8 documents found, page 1 of 1
miRNA-21 regulates CD69 and IL-10 expression in canine leishmaniasis
Bragato, Jaqueline Poleto [UNESP]; Rebech, Gabriela Torres [UNESP]; de Freitas, Jéssica Henrique [UNESP]; dos Santos, Marilene Oliveira [UNESP]Made available in DSpace on 2022-04-28T19:52:39Z (GMT). No. of bitstreams: 0 Previous issue date: 2022-03-01; Visceral leishmaniasis in humans is a chronic and fatal disease if left untreated. Canine leishmaniasis (CanL) is a severe public health problem because infected animals are powerful transmitters of the parasite to humans via phlebotomine vectors. Therefore, dogs are an essential target for control meas...
Blocking IL-10 signaling with soluble IL-10 receptor restores in vitro specific...
Santos, Catiule de Oliveira; Costa, Sidnei Ferro [UNESP]; Souza, Fabiana Santana; Mendes, Jessica Mariane FerreiraMade available in DSpace on 2021-06-25T11:10:54Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-01-01; rIL-10 plays a major role in restricting exaggerated inflammatory and immune responses, thus preventing tissue damage. However, the restriction of inflammatory and immune responses by IL-10 can also favor the development and/or persistence of chronic infections or neoplasms. Dogs that succumb to canine ...
Development of plasmonic ELISA for the detection of anti-Leishmania sp. IgG ant...
Santos Maciel, Marilene Oliveira dos [UNESP]; Soares, Matheus Fujimura [UNESP]; Costa, Sidnei Ferro [UNESP]; Bragato, Jaqueline Poleto [UNESP]Made available in DSpace on 2020-12-10T19:39:54Z (GMT). No. of bitstreams: 0 Previous issue date: 2019-11-01; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES); Recently, a novel Enzyme-Linked Immunosorbent Assay (ELISA) strategy has emerged, known as plasmonic E...
Plasmonic rK28 ELISA improves the diagnosis of canine Leishmania infection
Oliveira dos Santos Maciel, Marilene [UNESP]; Soares, Matheus Fujimura [UNESP]; Costa, Sidnei Ferro [UNESP]; Bragato, Jaqueline Poleto [UNESP]Made available in DSpace on 2020-12-12T02:30:34Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-02-01; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES); Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); In this study, we evaluated the performance of a new enzyme-linked immunosorbent assay (ELISA) variant known as indirect “plasmonic ELISA” (pELISA) for the detection...
Induction of miR 21 impairs the anti-Leishmania response through inhibition of ...
Melo, Larissa Martins [UNESP]; Bragato, Jaqueline Poleto [UNESP]; Venturin, Gabriela Lovizutto [UNESP]; Rebech, Gabriela Torres [UNESP]Made available in DSpace on 2020-12-12T02:31:19Z (GMT). No. of bitstreams: 0 Previous issue date: 2019-12-01; Visceral Leishmaniasis is a chronic zoonosis and, if left untreated, can be fatal. Infected dogs have decreased cellular immunity (Th1) and develop a potent humoral response (Th2), which is not effective for elimination of the protozoan. Immune response can be modulated by microRNAs (miRNAs), however, c...
Regulatory effect of PGE2 on microbicidal activity and inflammatory cytokines i...
Venturin, Gabriela Lovizutto [UNESP]; Bragato, Jaqueline Poleto [UNESP]; Melo, Larissa Martins [UNESP]; Rebech, Gabriela Torres [UNESP]Made available in DSpace on 2020-12-12T02:38:44Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-06-01; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES); Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); Canine leishmaniasis (CanL) is caused by the intracellular parasite Leishmania infantum. Prostaglandin...
PD-1 regulates leishmanicidal activity and IL-17 in dogs with leishmaniasis
Rebech, Gabriela Torres [UNESP]; Venturin, Gabriela Lovizutto [UNESP]; Siqueira Ito, Lucas Takeshi [UNESP]; Bragato, Jaqueline Poleto [UNESP]Made available in DSpace on 2020-12-12T00:59:20Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-01-01; Leishmaniasis is an immunosuppressive disease caused by protozoa of the genus Leishmania, for which dogs are the domestic reservoir. The programmed cell death-1 molecule (PD-1) is highly expressed in leukocyte cells of dogs with leishmaniasis, and it promotes T lymphocyte exhaustion and suppression of c...
Combined in vitro il-12 and il-15 stimulation promotes cellular immune response...
Costa, Sidnei Ferro [UNESP]; Gomes, Vinícius Oliveira [UNESP]; Maciel, Marilene Oliveira Dos Santos [UNESP]; Melo, Larissa Martins [UNESP]Made available in DSpace on 2020-12-12T01:14:35Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-01-01; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES); Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); Domestic dogs are the main reservoir of Leishmania infantum, a causative agent of visceral leishmanias...