; Costa, Bruno Marques; Correia, Ana L. Pinto; Fragoso, Maria; Ferreira, Paula; Ribeiro, Mário Dinis; Costa, Sandra Maria Araújo daTo investigate the association between epidermal growth factor (EGF) +61A/G polymorphism and susceptibility to gastric cancer, through a cross-sectional study. METHODS: Polymerase chain reaction resctriction fragment lenght polymorphism analyses were used to genotype EGF +61 in 207 patients with gastric lesions (162 patients with gastric adenocarcinomas, 45 with atrophy or intestinal metaplasia) and 984 control...
TP53 codon 72 polymorphism in susceptibility, overall survival, and adjuvant th...
Lima-Ramos, Vítor; Pacheco-Figueiredo, Luís; Costa, Sandra Maria Araújo da; Pardal, Fernando; Silva, Ana; Amorim, Júlia; Lopes, José Manuel; Reis, R. M.TP53 is a key tumor suppressor gene that encodes a transcriptional factor involved in several cellular mechanisms, including growth arrest, DNA repair, and induction of apoptosis. In addition to TP53 gene mutations, a common polymorphism, Arg72Pro, has been involved in the carcinogenesis process. The Pro72 variant has been associated with a slower induction of apoptosis and may influence the risk of cancer deve...
DNA repair genetic polymorphisms and breast cancer in the Portuguese population
Costa, Sandra Maria Araújo daBreast cancer is the leading cause of death among women in developing countries. Approximately 10% of all cases of breast cancer are inherited, exhibiting a familial pattern of incidence, which have been attributable to mutations in high penetrance susceptibility genes, such as BRCA1 and BRCA2. However, these mutations only account to approximately 25% of the families with inherited breast cancer; therefore, id...